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Science 13 November 1998:
Vol. 282. no. 5392, pp. 1338 - 1341
DOI: 10.1126/science.282.5392.1338
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Reports

Control of Neonatal Tolerance to Tissue Antigens by Peripheral T Cell Trafficking

Judith Alferink, Anna Tafuri, * Dietmar Vestweber, Rupert Hallmann, Günter J. Hämmerling, Bernd Arnold dagger

Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naïve CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin-expressed antigens.

J. Alferink, A. Tafuri, G. J. Hämmerling, B. Arnold, Tumor Immunology Program, German Cancer Research Center, 69120 Heidelberg, Germany. D. Vestweber, Institute of Cell Biology, University of Münster, 48149 Münster, Germany. R. Hallmann, Institute for Experimental Medicine, University of Erlangen-Nürnberg, 91054 Erlangen, Germany.
*   Present address: Ontario Cancer Institute/Amgen Institute, Toronto, Ontario M5G 2C1, Canada.

dagger    To whom correspondence should be addressed.

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