Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 August 1998:
Vol. 281. no. 5381, pp. 1322 - 1326
DOI: 10.1126/science.281.5381.1322
Prev | Table of Contents | Next

Review

The Bcl-2 Protein Family: Arbiters of Cell Survival

Jerry M. Adams, Suzanne Cory

REVIEW

Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens. Those most similar to Bcl-2 promote cell survival by inhibiting adapters needed for activation of the proteases (caspases) that dismantle the cell. More distant relatives instead promote apoptosis, apparently through mechanisms that include displacing the adapters from the pro-survival proteins. Thus, for many but not all apoptotic signals, the balance between these competing activities determines cell fate. Bcl-2 family members are essential for maintenance of major organ systems, and mutations affecting them are implicated in cancer.

The authors are at the Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Novel Function of CRTH2 in Preventing Apoptosis of Human Th2 Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway.
L. Xue, A. Barrow, and R. Pettipher (2009)
J. Immunol. 182, 7580-7586
   Abstract »    Full Text »    PDF »
Thiacremonone Augments Chemotherapeutic Agent-Induced Growth Inhibition in Human Colon Cancer Cells through Inactivation of Nuclear Factor-{kappa}B.
J. O. Ban, H. S. Lee, H.-S. Jeong, S. Song, B. Y. Hwang, D. C. Moon, D. Y. Yoon, S. B. Han, and J. T. Hong (2009)
Mol. Cancer Res. 7, 870-879
   Abstract »    Full Text »    PDF »
Differential Gene Expression in the Testes of Different Murine Strains Under Normal and Hyperthermic Conditions.
Y. Li, Q. Zhou, R. Hively, L. Yang, C. Small, and M. D. Griswold (2009)
J Androl 30, 325-337
   Abstract »    Full Text »    PDF »
Transforming growth factor-{beta}1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.
Q. Lu, B. Patel, E. O. Harrington, and S. Rounds (2009)
Am J Physiol Lung Cell Mol Physiol 296, L825-L838
   Abstract »    Full Text »    PDF »
Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway.
M. Jiang, C.-Y. Wang, S. Huang, T. Yang, and Z. Dong (2009)
Am J Physiol Renal Physiol 296, F983-F993
   Abstract »    Full Text »    PDF »
Beyond Monoclonal Antibodies: New Therapeutic Agents in Non-Hodgkin's Lymphomas.
A. Delmonte, M. Ghielmini, and C. Sessa (2009)
Oncologist 14, 511-525
   Abstract »    Full Text »    PDF »
Cleavage of Bid by Executioner Caspases Mediates Feed Forward Amplification of Mitochondrial Outer Membrane Permeabilization during Genotoxic Stress-induced Apoptosis in Jurkat Cells.
S. N. Shelton, M. E. Shawgo, and J. D. Robertson (2009)
J. Biol. Chem. 284, 11247-11255
   Abstract »    Full Text »    PDF »
Cyclophilin D Interacts with Bcl2 and Exerts an Anti-apoptotic Effect.
R. A. Eliseev, J. Malecki, T. Lester, Y. Zhang, J. Humphrey, and T. E. Gunter (2009)
J. Biol. Chem. 284, 9692-9699
   Abstract »    Full Text »    PDF »
The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim.
A. L. Desbien, J. W. Kappler, and P. Marrack (2009)
PNAS 106, 5663-5668
   Abstract »    Full Text »    PDF »
Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart.
C. D. Garciarena, C. I. Caldiz, E. L. Portiansky, G. E. Chiappe de Cingolani, and I. L. Ennis (2009)
J Appl Physiol 106, 1325-1331
   Abstract »    Full Text »    PDF »
The Membrane Mucin Muc4 Inhibits Apoptosis Induced by Multiple Insults via ErbB2-Dependent and ErbB2-Independent Mechanisms.
H. C. Workman, C. Sweeney, and K. L. Carraway III (2009)
Cancer Res. 69, 2845-2852
   Abstract »    Full Text »    PDF »
Antiangiogenic and Proapoptotic Activities of Allyl Isothiocyanate Inhibit Ascites Tumor Growth in Vivo.
