Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 August 1998:
Vol. 281. no. 5380, pp. 1191 - 1193
DOI: 10.1126/science.281.5380.1191
Prev | Table of Contents | Next

Reports

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

David H. Munn, Min Zhou, John T. Attwood, Igor Bondarev, Simon J. Conway, Brendan Marshall, Corrie Brown, Andrew L. Mellor *

In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.

D. H. Munn, M. Zhou, J. T. Attwood, I. Bondarev, S. J. Conway, B. Marshall, A. L. Mellor, Programs in Molecular Immunology and Developmental Biology, Institute of Molecular Medicine and Genetics, and Department of Pediatrics, Medical College of Georgia (MCG), 1120 15th Street, Augusta, GA 30912, USA. C. Brown, Department of Pathology, University of Georgia, Athens, GA 30602, USA.
*   To whom correspondence should be addressed. E-mail: mellor{at}immag.mcg.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells.
D. J. Chung, M. Rossi, E. Romano, J. Ghith, J. Yuan, D. H. Munn, and J. W. Young (2009)
Blood 114, 555-563
   Abstract »    Full Text »    PDF »
Reduced Cytotoxic Function of Effector CD8+ T Cells Is Responsible for Indoleamine 2,3-Dioxygenase-Dependent Immune Suppression.
H. Liu, L. Liu, K. Liu, P. Bizargity, W. W. Hancock, and G. A. Visner (2009)
J. Immunol. 183, 1022-1031
   Abstract »    Full Text »    PDF »
Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase-Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer.
F. Qian, J. Villella, P. K. Wallace, P. Mhawech-Fauceglia, J. D. Tario Jr., C. Andrews, J. Matsuzaki, D. Valmori, M. Ayyoub, P. J. Frederick, et al. (2009)
Cancer Res. 69, 5498-5504
   Abstract »    Full Text »    PDF »
Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells.
M. Brenk, M. Scheler, S. Koch, J. Neumann, O. Takikawa, G. Hacker, T. Bieber, and D. von Bubnoff (2009)
J. Immunol. 183, 145-154
   Abstract »    Full Text »    PDF »
The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity.
G. N. Scott, J. DuHadaway, E. Pigott, N. Ridge, G. C. Prendergast, A. J. Muller, and L. Mandik-Nayak (2009)
J. Immunol. 182, 7509-7517
   Abstract »    Full Text »    PDF »
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
J. C. Schefold, J.-P. Zeden, C. Fotopoulou, S. von Haehling, R. Pschowski, D. Hasper, H.-D. Volk, C. Schuett, and P. Reinke (2009)
Nephrol. Dial. Transplant. 24, 1901-1908
   Abstract »    Full Text »    PDF »
Human Pregnancy Up-Regulates Tim-3 in Innate Immune Cells for Systemic Immunity.
J. Zhao, Z. Lei, Y. Liu, B. Li, L. Zhang, H. Fang, C. Song, X. Wang, G.-M. Zhang, Z.-H. Feng, et al. (2009)
J. Immunol. 182, 6618-6624
   Abstract »    Full Text »    PDF »
IFN-{gamma}-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo.
Y. H. Kim, B. K. Choi, W. J. Kang, K. H. Kim, S. W. Kang, A. L. Mellor, D. H. Munn, and B. S. Kwon (2009)
J. Leukoc. Biol. 85, 817-825
   Abstract »    Full Text »    PDF »
Immunomodulatory effects of Vitamin D in multiple sclerosis.
J. Correale, M. C. Ysrraelit, and M. I. Gaitan (2009)
Brain 132, 1146-1160
   Abstract »    Full Text »    PDF »
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology.
A. Curti, S. Trabanelli, V. Salvestrini, M. Baccarani, and R. M. Lemoli (2009)
Blood 113, 2394-2401
   Abstract »    Full Text »    PDF »
Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2h4 Mice from Developing Autoimmune Thyroiditis.
