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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1322 - 1326
DOI: 10.1126/science.281.5381.1322
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Review

The Bcl-2 Protein Family: Arbiters of Cell Survival

Jerry M. Adams, Suzanne Cory

REVIEW

Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens. Those most similar to Bcl-2 promote cell survival by inhibiting adapters needed for activation of the proteases (caspases) that dismantle the cell. More distant relatives instead promote apoptosis, apparently through mechanisms that include displacing the adapters from the pro-survival proteins. Thus, for many but not all apoptotic signals, the balance between these competing activities determines cell fate. Bcl-2 family members are essential for maintenance of major organ systems, and mutations affecting them are implicated in cancer.

The authors are at the Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia.

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Androgen and its receptor promote bax-mediated apoptosis..
Y. Lin, J. Kokontis, F. Tang, B. Godfrey, S. Liao, A. Lin, Y. Chen, and J. Xiang (2006)
Mol. Cell. Biol. 26, 1908-1916
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Molecular Targeting of BCL2 and BCLXL Proteins by Synthetic BCL2 Homology 3 Domain Peptide Enhances the Efficacy of Chemotherapy.
S. S. Dharap, P. Chandna, Y. Wang, J. J. Khandare, B. Qiu, S. Stein, and T. Minko (2006)
J. Pharmacol. Exp. Ther. 316, 992-998
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