A. Kumar, S. S. D'Souza, S. Tickoo, B. P. Salimath, and H.B. Singh (2009)
Integr Cancer Ther 8, 75-87
   Abstract »    PDF »
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
X. Deng, F. Gao, and W. S. May (2009)
Blood 113, 422-428
   Abstract »    Full Text »    PDF »
Involvement of the Apoptotic Mechanism in Pemphigus Foliaceus Autoimmune Injury of the Skin.
N. Li, M. Zhao, J. Wang, Z. Liu, and L. A. Diaz (2009)
J. Immunol. 182, 711-717
   Abstract »    Full Text »    PDF »
The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFN{gamma}-induced cell death.
Y. A. Mebratu, B. F. Dickey, C. Evans, and Y. Tesfaigzi (2008)
J. Cell Biol. 183, 429-439
   Abstract »    Full Text »    PDF »
Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo.
S. D. Stan, E.-R. Hahm, R. Warin, and S. V. Singh (2008)
Cancer Res. 68, 7661-7669
   Abstract »    Full Text »    PDF »
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection.
J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer, A. Y. Deutch, G. E. Duncan, C. E. Marx, J. R. Aprille, D. S. Dwyer, X.-M. Li, S. P. Mahadik, et al. (2008)
Pharmacol. Rev. 60, 358-403
   Abstract »    Full Text »    PDF »
Oxidative Stress: A Common Factor in Testicular Dysfunction.
T. T. Turner and J. J. Lysiak (2008)
J Androl 29, 488-498
   Abstract »    Full Text »    PDF »
Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress.
C. C. Jiang, K. Lucas, K. A. Avery-Kiejda, M. Wade, C. E. deBock, R. F. Thorne, J. Allen, P. Hersey, and X. D. Zhang (2008)
Cancer Res. 68, 6708-6717
   Abstract »    Full Text »    PDF »
Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation.
K. Padhan, R. Minakshi, M. A. B. Towheed, and S. Jameel (2008)
J. Gen. Virol. 89, 1960-1969
   Abstract »    Full Text »    PDF »
Propofol Protects Hepatic L02 Cells from Hydrogen Peroxide-Induced Apoptosis via Activation of Extracellular Signal-Regulated Kinases Pathway.
H. Wang, Z. Xue, Q. Wang, X. Feng, and Z. Shen (2008)
Anesth. Analg. 107, 534-540
   Abstract »    Full Text »    PDF »
Phosphorylation of Murine Caspase-9 by the Protein Kinase Casein Kinase 2 Regulates Its Cleavage by Caspase-8.
M. A. McDonnell, Md. J. Abedin, M. Melendez, T. N. Platikanova, J. R. Ecklund, K. Ahmed, and A. Kelekar (2008)
J. Biol. Chem. 283, 20149-20158
   Abstract »    Full Text »    PDF »
Mammalian Target of Rapamycin and Caspase Inhibitors in Polycystic Kidney Disease.
C. L. Edelstein (2008)
Clin. J. Am. Soc. Nephrol. 3, 1219-1226
   Abstract »    Full Text »    PDF »
EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer.
B. Kumar, K. G. Cordell, J. S. Lee, F. P. Worden, M. E. Prince, H. H. Tran, G. T. Wolf, S. G. Urba, D. B. Chepeha, T. N. Teknos, et al. (2008)
J. Clin. Oncol. 26, 3128-3137
   Abstract »    Full Text »    PDF »
Transforming growth factor-{beta}1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
Q. Lu (2008)
Am J Physiol Lung Cell Mol Physiol 295, L123-L133
   Abstract »    Full Text »    PDF »
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
D. Zhai, C. Jin, C.-w. Shiau, S. Kitada, A. C. Satterthwait, and J. C. Reed (2008)
Mol. Cancer Ther. 7, 1639-1646
   Abstract »    Full Text »    PDF »
Targeting Apoptosis via Chemical Design.
M. Pellecchia, J. Wei, S. Kitada, M. F Rega, and J. C Reed (2008)
Am. Assoc. Cancer Res. Educ. Book 2008, 269-273
   Abstract »    Full Text »    PDF »
Multimodal Targeting of the BCL-2 Family in Cancer.
