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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1312 - 1316
DOI: 10.1126/science.281.5381.1312
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Review

Caspases: Enemies Within

Nancy A. Thornberry, Yuri Lazebnik

REVIEW

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

N. A. Thornberry is in the Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA. Y. Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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STAT1 Activation Causes Translocation of Bax to the Endoplasmic Reticulum during the Resolution of Airway Mucous Cell Hyperplasia by IFN-{gamma}.
B. A. Stout, K. Melendez, J. Seagrave, M. J. Holtzman, B. Wilson, J. Xiang, and Y. Tesfaigzi (2007)
J. Immunol. 178, 8107-8116
   Abstract »    Full Text »    PDF »
Caspase-Dependent Apoptosis in Light-Induced Retinal Degeneration.
O. Perche, M. Doly, and I. Ranchon-Cole (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2753-2759
   Abstract »    Full Text »    PDF »
Knockdown of Actin and Caspase Gene Expression by RNA Interference in the Symbiotic Anemone Aiptasia pallida.
S. R. Dunn, W. S. Phillips, D. R. Green, and V. M. Weis (2007)
Biol. Bull. 212, 250-258
   Abstract »    Full Text »    PDF »
Specific Amino Acid Dependency Regulates the Cellular Behavior of Melanoma.
Y.-M. Fu and G. G. Meadows (2007)
J. Nutr. 137, 1591S-1596S
   Abstract »    Full Text »    PDF »
Apoptotic signaling induces hyperpermeability following hemorrhagic shock.
E. W. Childs, B. Tharakan, F. A. Hunter, J. H. Tinsley, and X. Cao (2007)
Am J Physiol Heart Circ Physiol 292, H3179-H3189
   Abstract »    Full Text »    PDF »
Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation.
G. Zheng, J. Chen, K. Stefflova, M. Jarvi, H. Li, and B. C. Wilson (2007)
PNAS 104, 8989-8994
   Abstract »    Full Text »    PDF »
Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus.
L. Coen, K. Le Blay, I. Rowe, and B. A. Demeneix (2007)
PNAS 104, 8502-8507
   Abstract »    Full Text »    PDF »
Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development.
J. T. Felix, M. Magarinos, and F. J. Diaz-Benjumea (2007)
Development 134, 1845-1852
   Abstract »    Full Text »    PDF »
Reduced Photoreceptor Damage after Photodynamic Therapy through Blockade of Nitric Oxide Synthase in a Model of Choroidal Neovascularization.
H. She, T. Nakazawa, A. Matsubara, T. Hisatomi, T. A. Young, N. Michaud, E. Connolly, A. Hafezi-Moghadam, E. S. Gragoudas, and J. W. Miller (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2268-2277
   Abstract »    Full Text »    PDF »
Divergent Mechanisms of Glucocorticoid Resistance in Experimental Models of Pediatric Acute Lymphoblastic Leukemia.
P. S. Bachmann, R. Gorman, R. A. Papa, J. E. Bardell, J. Ford, U. R. Kees, G. M. Marshall, and R. B. Lock (2007)
Cancer Res. 67, 4482-4490
   Abstract »    Full Text »    PDF »
Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells.
K. M.A. Rogers, M. Thomas, L. Galligan, T. R. Wilson, W. L. Allen, H. Sakai, P. G. Johnston, and D. B. Longley (2007)
Mol. Cancer Ther. 6, 1544-1551
   Abstract »    Full Text »    PDF »
Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak.
Y.-A. Kim, D. Xiao, H. Xiao, A. A. Powolny, K. L. Lew, M. L. Reilly, Y. Zeng, Z. Wang, and S. V. Singh (2007)
Mol. Cancer Ther. 6, 1599-1609
   Abstract »    Full Text »    PDF »
Caspase activity during cell stasis: avoidance of apoptosis in an invertebrate extremophile, Artemia franciscana.
M. A. Menze and S. C. Hand (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R2039-R2047
   Abstract »    Full Text »    PDF »


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