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Science 20 November 1998:
Vol. 282. no. 5393, pp. 1504 - 1508
DOI: 10.1126/science.282.5393.1504
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Reports

Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Takao K. Hensch, * Michela Fagiolini, Nobuko Mataga, Michael P. Stryker, Steinunn Baekkeskov, Shera F. Kash

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.

T. K. Hensch, M. Fagiolini, N. Mataga, Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. M. P. Stryker, Department of Physiology, University of California, San Francisco, CA 94143, USA. S. Baekkeskov and S. F. Kash, Department of Medicine and Microbiology/Immunology, Hormone Research Institute, University of California, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed. E-mail: hensch{at}postman.riken.go.jp

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   Abstract »    Full Text »    PDF »
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