L. D Walensky (2008)
Am. Assoc. Cancer Res. Educ. Book 2008, 349-356
   Abstract »    Full Text »    PDF »
Pathways involved in testicular germ cell apoptosis in immature rats after FSH suppression.
S. M Ruwanpura, R. I McLachlan, P. G Stanton, K. L Loveland, and S. J Meachem (2008)
J. Endocrinol. 197, 35-43
   Abstract »    Full Text »    PDF »
Expression of p53 and Bcl-xL as Predictive Markers for Larynx Preservation in Advanced Laryngeal Cancer.
B. Kumar, K. G. Cordell, N. D'Silva, M. E. Prince, M. E. Adams, S. G. Fisher, G. T. Wolf, T. E. Carey, and C. R. Bradford (2008)
Arch Otolaryngol Head Neck Surg 134, 363-369
   Abstract »    Full Text »    PDF »
Thrombopoietin Inhibits Murine Mast Cell Differentiation.
F. Martelli, B. Ghinassi, R. Lorenzini, A. M. Vannucchi, R. A. Rana, M. Nishikawa, S. Partamian, G. Migliaccio, and A. R. Migliaccio (2008)
Stem Cells 26, 912-919
   Abstract »    Full Text »    PDF »
Follicle-Stimulating Hormone Affects Spermatogonial Survival by Regulating the Intrinsic Apoptotic Pathway in Adult Rats.
S. M. Ruwanpura, R. I. McLachlan, P. G. Stanton, and S. J. Meachem (2008)
Biol Reprod 78, 705-713
   Abstract »    Full Text »    PDF »
Chymotrypsin B Cached in Rat Liver Lysosomes and Involved in Apoptotic Regulation through a Mitochondrial Pathway.
Q. Miao, Y. Sun, T. Wei, X. Zhao, K. Zhao, L. Yan, X. Zhang, H. Shu, and F. Yang (2008)
J. Biol. Chem. 283, 8218-8228
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2 Regulates Survival, Migration, and Invasion of Human Endometriotic Cells through Multiple Mechanisms.
S. K. Banu, J. Lee, V. O. Speights Jr., A. Starzinski-Powitz, and J. A. Arosh (2008)
Endocrinology 149, 1180-1189
   Abstract »    Full Text »    PDF »
Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men.
S. M. Ruwanpura, R. I. McLachlan, K. L. Matthiesson, and S. J. Meachem (2008)
Hum. Reprod. 23, 403-411
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2 Deficiency Enhances Th2 Immune Responses and Impairs Neutrophil Recruitment in Hepatic Ischemia/Reperfusion Injury.
T. Hamada, S. Tsuchihashi, A. Avanesyan, S. Duarte, C. Moore, R. W. Busuttil, and A. J. Coito (2008)
J. Immunol. 180, 1843-1853
   Abstract »    Full Text »    PDF »
Oxygen regulation of arterial smooth muscle cell proliferation and survival.
J. B. Ray, S. Arab, Y. Deng, P. Liu, L. Penn, D. W. Courtman, and M. E. Ward (2008)
Am J Physiol Heart Circ Physiol 294, H839-H852
   Abstract »    Full Text »    PDF »
Heart mitochondria: gates of life and death.
A. B. Gustafsson and R. A. Gottlieb (2008)
Cardiovasc Res 77, 334-343
   Abstract »    Full Text »    PDF »
Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment.
S. W.G. Tait, E. de Vries, C. Maas, A. M. Keller, C. S. D'Santos, and J. Borst (2007)
J. Cell Biol. 179, 1453-1466
   Abstract »    Full Text »    PDF »
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
D. J. Patel, A. T. Phan, and V. Kuryavyi (2007)
Nucleic Acids Res. 35, 7429-7455
   Abstract »    Full Text »    PDF »
Sensitive Gene Expression Profiling of Human T Cell Subsets Reveals Parallel Post-Thymic Differentiation for CD4+ and CD8+ Lineages.
V. Appay, A. Bosio, S. Lokan, Y. Wiencek, C. Biervert, D. Kusters, E. Devevre, D. Speiser, P. Romero, N. Rufer, et al. (2007)
J. Immunol. 179, 7406-7414
   Abstract »    Full Text »    PDF »
Caspase-9-induced Mitochondrial Disruption through Cleavage of Anti-apoptotic BCL-2 Family Members.
