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Science 25 September 1998:
Vol. 281. no. 5385, pp. 2038 - 2042
DOI: 10.1126/science.281.5385.2038
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Reports

Impaired Spatial Learning after Saturation of Long-Term Potentiation

Edvard I. Moser, * Kurt A. Krobert, May-Britt Moser, Richard G. M. Morris

If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.

E. I. Moser and M.-B. Moser, Department of Psychology, Norwegian University of Science and Technology, 7034 Trondheim, Norway. K. A. Krobert, Cardiovascular Research Centre, Institute for Surgical Research, University of Oslo, Rikshospitalet, N-0027 Oslo, Norway. R. G. M. Morris, Centre for Neuroscience, University of Edinburgh, Crichton Street, Edinburgh EH8 9LE, UK.
*   To whom correspondence should be addressed. E-mail: edvard.moser{at}sv.ntnu.no

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