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Science 11 September 1998:
Vol. 281. no. 5383, pp. 1683 - 1686
DOI: 10.1126/science.281.5383.1683
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Reports

Biological Action of Leptin as an Angiogenic Factor

M. Rocío Sierra-Honigmann, * Anjali K. Nath, Chiaki Murakami, Guillermo García-Cardeña, dagger Andreas Papapetropoulos, William C. Sessa, Lisa A. Madge, Jeffrey S. Schechner, Michael B. Schwabb, Peter J. Polverini, Jaime R. Flores-Riveros ddagger

Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells. In vitro and in vivo assays revealed that leptin has angiogenic activity. In vivo, leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which lack functional leptin receptors. These observations indicate that the vascular endothelium is a target for leptin and suggest a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.

M. R. Sierra-Honigmann, A. K. Nath, C. Murakami, G. García-Cardeña, A. Papapetropoulos, W. C. Sessa, L. A. Madge, J. S. Schechner, M. B. Schwabb, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA. P. J. Polverini, Department of Oral Medicine/Pathology/Surgery, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA. J. R. Flores-Riveros, Institute for Metabolic Disorders, Bayer Corporation, West Haven, CT 06516, USA.
*   To whom correspondence should be addressed. E-mail: rocio_sierra-honigmann{at}qm.yale.edu

dagger    Present address: Harvard Medical School, Vascular Research Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

ddagger    Present address: Institute for Diagnostic Research, Branford, CT 06405, USA.

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J. Clin. Endocrinol. Metab. 89, 2563-2568
   Abstract »    Full Text »    PDF »
Leptin Induces, via ERK1/ERK2 Signal, Functional Activation of Estrogen Receptor {alpha} in MCF-7 Cells.
S. Catalano, L. Mauro, S. Marsico, C. Giordano, P. Rizza, V. Rago, D. Montanaro, M. Maggiolini, M. L. Panno, and S. Ando (2004)
J. Biol. Chem. 279, 19908-19915
   Abstract »    Full Text »    PDF »
Adipose tissue angiogenesis.
G. J. Hausman and R. L. Richardson (2004)
J Anim Sci 82, 925-934
   Abstract »    Full Text »    PDF »
Leptin Corrects Increased Gene Expression of Renal 25-Hydroxyvitamin D3-1{alpha}-Hydroxylase and -24-Hydroxylase in Leptin-Deficient, ob/ob Mice.
A. Matsunuma, T. Kawane, T. Maeda, S. Hamada, and N. Horiuchi (2004)
Endocrinology 145, 1367-1375
   Abstract »    Full Text »    PDF »
Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice.
S. C. Chua Jr., S. M. Liu, Q. Li, A. Sun, W. F. DeNino, S. B. Heymsfield, and X. E. Guo (2004)
Am J Physiol Endocrinol Metab 286, E384-E392
   Abstract »    Full Text »
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.
E. Brakenhielm, N. Veitonmaki, R. Cao, S. Kihara, Y. Matsuzawa, B. Zhivotovsky, T. Funahashi, and Y. Cao (2004)
PNAS 101, 2476-2481
   Abstract »    Full Text »    PDF »
Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives.
V. Planat-Benard, J.-S. Silvestre, B. Cousin, M. Andre, M. Nibbelink, R. Tamarat, M. Clergue, C. Manneville, C. Saillan-Barreau, M. Duriez, et al. (2004)
Circulation 109, 656-663
   Abstract »    Full Text »    PDF »
Pathologic Variables and Recurrence Rates As Related to Obesity and Race in Men With Prostate Cancer Undergoing Radical Prostatectomy.
C. L. Amling, R. H. Riffenburgh, L. Sun, J. W. Moul, R. S. Lance, L. Kusuda, W. J. Sexton, D. W. Soderdahl, T. F. Donahue, J. P. Foley, et al. (2004)
J. Clin. Oncol. 22, 439-445
   Abstract »    Full Text »    PDF »
Isomers of Conjugated Linoleic Acid Differ in Their Effects on Angiogenesis and Survival of Mouse Mammary Adipose Vasculature.
P. A. Masso-Welch, D. Zangani, C. Ip, M. M. Vaughan, S. F. Shoemaker, S. O. McGee, and M. M. Ip (2004)
J. Nutr. 134, 299-307
   Abstract »    Full Text »    PDF »
Leptin Effects on Pancreatic {beta}-Cell Gene Expression and Function.
J. Seufert (2004)
Diabetes 53, S152-158
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From Fat Fighter to Risk Factor: The Zigzag Trek of Leptin.
N. Werner and G. Nickenig (2004)
Arterioscler Thromb Vasc Biol 24, 7-9
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Leptin Reverses the Inhibitory Effect of Caloric Restriction on Longitudinal Growth.
G. Gat-Yablonski, T. Ben-Ari, B. Shtaif, O. Potievsky, O. Moran, R. Eshet, G. Maor, Y. Segev, and M. Phillip (2004)
Endocrinology 145, 343-350
   Abstract »    Full Text »    PDF »
Leptin Promotes Vascular Remodeling and Neointimal Growth in Mice.
K. Schafer, M. Halle, C. Goeschen, C. Dellas, M. Pynn, D. J. Loskutoff, and S. Konstantinides (2004)
Arterioscler Thromb Vasc Biol 24, 112-117
   Abstract »    Full Text »    PDF »


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