M. Nakahara, Y. Nagayama, O. Saitoh, R. Sogawa, S. Tone, and N. Abiru (2009)
Endocrinology 150, 1545-1551
   Abstract »    Full Text »    PDF »
Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior.
J. C. O'Connor, M. A. Lawson, C. Andre, E. M. Briley, S. S. Szegedi, J. Lestage, N. Castanon, M. Herkenham, R. Dantzer, and K. W. Kelley (2009)
J. Immunol. 182, 3202-3212
   Abstract »    Full Text »    PDF »
A Review of Candidate Pathways Underlying the Association Between Asthma and Major Depressive Disorder.
R. J. Van Lieshout, J. Bienenstock, and G. M. MacQueen (2009)
Psychosom Med 71, 187-195
   Abstract »    Full Text »    PDF »
Paracrine effects of uterine leucocytes on gene expression of human uterine stromal fibroblasts.
A. Germeyer, A. M. Sharkey, M. Prasadajudio, R. Sherwin, A. Moffett, K. Bieback, S. Clausmeyer, L. Masters, R. M. Popovici, A. P. Hess, et al. (2009)
Mol. Hum. Reprod. 15, 39-48
   Abstract »    Full Text »    PDF »
IFN-{gamma} Dictates Allograft Fate via Opposing Effects on the Graft and on Recipient CD8 T Cell Responses.
S. M. Coley, M. L. Ford, S. C. Hanna, M. E. Wagener, A. D. Kirk, and C. P. Larsen (2009)
J. Immunol. 182, 225-233
   Abstract »    Full Text »    PDF »
Mouse Pancreatic Islets Are Resistant to Indoleamine 2,3 Dioxygenase-Induced General Control Nonderepressible-2 Kinase Stress Pathway and Maintain Normal Viability and Function.
R. B. Jalili, F. Forouzandeh, A. Moeenrezakhanlou, G. R. Rayat, R. V. Rajotte, H. Uludag, and A. Ghahary (2009)
Am. J. Pathol. 174, 196-205
   Abstract »    Full Text »    PDF »
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.
C. Orabona, M. T. Pallotta, C. Volpi, F. Fallarino, C. Vacca, R. Bianchi, M. L. Belladonna, M. C. Fioretti, U. Grohmann, and P. Puccetti (2008)
PNAS 105, 20828-20833
   Abstract »    Full Text »    PDF »
Cell Cycle Arrest by Kynurenine in Lens Epithelial Cells.
M. Mailankot, D. Smith, S. Howell, B. Wang, J. W. Jacobberger, T. Stefan, and R. H. Nagaraj (2008)
Invest. Ophthalmol. Vis. Sci. 49, 5466-5475
   Abstract »    Full Text »    PDF »
High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.
M. E.D. Chamuleau, A. A. van de Loosdrecht, C. J. Hess, J. J.W.M. Janssen, A. Zevenbergen, R. Delwel, P. J.M. Valk, B. Lowenberg, and G. J. Ossenkoppele (2008)
Haematologica 93, 1894-1898
   Abstract »    Full Text »    PDF »
Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFN{gamma}.
A. M. Gasparri, E. Jachetti, B. Colombo, A. Sacchi, F. Curnis, G.-P. Rizzardi, C. Traversari, M. Bellone, and A. Corti (2008)
Mol. Cancer Ther. 7, 3859-3866
   Abstract »    Full Text »    PDF »
T cell apoptosis at the maternal-fetal interface in early human pregnancy, involvement of galectin-1.
H. D. Kopcow, F. Rosetti, Y. Leung, D. S. J. Allan, J. L. Kutok, and J. L. Strominger (2008)
PNAS 105, 18472-18477
   Abstract »    Full Text »    PDF »
Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model.
N. Yoshida, K. Ino, Y. Ishida, H. Kajiyama, E. Yamamoto, K. Shibata, M. Terauchi, A. Nawa, H. Akimoto, O. Takikawa, et al. (2008)
Clin. Cancer Res. 14, 7251-7259
   Abstract »    Full Text »    PDF »
Characterization of a lymphocyte subset displaying a unique regulatory activity in human decidua.
