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Science 6 November 1998:
Vol. 282. no. 5391, pp. 1126 - 1132
DOI: 10.1126/science.282.5391.1126
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Reports

Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum

Malcolm J. Gardner, Hervé Tettelin, Daniel J. Carucci, Leda M. Cummings, L. Aravind, Eugene V. Koonin, Shamira Shallom, Tanya Mason, Kelly Yu, Claire Fujii, James Pederson, Kun Shen, Junping Jing, Christopher Aston, Zhongwu Lai, David C. Schwartz, Mihaela Pertea, Steven Salzberg, Lixin Zhou, * Granger G. Sutton, dagger Rebecca Clayton, Owen White, Hamilton O. Smith, dagger Claire M. Fraser, Mark D. Adams, dagger J. Craig Venter, dagger Stephen L. Hoffman ddagger

Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

M. J. Gardner, H. Tettelin, L. M. Cummings, S. Shallom, T. Mason, K. Yu, C. Fujii, J. Pederson, K. Shen, L. Zhou, G. G. Sutton, R. Clayton, O. White, H. O. Smith, C. M. Fraser, M. D. Adams, J. C. Venter, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. D. J. Carucci and S. L. Hoffman, Malaria Program, Naval Medical Research Institute, 12300 Washington Avenue, Rockville, MD 20852, USA. L. Aravind, Department of Biology, Texas A & M University, College Station, TX 70843, USA, and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. E. V. Koonin, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. J. Jing, C. Aston, Z. Lai, D. C. Schwartz, W. M. Keck Laboratory for Biomolecular Imaging, Department of Chemistry, New York University, New York, NY 10003, USA. M. Pertea, Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA. S. Salzberg, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA, and Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA.
*   Present address: ARIAD Pharmaceuticals, 26 Landsdowne Street, Cambridge, MA 02139, USA.

dagger    Present address: Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.

ddagger    To whom correspondence should be addressed. E-mail: hoffmans{at}nmripo.nmri.nnmc.navy.mil

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