M. Chen, A. D. Guerrero, L. Huang, Z. Shabier, M. Pan, T.-H. Tan, and J. Wang (2007)
J. Biol. Chem. 282, 33888-33895
   Abstract »    Full Text »    PDF »
Juxtacrine Activation of Epidermal Growth Factor (EGF) Receptor by Membrane-anchored Heparin-binding EGF-like Growth Factor Protects Epithelial Cells from Anoikis While Maintaining an Epithelial Phenotype.
A. B. Singh, K. Sugimoto, and R. C. Harris (2007)
J. Biol. Chem. 282, 32890-32901
   Abstract »    Full Text »    PDF »
Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.
M M Conradie, H de Wet, D D R Kotze, J M Burrin, F S Hough, and P A Hulley (2007)
J. Endocrinol. 195, 229-240
   Abstract »    Full Text »    PDF »
Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection.
R. Aneja, V. Kalia, R. Ahmed, and H. C. Joshi (2007)
Mol. Cancer Ther. 6, 2891-2899
   Abstract »    Full Text »    PDF »
Inhibition of MEK Sensitizes Human Melanoma Cells to Endoplasmic Reticulum Stress-Induced Apoptosis.
C. C. Jiang, L. H. Chen, S. Gillespie, Y. F. Wang, K. A. Kiejda, X. D. Zhang, and P. Hersey (2007)
Cancer Res. 67, 9750-9761
   Abstract »    Full Text »    PDF »
Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells.
A. K. Pathak, M. Bhutani, A. S. Nair, K. S. Ahn, A. Chakraborty, H. Kadara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Mol. Cancer Res. 5, 943-955
   Abstract »    Full Text »    PDF »
Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells.
M. A. Napolitano, M. Cipollaro, A. Cascino, M. A. B. Melone, A. Giordano, and U. Galderisi (2007)
J. Cell Sci. 120, 2904-2911
   Abstract »    Full Text »    PDF »
Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1.
Y. F. Wang, C. C. Jiang, K. A. Kiejda, S. Gillespie, X. D. Zhang, and P. Hersey (2007)
Clin. Cancer Res. 13, 4934-4942
   Abstract »    Full Text »    PDF »
Protein Kinase C{zeta} Abrogates the Proapoptotic Function of Bax through Phosphorylation.
M. Xin, F. Gao, W. S. May, T. Flagg, and X. Deng (2007)
J. Biol. Chem. 282, 21268-21277
   Abstract »    Full Text »    PDF »
Epithelial Cell Proliferation Contributes to Airway Remodeling in Severe Asthma.
L. Cohen, X. E, J. Tarsi, T. Ramkumar, T. K. Horiuchi, R. Cochran, S. DeMartino, K. B. Schechtman, I. Hussain, M. J. Holtzman, et al. (2007)
Am. J. Respir. Crit. Care Med. 176, 138-145
   Abstract »    Full Text »    PDF »
Hypoxia Inhibits Paclitaxel-Induced Apoptosis through Adenosine-Mediated Phosphorylation of Bad in Glioblastoma Cells.
S. Merighi, A. Benini, P. Mirandola, S. Gessi, K. Varani, E. Leung, S. Maclennan, P. G. Baraldi, and P. A. Borea (2007)
Mol. Pharmacol. 72, 162-172
   Abstract »    Full Text »    PDF »
Exposure of Myeloid Dendritic Cells to Exogenous or Endogenous IL-10 during Maturation Determines Their Longevity.
W. L. W. Chang, N. Baumgarth, M. K. Eberhardt, C. Y. D. Lee, C. A. Baron, J. P. Gregg, and P. A. Barry (2007)
J. Immunol. 178, 7794-7804
   Abstract »    Full Text »    PDF »
STAT1 Activation Causes Translocation of Bax to the Endoplasmic Reticulum during the Resolution of Airway Mucous Cell Hyperplasia by IFN-{gamma}.
