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Science 20 November 1998:
Vol. 282. no. 5393, pp. 1432 - 1436
DOI: 10.1126/science.282.5393.1432
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Review
Experimental Evolution of Parasites
Dieter Ebert
Serial passage experiments are a form of experimental evolution
that is frequently used in applied sciences; for example, in vaccine
development. During these experiments, molecular and phenotypic
evolution can be monitored in real time, providing insights into the
causes and consequences of parasite evolution. Within-host competition
generally drives an increase in a parasite's virulence in a new host,
whereas the parasite becomes avirulent to its former host, indicating a
trade-off between parasite fitnesses on different hosts. Understanding
why parasite virulence seldom escalates similarly in natural
populations could help us to manage virulence and deal with emerging
diseases.
The author is at the Universität Basel, Zoologisches
Institut, Rheinsprung 9, 4051 Basel, Switzerland. E-mail:
ebert{at}ubaclu.unibas.ch
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