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Science 4 September 1998:
Vol. 281. no. 5382, pp. 1509 - 1512
DOI: 10.1126/science.281.5382.1509
Prev | Table of Contents | Next

Reports

Identification of c-MYC as a Target of the APC Pathway

Tong-Chuan He, Andrew B. Sparks, Carlo Rago, Heiko Hermeking, Leigh Zawel, Luis T. da Costa, Patrice J. Morin, Bert Vogelstein, Kenneth W. Kinzler *

The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of beta -catenin, which then binds T cell factor-4 (Tcf-4), causing increased transcriptional activation of unknown genes. Here, the c-MYC oncogene is identified as a target gene in this signaling pathway. Expression of c-MYC was shown to be repressed by wild-type APC and activated by beta -catenin, and these effects were mediated through Tcf-4 binding sites in the c-MYC promoter. These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers.

T.-C. He, C. Rago, B. Vogelstein, Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA. A. B. Sparks, H. Hermeking, L. Zawel, K. W. Kinzler, Johns Hopkins Oncology Center, Baltimore, MD 21231, USA. L. T. da Costa, Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. P. J. Morin, National Institute on Aging, Baltimore, MD 21224, USA.
*   To whom correspondence should be addressed. E-mail: kinzlke{at}welchlink.welch.jhu.edu

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J. Biol. Chem. 283, 809-815
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Downregulation of Dkk3 activates {beta}-catenin/TCF-4 signaling in lung cancer.
W. Yue, Q. Sun, S. Dacic, R. J. Landreneau, J. M. Siegfried, J. Yu, and L. Zhang (2008)
Carcinogenesis 29, 84-92
   Abstract »    Full Text »    PDF »
Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective.
J. M. de Bont, R. J. Packer, E. M. Michiels, M. L. d. Boer, and R. Pieters (2008)
Neuro-oncol 10, 1040-1060
   Abstract »    Full Text »    PDF »
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch.
S. Rao, I. B. Lobov, J. E. Vallance, K. Tsujikawa, I. Shiojima, S. Akunuru, K. Walsh, L. E. Benjamin, and R. A. Lang (2007)
Development 134, 4449-4458
   Abstract »    Full Text »    PDF »
A Unique DNA Binding Domain Converts T-Cell Factors into Strong Wnt Effectors.
F. A. Atcha, A. Syed, B. Wu, N. P. Hoverter, N. N. Yokoyama, J.-H. T. Ting, J. E. Munguia, H. J. Mangalam, J. L. Marsh, and M. L. Waterman (2007)
Mol. Cell. Biol. 27, 8352-8363
   Abstract »    Full Text »    PDF »
Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc Expression.
K. Yekkala and T. A. Baudino (2007)
Mol. Cancer Res. 5, 1296-1303
   Abstract »    Full Text »    PDF »
Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of beta-Catenin.
G.-Y. Song, J.-H. Lee, M. Cho, B.-S. Park, D.-E. Kim, and S. Oh (2007)
Mol. Pharmacol. 72, 1599-1606
   Abstract »    Full Text »    PDF »
Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence.
F. A. Mallette, M.-F. Gaumont-Leclerc, G. Huot, and G. Ferbeyre (2007)
J. Biol. Chem. 282, 34938-34944
   Abstract »    Full Text »    PDF »
{alpha}-Catenin is essential in intestinal adenoma formation.
H. Shibata, H. Takano, M. Ito, H. Shioya, M. Hirota, H. Matsumoto, Y. Kakudo, C. Ishioka, T. Akiyama, Y. Kanegae, et al. (2007)
PNAS 104, 18199-18204
   Abstract »    Full Text »    PDF »
{beta}-Catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone.
K. Adachi, Z. Mirzadeh, M. Sakaguchi, T. Yamashita, T. Nikolcheva, Y. Gotoh, G. Peltz, L. Gong, T. Kawase, A. Alvarez-Buylla, et al. (2007)
Stem Cells 25, 2827-2836
   Abstract »    Full Text »    PDF »
WNT10B Functional Dualism: beta-Catenin/Tcf-dependent Growth Promotion or Independent Suppression with Deregulated Expression in Cancer.
H. Yoshikawa, K. Matsubara, X. Zhou, S. Okamura, T. Kubo, Y. Murase, Y. Shikauchi, M. Esteller, J. G. Herman, X. Wei Wang, et al. (2007)
Mol. Biol. Cell 18, 4292-4303
   Abstract »    Full Text »    PDF »
{beta}-Catenin Regulates Multiple Steps of RNA Metabolism as Revealed by the RNA Aptamer in Colon Cancer Cells.
H. K. Lee, H. Y. Kwak, J. Hur, I. A. Kim, J. S. Yang, M. W. Park, J. Yu, and S. Jeong (2007)
Cancer Res. 67, 9315-9321
   Abstract »    Full Text »    PDF »
Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.
K. Aoki and M. M. Taketo (2007)
J. Cell Sci. 120, 3327-3335
   Abstract »    Full Text »    PDF »
Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and {beta}-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
T. Imai, K. Fukuta, M. Hasumura, Y.-M. Cho, Y. Ota, S. Takami, H. Nakagama, and M. Hirose (2007)
Carcinogenesis 28, 2199-2206
   Abstract »    Full Text »    PDF »
Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting beta-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription.
M. Almeida, L. Han, M. Martin-Millan, C. A. O'Brien, and S. C. Manolagas (2007)
J. Biol. Chem. 282, 27298-27305
   Abstract »    Full Text »    PDF »
Salmonella Effector AvrA Regulation of Colonic Epithelial Cell Inflammation by Deubiquitination.
Z. Ye, E. O. Petrof, D. Boone, E. C. Claud, and J. Sun (2007)
Am. J. Pathol. 171, 882-892
   Abstract »    Full Text »    PDF »
Involvement of RNA Helicases p68 and p72 in Colon Cancer.
S. Shin, K. L. Rossow, J. P. Grande, and R. Janknecht (2007)
Cancer Res. 67, 7572-7578
   Abstract »    Full Text »    PDF »


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