B. A. Stout, K. Melendez, J. Seagrave, M. J. Holtzman, B. Wilson, J. Xiang, and Y. Tesfaigzi (2007)
J. Immunol. 178, 8107-8116
   Abstract »    Full Text »    PDF »
Expression of Erythropoietin Receptor and In vitro Functional Effects of Epoetins in B-Cell Malignancies.
P. Kokhaei, A. O. Abdalla, L. Hansson, E. Mikaelsson, M. Kubbies, A. Haselbeck, H. Jernberg-Wiklund, H. Mellstedt, and A. Osterborg (2007)
Clin. Cancer Res. 13, 3536-3544
   Abstract »    Full Text »    PDF »
Myeloid Cell Leukemia-1 Inversely Correlates with Glycogen Synthase Kinase-3{beta} Activity and Associates with Poor Prognosis in Human Breast Cancer.
Q. Ding, X. He, W. Xia, J.-M. Hsu, C.-T. Chen, L.-Y. Li, D.-F. Lee, J.-Y. Yang, X. Xie, J.-C. Liu, et al. (2007)
Cancer Res. 67, 4564-4571
   Abstract »    Full Text »    PDF »
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion.
B. Wu, W. Qiu, P. Wang, H. Yu, T. Cheng, G. P Zambetti, L. Zhang, and J. Yu (2007)
Gut 56, 645-654
   Abstract »    Full Text »    PDF »
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma.
F. Luciano, M. Krajewska, P. Ortiz-Rubio, S. Krajewski, D. Zhai, B. Faustin, J.-M. Bruey, B. Bailly-Maitre, A. Lichtenstein, S. K. Kolluri, et al. (2007)
Blood 109, 3849-3855
   Abstract »    Full Text »    PDF »
Protein Kinase C-Dependent Mitochondrial Translocation of Proapoptotic Protein Bax on Activation of Inducible Nitric-Oxide Synthase in Rostral Ventrolateral Medulla Mediates Cardiovascular Depression during Experimental Endotoxemia.
J. Y. H. Chan, A. Y. W. Chang, L.-L. Wang, C.-C. Ou, and S. H. H. Chan (2007)
Mol. Pharmacol. 71, 1129-1139
   Abstract »    Full Text »    PDF »
Mcl-1 Depletion in Apoptosis Elicited by Ionizing Radiation in Peritoneal Resident Macrophages of C3H Mice.
Y. Kubota, K. Kinoshita, K. Suetomi, A. Fujimori, and S. Takahashi (2007)
J. Immunol. 178, 2923-2931
   Abstract »    Full Text »    PDF »
Decompensation of Cardiac Hypertrophy: Cellular Mechanisms and Novel Therapeutic Targets.
A. Diwan and G. W. Dorn II (2007)
Physiology 22, 56-64
   Abstract »    Full Text »    PDF »
Nutlin-3 Protects Kidney Cells during Cisplatin Therapy by Suppressing Bax/Bak Activation.
M. Jiang, N. Pabla, R. F. Murphy, T. Yang, X.-M. Yin, K. Degenhardt, E. White, and Z. Dong (2007)
J. Biol. Chem. 282, 2636-2645
   Abstract »    Full Text »    PDF »
Aspartic protease and caspase 3/7 activation are central for macrophage apoptosis following infection with Escherichia coli.
L. Albee, B. Shi, and H. Perlman (2007)
J. Leukoc. Biol. 81, 229-237
   Abstract »    Full Text »    PDF »
Bcl-2 family members and apoptosis, taken to heart.
A. B. Gustafsson and R. A. Gottlieb (2007)
Am J Physiol Cell Physiol 292, C45-C51
   Abstract »    Full Text »    PDF »
Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells.
C. Brooks, J. Wang, T. Yang, and Z. Dong (2007)
Am J Physiol Renal Physiol 292, F243-F252
   Abstract »    Full Text »    PDF »
Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia.
H. Nuckel, U. H. Frey, M. Bau, L. Sellmann, J. Stanelle, J. Durig, K.-H. Jockel, U. Duhrsen, and W. Siffert (2007)
Blood 109, 290-297
   Abstract »    Full Text »    PDF »
Regulation of Brain Cell Death and Survival After Cardiopulmonary Bypass.
