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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1312 - 1316
DOI: 10.1126/science.281.5381.1312
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Review

Caspases: Enemies Within

Nancy A. Thornberry, Yuri Lazebnik

REVIEW

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

N. A. Thornberry is in the Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA. Y. Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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HAX-1 Represses Postmitochondrial Caspase-9 Activation and Cell Death During Hypoxia-Reoxygenation.
J. Shaw and L. A. Kirshenbaum (2006)
Circ. Res. 99, 336-338
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Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis.
O. Yasuda, K. Fukuo, X. Sun, M. Nishitani, T. Yotsui, M. Higuchi, T. Suzuki, H. Rakugi, O. Smithies, N. Maeda, et al. (2006)
J. Biol. Chem. 281, 23899-23907
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Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis..
C. Brignole, D. Marimpietri, F. Pastorino, B. Nico, D. Di Paolo, M. Cioni, F. Piccardi, M. Cilli, A. Pezzolo, M. V. Corrias, et al. (2006)
J Natl Cancer Inst 98, 1142-1157
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