H. Amsalem, A. Gaiger, S. Mizrahi, S. Yagel, and J. Rachmilewitz (2008)
Int. Immunol. 20, 1147-1154
   Abstract »    Full Text »    PDF »
Breast-Feeding and Its Role in Early Development of the Immune System in Infants: Consequences for Health Later in Life.
L. M'Rabet, A. P. Vos, G. Boehm, and J. Garssen (2008)
J. Nutr. 138, 1782S-1790S
   Full Text »    PDF »
From Oxygenase to Sleep.
O. Hayaishi (2008)
J. Biol. Chem. 283, 19165-19175
   Full Text »    PDF »
Vascular allografts are resistant to methicillin-resistant Staphylococcus aureus through indoleamine 2,3-dioxygenase in a murine model.
A. Saito, N. Motomura, K. Kakimi, K. Narui, N. Noguchi, M. Sasatsu, K. Kubo, Y. Koezuka, D. Takai, S. Ueha, et al. (2008)
J. Thorac. Cardiovasc. Surg. 136, 159-167
   Abstract »    Full Text »    PDF »
Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury.
K. Mohib, S. Wang, Q. Guan, A. L. Mellor, H. Sun, C. Du, and A. M. Jevnikar (2008)
Am J Physiol Renal Physiol 295, F226-F234
   Abstract »    Full Text »    PDF »
Cancer Immunology.
O. J. Finn (2008)
N. Engl. J. Med. 358, 2704-2715
   Full Text »    PDF »
Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy.
T. Tilburgs, D. L. Roelen, B. J. van der Mast, G. M. de Groot-Swings, C. Kleijburg, S. A. Scherjon, and F. H. Claas (2008)
J. Immunol. 180, 5737-5745
   Abstract »    Full Text »    PDF »
Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival.
K. Ino, E. Yamamoto, K. Shibata, H. Kajiyama, N. Yoshida, M. Terauchi, A. Nawa, T. Nagasaka, O. Takikawa, and F. Kikkawa (2008)
Clin. Cancer Res. 14, 2310-2317
   Abstract »    Full Text »    PDF »
Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype.
H. Wan, M. A. Versnel, L. M. E. Leijten, C. G. van Helden-Meeuwsen, D. Fekkes, P. J. M. Leenen, N. A. Khan, R. Benner, and R. C. M. Kiekens (2008)
J. Leukoc. Biol. 83, 894-901
   Abstract »    Full Text »    PDF »
Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality.
L. K. Jasperson, C. Bucher, A. Panoskaltsis-Mortari, P. A. Taylor, A. L. Mellor, D. H. Munn, and B. R. Blazar (2008)
Blood 111, 3257-3265
   Abstract »    Full Text »    PDF »
Cytokine knockouts in reproduction: the use of gene ablation to dissect roles of cytokines in reproductive biology.
W. V. Ingman and R. L. Jones (2008)
Hum. Reprod. Update 14, 179-192
   Abstract »    Full Text »    PDF »
Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.
Y. Uemura, M. Suzuki, T.-Y. Liu, Y. Narita, S. Hirata, H. Ohyama, O. Ishihara, and S. Matsushita (2008)
Int. Immunol. 20, 405-412
   Abstract »    Full Text »    PDF »
Spontaneous Renal Allograft Acceptance Associated with "Regulatory" Dendritic Cells and IDO.
C. H. Cook, A. A. Bickerstaff, J.-J. Wang, T. Nadasdy, P. Della Pelle, R. B. Colvin, and C. G. Orosz (2008)
J. Immunol. 180, 3103-3112
   Abstract »    Full Text »    PDF »
Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells.
S. Lob, A. Konigsrainer, R. Schafer, H.-G. Rammensee, G. Opelz, and P. Terness (2008)
Blood 111, 2152-2154
   Abstract »    Full Text »    PDF »
Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells.
