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Science 9 October 1998:
Vol. 282. no. 5387, pp. 287 - 290
DOI: 10.1126/science.282.5387.287
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Reports

Role of Farnesyltransferase in ABA Regulation of Guard Cell Anion Channels and Plant Water Loss

Zhen-Ming Pei, Majid Ghassemian, Christine M. Kwak, Peter McCourt, Julian I. Schroeder *

Desiccation of plants during drought can be detrimental to agricultural production. The phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in leaves, a process requiring ion-channel modulation by cytoplasmic proteins. Deletion of the Arabidopsis farnesyltransferase gene ERA1 or application of farnesyltransferase inhibitors resulted in ABA hypersensitivity of guard cell anion-channel activation and of stomatal closing. ERA1 was expressed in guard cells. Double-mutant analyses of era1 with the ABA-insensitive mutants abi1 and abi2 showed that era1 suppresses the ABA-insensitive phenotypes. Moreover, era1 plants exhibited a reduction in transpirational water loss during drought treatment.

Z.-M. Pei, C. M. Kwak, J. I. Schroeder, Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093-0116, USA. M. Ghassemian and P. McCourt, Department of Botany, University of Toronto, 25 Willcocks Street, Toronto M5S 3B2, Canada.
*   To whom correspondence should be addressed at Department of Biology, University of California, San Diego, La Jolla, CA 92093-0116, USA. E-mail: julian{at}biomail.ucsd.edu

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