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Science 18 September 1998:
Vol. 281. no. 5384, pp. 1860 - 1863
DOI: 10.1126/science.281.5384.1860
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Reports

Activation of Apoptosis Signal- Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx

Howard Y. Chang, * Hideki Nishitoh, * Xiaolu Yang, dagger Hidenori Ichijo, ddagger David Baltimore ddagger

The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.

H. Y. Chang and X. Yang, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA. H. Nishitoh and H. Ichijo, Department of Biomaterials Science, Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, and Department of Biochemistry, Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan. D. Baltimore, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, and California Institute of Technology, Pasadena, CA 91125, USA.
*   These authors contributed equally to this work.

dagger    Present address: Department of Molecular and Cellular Engineering and Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104, USA.

ddagger    To whom correspondence should be addressed.

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Hum. Mol. Genet. 11, 2895-2904
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Cutting Edge: Tyk2 Is Required for the Induction and Nuclear Translocation of Daxx Which Regulates IFN-{alpha}-Induced Suppression of B Lymphocyte Formation.
K. Shimoda, K. Kamesaki, A. Numata, K. Aoki, T. Matsuda, K. Oritani, S. Tamiya, K. Kato, K. Takase, R. Imamura, et al. (2002)
J. Immunol. 169, 4707-4711
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Activation of the p38 Signaling Pathway by Heat Shock Involves the Dissociation of Glutathione S-Transferase Mu from Ask1.
S. Dorion, H. Lambert, and J. Landry (2002)
J. Biol. Chem. 277, 30792-30797
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Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
A. D. Hollenbach, C. J. McPherson, E. J. Mientjes, R. Iyengar, and G. Grosveld (2002)
J. Cell Sci. 115, 3319-3330
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Essential Role of the 58-kDa Microspherule Protein in the Modulation of Daxx-dependent Transcriptional Repression as Revealed by Nucleolar Sequestration.
D.-Y. Lin and H.-M. Shih (2002)
J. Biol. Chem. 277, 25446-25456
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Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding.
H. Mita, J. Tsutsui, M. Takekawa, E. A. Witten, and H. Saito (2002)
Mol. Cell. Biol. 22, 4544-4555
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Thioredoxin Promotes ASK1 Ubiquitination and Degradation to Inhibit ASK1-Mediated Apoptosis in a Redox Activity-Independent Manner.
Y. Liu and W. Min (2002)
Circ. Res. 90, 1259-1266
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Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms.
M. Morgan, J. Thorburn, P. P. Pandolfi, and A. Thorburn (2002)
J. Cell Biol. 157, 975-984
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The Insulin-sensitive Glucose Transporter, GLUT4, Interacts Physically with Daxx. TWO PROTEINS WITH CAPACITY TO BIND Ubc9 AND CONJUGATED TO SUMO1.
V. S. Lalioti, S. Vergarajauregui, D. Pulido, and I. V. Sandoval (2002)
J. Biol. Chem. 277, 19783-19791
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Functional Interaction between the pp71 Protein of Human Cytomegalovirus and the PML-Interacting Protein Human Daxx.
H. Hofmann, H. Sindre, and T. Stamminger (2002)
J. Virol. 76, 5769-5783
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Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.
X.-D. Li, T. P. Makela, D. Guo, R. Soliymani, V. Koistinen, O. Vapalahti, A. Vaheri, and H. Lankinen (2002)
J. Gen. Virol. 83, 759-766
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The Interaction of Pax5 (BSAP) with Daxx Can Result in Transcriptional Activation in B Cells.
A. V. Emelyanov, C. R. Kovac, M. A. Sepulveda, and B. K. Birshtein (2002)
J. Biol. Chem. 277, 11156-11164
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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induces Caspase-Dependent Interleukin-8 Expression and Apoptosis in Human Astroglioma Cells.
C. Choi, O. Kutsch, J. Park, T. Zhou, D.-W. Seol, and E. N. Benveniste (2002)
Mol. Cell. Biol. 22, 724-736
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Raf Kinase Inhibitor Protein Interacts with NF-{kappa}B-Inducing Kinase and TAK1 and Inhibits NF-{kappa}B Activation.
K. C. Yeung, D. W. Rose, A. S. Dhillon, D. Yaros, M. Gustafsson, D. Chatterjee, B. McFerran, J. Wyche, W. Kolch, and J. M. Sedivy (2001)
Mol. Cell. Biol. 21, 7207-7217
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Apoptosis Signal-regulating Kinase 1 Controls the Proapoptotic Function of Death-associated Protein (Daxx) in the Cytoplasm.
Y.-G. Ko, Y.-S. Kang, H. Park, W. Seol, J. Kim, T. Kim, H.-S. Park, E.-J. Choi, and S. Kim (2001)
J. Biol. Chem. 276, 39103-39106
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The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1.
X. Zou, T. Tsutsui, D. Ray, J. F. Blomquist, H. Ichijo, D. S. Ucker, and H. Kiyokawa (2001)
Mol. Cell. Biol. 21, 4818-4828
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FGF Induces a Switch in Death Receptor Pathways in Neuronal Cells.
E. M. Eves, C. Skoczylas, K. Yoshida, E. S. Alnemri, and M. R. Rosner (2001)
J. Neurosci. 21, 4996-5006
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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.
J. Chen, K. Fujii, L. Zhang, T. Roberts, and H. Fu (2001)
PNAS
   Abstract »    Full Text »    PDF »
Fas-induced Expression of Chemokines in Human Glioma Cells: Involvement of Extracellular Signal-regulated Kinase 1/2 and p38 Mitogen-activated Protein Kinase.
C. Choi, X. Xu, J.-W. Oh, S. J. Lee, G. Y. Gillespie, H. Park, H. Jo, and E. N. Benveniste (2001)
Cancer Res. 61, 3084-3091
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Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation.
J. M. Kyriakis and J. Avruch (2001)
Physiol Rev 81, 807-869
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Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1.
A. H. Kim, G. Khursigara, X. Sun, T. F. Franke, and M. V. Chao (2001)
Mol. Cell. Biol. 21, 893-901
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Proteases for Cell Suicide: Functions and Regulation of Caspases.
H. Y. Chang and X. Yang (2000)
Microbiol. Mol. Biol. Rev. 64, 821-846
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Apoptosis Induced by Rac GTPase Correlates with Induction of FasL and Ceramides Production.
N. Embade, P. F. Valerón, S. Aznar, E. López-Collazo, and J. C. Lacal (2000)
Mol. Biol. Cell 11, 4347-4358
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