O. Parolini, F. Alviano, G. P. Bagnara, G. Bilic, H.-J. Buhring, M. Evangelista, S. Hennerbichler, B. Liu, M. Magatti, N. Mao, et al. (2008)
Stem Cells 26, 300-311
   Abstract »    Full Text »    PDF »
New Potential Therapeutic Targets in Melanoma.
T. F. Gajewski, E. A. Grimm, B. J. Nickoloff, and A. T. Weeraratna (2008)
ASCO Educational Book 2008, 404-407
   Abstract »    Full Text »    PDF »
Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal Cell Carcinoma.
R. Riesenberg, C. Weiler, O. Spring, M. Eder, A. Buchner, T. Popp, M. Castro, R. Kammerer, O. Takikawa, R. A. Hatz, et al. (2007)
Clin. Cancer Res. 13, 6993-7002
   Abstract »    Full Text »    PDF »
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival.
J. Li, A. Meinhardt, M.-E. Roehrich, D. Golshayan, J. Dudler, M. Pagnotta, M. Trucco, and G. Vassalli (2007)
Am J Physiol Heart Circ Physiol 293, H3415-H3423
   Abstract »    Full Text »    PDF »
Characterization of the Kynurenine Pathway in Human Neurons.
G. J. Guillemin, K. M. Cullen, C. K. Lim, G. A. Smythe, B. Garner, V. Kapoor, O. Takikawa, and B. J. Brew (2007)
J. Neurosci. 27, 12884-12892
   Abstract »    Full Text »    PDF »
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.
T. Hayashi, J.-H. Mo, X. Gong, C. Rossetto, A. Jang, L. Beck, G. I. Elliott, I. Kufareva, R. Abagyan, D. H. Broide, et al. (2007)
PNAS 104, 18619-18624
   Abstract »    Full Text »    PDF »
Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO.
P. Krause, E. Singer, P. I. Darley, J. Klebensberger, M. Groettrup, and D. F. Legler (2007)
J. Leukoc. Biol. 82, 1106-1114
   Abstract »    Full Text »    PDF »
A Link between PDL1 and T Regulatory Cells in Fetomaternal Tolerance.
A. Habicht, S. Dada, M. Jurewicz, B. T. Fife, H. Yagita, M. Azuma, M. H. Sayegh, and I. Guleria (2007)
J. Immunol. 179, 5211-5219
   Abstract »    Full Text »    PDF »
Induction of Indoleamine 2,3-Dioxygenase in Vascular Smooth Muscle Cells by Interferon-{gamma} Contributes to Medial Immunoprivilege.
M. C. Cuffy, A. M. Silverio, L. Qin, Y. Wang, R. Eid, G. Brandacher, F. G. Lakkis, D. Fuchs, J. S. Pober, and G. Tellides (2007)
J. Immunol. 179, 5246-5254
   Abstract »    Full Text »    PDF »
Dendritic Cells: Key to Fetal Tolerance?.
S. M Blois, U. Kammerer, C. A. Soto, M. C Tometten, V. Shaikly, G. Barrientos, R. Jurd, D. Rukavina, A. W Thomson, B. F Klapp, et al. (2007)
Biol Reprod 77, 590-598
   Abstract »    Full Text »    PDF »
Failure at the Effector Phase: Immune Barriers at the Level of the Melanoma Tumor Microenvironment.
T. F. Gajewski (2007)
Clin. Cancer Res. 13, 5256-5261
   Abstract »    Full Text »    PDF »
Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN{gamma}R1 signaling and IDO expression.
F. Gieseke, B. Schutt, S. Viebahn, E. Koscielniak, W. Friedrich, R. Handgretinger, and I. Muller (2007)
Blood 110, 2197-2200
   Abstract »    Full Text »    PDF »
Expression of Indoleamine 2,3-Dioxygenase in Human Corneal Cells as a Local Immunosuppressive Factor.
Y.-H. Ryu and J.-C. Kim (2007)
Invest. Ophthalmol. Vis. Sci. 48, 4148-4152
   Abstract »    Full Text »    PDF »
Noncanonical NF-{kappa}B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.