T. Zaitseva, S. Schultz, G. Schears, P. Pastuszko, S. Markowitz, W. Greeley, D. F. Wilson, and A. Pastuszko (2006)
Ann. Thorac. Surg. 82, 2247-2253
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2-derived Prostaglandin E2 Directs Oocyte Maturation by Differentially Influencing Multiple Signaling Pathways.
T. Takahashi, J. D. Morrow, H. Wang, and S. K. Dey (2006)
J. Biol. Chem. 281, 37117-37129
   Abstract »    Full Text »    PDF »
TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein.
G. Hacker, K. Suttner, H. Harada, and S. Kirschnek (2006)
Int. Immunol. 18, 1749-1757
   Abstract »    Full Text »    PDF »
Statin-induced apoptosis and skeletal myopathy.
A. J. Dirks and K. M. Jones (2006)
Am J Physiol Cell Physiol 291, C1208-C1212
   Abstract »    Full Text »    PDF »
Diallyl Trisulfide Suppresses Growth of PC-3 Human Prostate Cancer Xenograft In vivo in Association with Bax and Bak Induction..
D. Xiao, K. L. Lew, Y.-A. Kim, Y. Zeng, E.-R. Hahm, R. Dhir, and S. V. Singh (2006)
Clin. Cancer Res. 12, 6836-6843
   Abstract »    Full Text »    PDF »
Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak..
D. Xiao, V. Vogel, and S. V. Singh (2006)
Mol. Cancer Ther. 5, 2931-2945
   Abstract »    Full Text »    PDF »
Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts.
W.-H. Chan (2006)
Hum. Reprod. 21, 2985-2995
   Abstract »    Full Text »    PDF »
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.
J. Dai, D. Chen, R. A. Jones, L. H. Hurley, and D. Yang (2006)
Nucleic Acids Res. 34, 5133-5144
   Abstract »    Full Text »    PDF »
Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival..
L.-Y. Li, M.-Y. Liu, H.-M. Shih, C.-H. Tsai, and J.-Y. Chen (2006)
J. Gen. Virol. 87, 2869-2878
   Abstract »    Full Text »    PDF »
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite.
I. Tommasini, A. Guidarelli, L. Palomba, L. Cerioni, and O. Cantoni (2006)
J. Leukoc. Biol. 80, 929-938
   Abstract »    Full Text »    PDF »
Bcl-xL Is Overexpressed in Hormone-Resistant Prostate Cancer and Promotes Survival of LNCaP Cells via Interaction with Proapoptotic Bak.
C. Castilla, B. Congregado, D. Chinchon, F. J. Torrubia, M. A. Japon, and C. Saez (2006)
Endocrinology 147, 4960-4967
   Abstract »    Full Text »    PDF »
Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.
M. Tiwari, A. Kumar, R. A. Sinha, A. Shrivastava, A. K. Balapure, R. Sharma, V. K. Bajpai, K. Mitra, S. Babu, and M. M. Godbole (2006)
Carcinogenesis 27, 2047-2058
   Abstract »    Full Text »    PDF »
Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus ankara and vaccinia virus..
A. Chahroudi, D. A. Garber, P. Reeves, L. Liu, D. Kalman, and M. B. Feinberg (2006)
J. Virol. 80, 8469-8481
   Abstract »    Full Text »    PDF »
Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice..
R. Aneja, J. Zhou, B. Zhou, R. Chandra, and H. C. Joshi (2006)
Mol. Cancer Ther. 5, 2366-2377
   Abstract »    Full Text »    PDF »
Fibroblast Growth Factor-2 and Receptor-1{alpha}(IIIc) Regulate Postnatal Rat Lung Cell Apoptosis.
M. Yi, R. Belcastro, S. Shek, D. Luo, M. Post, and A. K. Tanswell (2006)
Am. J. Respir. Crit. Care Med. 174, 581-589
   Abstract »    Full Text »    PDF »
Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
Y. Cao, S. Adhikari, A. D. Ang, P. K. Moore, and M. Bhatia (2006)
Am J Physiol Cell Physiol 291, C503-C510
   Abstract »    Full Text »    PDF »
Glutamate Inhibits Chondral Mineralization through Apoptotic Cell Death Mediated by Retrograde Operation of the Cystine/Glutamate Antiporter.
