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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1305 - 1308
DOI: 10.1126/science.281.5381.1305
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Review

Death Receptors: Signaling and Modulation

Avi Ashkenazi, Vishva M. Dixit

REVIEW

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

The authors are in the Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. E-mail: aa{at}gene.com, dixit{at}gene.com

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Cordyceps sinensis Mycelium Extract Induces Human Premyelocytic Leukemia Cell Apoptosis Through Mitochondrion Pathway.
Q. X. Zhang and J. Y. Wu (2007)
Experimental Biology and Medicine 232, 52-57
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TRAIL Induces Receptor-Interacting Protein 1-Dependent and Caspase-Dependent Necrosis-Like Cell Death under Acidic Extracellular Conditions.
O. Meurette, A. Rebillard, L. Huc, G. Le Moigne, D. Merino, O. Micheau, D. Lagadic-Gossmann, and M.-T. Dimanche-Boitrel (2007)
Cancer Res. 67, 218-226
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Is caspase-dependent apoptosis only cell differentiation taken to the extreme?.
P. Fernando and L. A. Megeney (2007)
FASEB J 21, 8-17
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Identification of apoptotic genes mediating TGF-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach.
Y. Cao, L. Chen, W. Zhang, Y. Liu, H. T. Papaconstantinou, C. R. Bush, C. M. Townsend Jr., E. A. Thompson, and T. C. Ko (2007)
Am J Physiol Gastrointest Liver Physiol 292, G28-G38
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Cytokine Response Modifier A Inhibition of Initiator Caspases Results in Covalent Complex Formation and Dissociation of the Caspase Tetramer.
J. Dobo, R. Swanson, G. S. Salvesen, S. T. Olson, and P. G. W. Gettins (2006)
J. Biol. Chem. 281, 38781-38790
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Activation of Caspase-8 and Caspase-12 Pathways by 7-Ketocholesterol in Human Retinal Pigment Epithelial Cells.
S. Luthra, B. Fardin, J. Dong, D. Hertzog, S. Kamjoo, S. Gebremariam, V. Butani, R. Narayanan, J. K. Mungcal, B. D. Kuppermann, et al. (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5569-5575
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Adrenomedullin 2 Antagonist Infusion to Rats During Midgestation Causes Fetoplacental Growth Restriction Through Apoptosis.
M. Chauhan, U. Yallampalli, L. Reed, and C. Yallampalli (2006)
Biol Reprod 75, 940-947
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HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-{alpha} in cerebral vascular endothelial cells.
S. Basuroy, S. Bhattacharya, D. Tcheranova