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Science 23 October 1998:
Vol. 282. no. 5389, pp. 682 - 689
DOI: 10.1126/science.282.5389.682
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Review

New Goals for the U.S. Human Genome Project: 1998-2003

Francis S. Collins, * Ari Patrinos, Elke Jordan, Aravinda Chakravarti, Raymond Gesteland, LeRoy Walters, the members of the DOE and NIH planning groups

The Human Genome Project has successfully completed all the major goals in its current 5-year plan, covering the period 1993-98. A new plan, for 1998-2003, is presented, in which human DNA sequencing will be the major emphasis. An ambitious schedule has been set to complete the full sequence by the end of 2003, 2 years ahead of previous projections. In the course of completing the sequence, a "working draft" of the human sequence will be produced by the end of 2001. The plan also includes goals for sequencing technology development; for studying human genome sequence variation; for developing technology for functional genomics; for completing the sequence of Caenorhabditis elegans and Drosophila melanogaster and starting the mouse genome; for studying the ethical, legal, and social implications of genome research; for bioinformatics and computational studies; and for training of genome scientists.

F. S. Collins and E. Jordan are with the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. A. Patrinos is with the Office of Biological and Environmental Research, Department of Energy, Washington, DC 20585, USA. A. Chakravarti is with the Department of Genetics and Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA. R. Gesteland is at the Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA. L. Walters is with the Kennedy Institute of Ethics, Georgetown University, Washington, DC 20057, USA.
*   To whom correspondence should be addressed: E-mail: fc23a{at}nih.gov

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