L. Wang, E. Hinoi, A. Takemori, N. Nakamichi, and Y. Yoneda (2006)
J. Biol. Chem. 281, 24553-24565
   Abstract »    Full Text »    PDF »
Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis.
O. Yasuda, K. Fukuo, X. Sun, M. Nishitani, T. Yotsui, M. Higuchi, T. Suzuki, H. Rakugi, O. Smithies, N. Maeda, et al. (2006)
J. Biol. Chem. 281, 23899-23907
   Abstract »    Full Text »    PDF »
Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.
B. Becattini, C. Culmsee, M. Leone, D. Zhai, X. Zhang, K. J. Crowell, M. F. Rega, S. Landshamer, J. C. Reed, N. Plesnila, et al. (2006)
PNAS 103, 12602-12606
   Abstract »    Full Text »    PDF »
Protein Phosphatase 2A Enhances the Proapoptotic Function of Bax through Dephosphorylation.
M. Xin and X. Deng (2006)
J. Biol. Chem. 281, 18859-18867
   Abstract »    Full Text »    PDF »
Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival.
X. Deng, F. Gao, T. Flagg, J. Anderson, and W. S. May (2006)
Mol. Cell. Biol. 26, 4421-4434
   Abstract »    Full Text »    PDF »
Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes: effect of the pretreatment with eicosapentaenoic Acid..
N. Shimojo, S. Jesmin, S. Zaedi, M. Soma, S. Maeda, I. Yamaguchi, K. Goto, and T. Miyauchi (2006)
Experimental Biology and Medicine 231, 932-936
   Abstract »    Full Text »    PDF »
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.
L. H. Meyer, L. Karawajew, M. Schrappe, W.-D. Ludwig, K.-M. Debatin, and K. Stahnke (2006)
Blood 107, 4524-4531
   Abstract »    Full Text »    PDF »
Oncogenic Ras Inhibits Anoikis of Intestinal Epithelial Cells by Preventing the Release of a Mitochondrial Pro-apoptotic Protein Omi/HtrA2 into the Cytoplasm.
Z. Liu, H. Li, M. Derouet, A. Berezkin, T. Sasazuki, S. Shirasawa, and K. Rosen (2006)
J. Biol. Chem. 281, 14738-14747
   Abstract »    Full Text »    PDF »
Fas Signaling Induces Raft Coalescence That Is Blocked by Cholesterol Depletion in Human RPE Cells Undergoing Apoptosis.
J. E. Lincoln, M. Boling, A. N. Parikh, Y. Yeh, D. G. Gilchrist, and L. S. Morse (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2172-2178
   Abstract »    Full Text »    PDF »
Celastrol, a Triterpene Extracted from the Chinese "Thunder of God Vine," Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice..
H. Yang, D. Chen, Q. C. Cui, X. Yuan, and Q. P. Dou (2006)
Cancer Res. 66, 4758-4765
   Abstract »    Full Text »    PDF »
Roles of Apoptosis in Airway Epithelia.
Y. Tesfaigzi (2006)
Am. J. Respir. Cell Mol. Biol. 34, 537-547
   Abstract »    Full Text »    PDF »
The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits..
C. Wang, D. A. Neff, J. G. Krolikowski, D. Weihrauch, M. Bienengraeber, D. C. Warltier, J. R. Kersten, and P. S. Pagel (2006)
Anesth. Analg. 102, 1355-1360
   Abstract »    Full Text »    PDF »
RNA Aptamers Targeting the Cell Death Inhibitor CED-9 Induce Cell Killing in Caenorhabditis elegans.
C. Yang, N. Yan, J. Parish, X. Wang, Y. Shi, and D. Xue (2006)
J. Biol. Chem. 281, 9137-9144
   Abstract »    Full Text »    PDF »
The association between polycystic ovaries and endometrial cancer.
O.C. Pillay, L.F. W. Te Fong, J.C. Crow, E. Benjamin, T. Mould, W. Atiomo, P.A. Menon, A.J. Leonard, and P. Hardiman (2006)
Hum. Reprod. 21, 924-929
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)