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Science 9 October 1998:
Vol. 282. no. 5387, pp. 290 - 293
DOI: 10.1126/science.282.5387.290
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Reports

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

Martin Bennett, * Kirsty Macdonald, Shiu-Wan Chan, J. Paul Luzio, Robert Simari, Peter Weissberg

p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.

M. Bennett, K. Macdonald, S.-W. Chan, P. Weissberg, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. J. P. Luzio, Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. R. Simari, Department of Cardiovascular Diseases, Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
*   To whom correspondence should be addressed. E-mail: mrb{at}mole.bio.cam.ac.uk

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J.-H. Li, M. Chia, W. Shi, D. Ngo, C. A. Strathdee, D. Huang, H. Klamut, and F.-F. Liu (2002)
Cancer Res. 62, 171-178
   Abstract »    Full Text »    PDF »
Acute and Chronic Smooth Muscle Cell Apoptosis After Mechanical Vascular Injury Can Occur Independently of the Fas-Death Pathway.
M. Sata, S. Sugiura, M. Yoshizumi, Y. Ouchi, Y. Hirata, and R. Nagai (2001)
Arterioscler Thromb Vasc Biol 21, 1733-1737
   Abstract »    Full Text »    PDF »
Cellular stress response and apoptosis in cancer therapy.
I. Herr and K.-M. Debatin (2001)
Blood 98, 2603-2614
   Abstract »    Full Text »    PDF »
Par-4 Drives Trafficking and Activation of Fas and FasL to Induce Prostate Cancer Cell Apoptosis and Tumor Regression.
M. Chakraborty, S. G. Qiu, K. M. Vasudevan, and V. M. Rangnekar (2001)
Cancer Res. 61, 7255-7263
   Abstract »    Full Text »    PDF »
Human Blood-Derived Macrophages Induce Apoptosis in Human Plaque-Derived Vascular Smooth Muscle Cells by Fas-Ligand/Fas Interactions.
J. J. Boyle, D. E. Bowyer, P. L. Weissberg, and M. R. Bennett (2001)
Arterioscler Thromb Vasc Biol 21, 1402-1407
   Abstract »    Full Text »    PDF »
Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation.
S. Gilbert, A. Loranger, N. Daigle, and N. Marceau (2001)
J. Cell Biol. 154, 763-774
   Abstract »    Full Text »    PDF »
Measures of Cell Turnover (Proliferation and Apoptosis) and Their Association with Survival in Breast Cancer.
S. Liu, S. M. Edgerton, D. H. Moore II, and A. D. Thor (2001)
Clin. Cancer Res. 7, 1716-1723
   Abstract »    Full Text »    PDF »
Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated.
C.-S. Chung, W. Wang, I. H. Chaudry, and A. Ayala (2001)
Am J Physiol Gastrointest Liver Physiol 280, G812-G818
   Abstract »    Full Text »    PDF »
Upregulation of Glucose Metabolism During Intimal Lesion Formation Is Coupled to the Inhibition of Vascular Smooth Muscle Cell Apoptosis: Role of GSK3{beta}.
J. L. Hall, J. C. Chatham, H. Eldar-Finkelman, and G. H. Gibbons (2001)
Diabetes 50, 1171-1179
   Abstract »    Full Text »
Direct Stimulation of Apoptotic Signaling by Soluble Apo2L/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Leads to Selective Killing of Glioma Cells.
I. F. Pollack, M. Erff, and A. Ashkenazi (2001)
Clin. Cancer Res. 7, 1362-1369
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Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells.
M. T. Tian, C.-H. G. Chou, and A. L. DeFranco (2001)
Int. Immunol. 13, 581-592
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Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor {gamma}-chain signaling and inhibited by cyclosporin A.
E. Chklovskaia, C. Nissen, L. Landmann, C. Rahner, O. Pfister, and A. Wodnar-Filipowicz (2001)
Blood 97, 1027-1034
   Abstract »    Full Text »    PDF »
Apoptosis of Bovine Granulosa Cells After Serum Withdrawal Is Mediated by Fas Antigen (CD95) and Fas Ligand.
C.-L. Hu, R. G. Cowan, R. M. Harman, D. A. Porter, and S. M. Quirk (2001)
Biol Reprod 64, 518-526
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New insights into atherosclerotic plaque rupture.
D M Braganza and M R Bennett (2001)
Postgrad. Med. J. 77, 94-98
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Caspase Activation by Adenovirus E4orf4 Protein Is Cell Line Specific and Is Mediated by the Death Receptor Pathway.
A. Livne, R. Shtrichman, and T. Kleinberger (2001)
J. Virol. 75, 789-798
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FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis.
H. Ungefroren, M.-L. Kruse, A. Trauzold, S. Roeschmann, C. Roeder, A. Arlt, D. Henne-Bruns, and H. Kalthoff (2001)
J. Cell Sci. 114, 2735-2746
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