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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1305 - 1308
DOI: 10.1126/science.281.5381.1305
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Review

Death Receptors: Signaling and Modulation

Avi Ashkenazi, Vishva M. Dixit

REVIEW

Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.

The authors are in the Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. E-mail: aa{at}gene.com, dixit{at}gene.com

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M. V. Richter and D. J. Topham (2007)
J. Immunol. 179, 5054-5063
   Abstract »    Full Text »    PDF »
A Fas-Associated Death Domain Protein/Caspase-8-Signaling Axis Promotes S-Phase Entry and Maintains S6 Kinase Activity in T Cells Responding to IL-2.
A. F. Arechiga, B. D. Bell, S. Leverrier, B. M. Weist, M. Porter, Z. Wu, Y. Kanno, S. J. Ramos, S. T. Ong, R. Siegel, et al. (2007)
J. Immunol. 179, 5291-5300
   Abstract »    Full Text »    PDF »
Benzo[a]pyrene Induces Apoptosis in RL95-2 Human Endometrial Cancer Cells by Cytochrome P450 1A1 Activation.
J. Y. Kim, J.-Y. Chung, J.-E. Park, S. G. Lee, Y.-J. Kim, M.-S. Cha, M. S. Han, H.-J. Lee, Y. H. Yoo, and J.-M. Kim (2007)
Endocrinology 148, 5112-5122
   Abstract »    Full Text »    PDF »
Fas Ligand Delivery by a Prostate-Restricted Replicative Adenovirus Enhances Safety and Antitumor Efficacy.
X. Li, Y.-H. Liu, Y.-P. Zhang, S. Zhang, X. Pu, T. A. Gardner, M.-H. Jeng, and C. Kao (2007)
Clin. Cancer Res. 13, 5463-5473
   Abstract »    Full Text »    PDF »
Bortezomib Sensitizes Non Hodgkin's Lymphoma Cells to Apoptosis Induced by Antibodies to Tumor Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL) Receptors TRAIL-R1 and TRAIL-R2.
M. R. Smith, F. Jin, and I. Joshi (2007)
Clin. Cancer Res. 13, 5528s-5534s
   Abstract »    Full Text »    PDF »
Deletion of tumor necrosis factor death receptor inhibits amyloid {beta} generation and prevents learning and memory deficits in Alzheimer's mice.
P. He, Z. Zhong, K. Lindholm, L. Berning, W. Lee, C. Lemere, M. Staufenbiel, R. Li, and Y. Shen (2007)
J. Cell Biol. 178, 829-841
   Abstract »    Full Text »    PDF »
Ribotoxic Stress Sensitizes Glioblastoma Cells to Death Receptor Induced Apoptosis: Requirements for c-Jun NH2-Terminal Kinase and Bim.
S. Xia, Y. Li, E. M. Rosen, and J. Laterra (2007)
Mol. Cancer Res. 5, 783-792
   Abstract »    Full Text »    PDF »
Protein Kinase PKR Plays a Stimulus- and Virus-Dependent Role in Apoptotic Death and Virus Multiplication in Human Cells.
P. Zhang and C. E. Samuel (2007)
J. Virol. 81, 8192-8200
   Abstract »    Full Text »    PDF »
Phosphorylated Galectin-3 Mediates Tumor Necrosis Factor-related Apoptosis-inducing Ligand Signaling by Regulating Phosphatase and Tensin Homologue Deleted on Chromosome 10 in Human Breast Carcinoma Cells.
N. Mazurek, Y. J. Sun, K.-F. Liu, M. Z. Gilcrease, W. Schober, P. Nangia-Makker, A. Raz, and R. S. Bresalier (2007)
J. Biol. Chem. 282, 21337-21348
   Abstract »    Full Text »    PDF »
Dendritic Cells Infected with vpr-Positive Human Immunodeficiency Virus Type 1 Induce CD8+ T-Cell Apoptosis via Upregulation of Tumor Necrosis Factor Alpha.
B. Majumder, N. J. Venkatachari, E. A. Schafer, M. L. Janket, and V. Ayyavoo (2007)
J. Virol. 81, 7388-7399
   Abstract »    Full Text »    PDF »
The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.
H. A. Elrod, Y.-D. Lin, P. Yue, X. Wang, S. Lonial, F. R. Khuri, and S.-Y. Sun (2007)
Mol. Cancer Ther. 6, 2029-2038
   Abstract »    Full Text »    PDF »
The Farnesyltransferase Inhibitor Lonafarnib Induces CCAAT/Enhancer-binding Protein Homologous Protein-dependent Expression of Death Receptor 5, Leading to Induction of Apoptosis in Human Cancer Cells.
S.-Y. Sun, X. Liu, W. Zou, P. Yue, A. I. Marcus, and F. R. Khuri (2007)
J. Biol. Chem. 282, 18800-18809
   Abstract »    Full Text »    PDF »
Tunicamycin Sensitizes Human Melanoma Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Up-regulation of TRAIL-R2 via the Unfolded Protein Response.
C. C. Jiang, L. H. Chen, S. Gillespie, K. A. Kiejda, N. Mhaidat, Y. F. Wang, R. Thorne, X. D. Zhang, and P. Hersey (2007)
Cancer Res. 67, 5880-5888
   Abstract »    Full Text »    PDF »
Restoration of Tissue Factor Pathway Inhibitor-2 in a Human Glioblastoma Cell Line Triggers Caspase-Mediated Pathway and Apoptosis.
J. George, C. S. Gondi, D. H. Dinh, M. Gujrati, and J. S. Rao (2007)
Clin. Cancer Res. 13, 3507-3517
   Abstract »    Full Text »    PDF »
Phosphatidylinositol 3-kinase/nuclear factor-{kappa}B signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein expression in cultured FRTL thyroid cells.
M. Ren, Q. Guan, X. Zhong, B. Gong, Y. Sun, W. Xin, J. Guo, H. Wang, L. Gao, and J. Zhao (2007)
J. Mol. Endocrinol. 38, 619-625
   Abstract »    Full Text »    PDF »


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