S. W. Tas, M. J. Vervoordeldonk, N. Hajji, J. H. N. Schuitemaker, K. F. van der Sluijs, M. J. May, S. Ghosh, M. L. Kapsenberg, P. P. Tak, and E. C. de Jong (2007)
Blood 110, 1540-1549
   Abstract »    Full Text »    PDF »
Immune response to stem cells and strategies to induce tolerance.
P. Batten, N. A Rosenthal, and M. H Yacoub (2007)
Phil Trans R Soc B 362, 1343-1356
   Abstract »    Full Text »    PDF »
Bin1 Ablation Increases Susceptibility to Cancer during Aging, Particularly Lung Cancer.
M. Y. Chang, J. Boulden, J. B. Katz, L. Wang, T. J. Meyer, A. P. Soler, A. J. Muller, and G. C. Prendergast (2007)
Cancer Res. 67, 7605-7612
   Abstract »    Full Text »    PDF »
Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound D-1-Methyl-Tryptophan.
R. Metz, J. B. DuHadaway, U. Kamasani, L. Laury-Kleintop, A. J. Muller, and G. C. Prendergast (2007)
Cancer Res. 67, 7082-7087
   Abstract »    Full Text »    PDF »
Blockade of IDO Inhibits Nasal Tolerance Induction.
A. P. J. van der Marel, J. N. Samsom, M. Greuter, L. A. van Berkel, T. O'Toole, G. Kraal, and R. E. Mebius (2007)
J. Immunol. 179, 894-900
   Abstract »    Full Text »    PDF »
Foxp3+CD25+ T Regulatory Cells Stimulate IFN-{gamma}-Independent CD152-Mediated Activation of Tryptophan Catabolism That Provides Dendritic Cells with Immune Regulatory Activity in Mice Unresponsive to Staphylococcal Enterotoxin B.
P. Feunou, S. Vanwetswinkel, F. Gaudray, M. Goldman, P. Matthys, and M. Y. Braun (2007)
J. Immunol. 179, 910-917
   Abstract »    Full Text »    PDF »
Creating an Immune-Privileged Site Using Retinal Progenitor Cells and Biodegradable Polymers.
T. F. Ng, E. Lavik, H. Keino, A. W. Taylor, R. S. Langer, and M. J. Young (2007)
Stem Cells 25, 1552-1559
   Abstract »    Full Text »    PDF »
Transient Upregulation of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Human Chorionic Gonadotropin Downregulates Autoimmune Diabetes.
A. Ueno, S. Cho, L. Cheng, J. Wang, S. Hou, H. Nakano, P. Santamaria, and Y. Yang (2007)
Diabetes 56, 1686-1693
   Abstract »    Full Text »    PDF »
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.
A. Boasso, J.-P. Herbeuval, A. W. Hardy, S. A. Anderson, M. J. Dolan, D. Fuchs, and G. M. Shearer (2007)
Blood 109, 3351-3359
   Abstract »    Full Text »    PDF »
Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection.
E. Larrea, J. I. Riezu-Boj, L. Gil-Guerrero, N. Casares, R. Aldabe, P. Sarobe, M. P. Civeira, J. L. Heeney, C. Rollier, B. Verstrepen, et al. (2007)
J. Virol. 81, 3662-3666
   Abstract »    Full Text »    PDF »
Suppression of Memory CD8 T Cell Generation and Function by Tryptophan Catabolism.
Z. Liu, H. Dai, N. Wan, T. Wang, S. Bertera, M. Trucco, and Z. Dai (2007)
J. Immunol. 178, 4260-4266
   Abstract »    Full Text »    PDF »
Upregulation of Placental Indoleamine 2,3-Dioxygenase by Human Chorionic Gonadotropin.
Z.M. Lei, M. Yang, X. Li, O. Takikawa, and C.V. Rao (2007)
Biol Reprod 76, 639-644
   Abstract »    Full Text »    PDF »
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells.
A. Curti, S. Pandolfi, B. Valzasina, M. Aluigi, A. Isidori, E. Ferri, V. Salvestrini, G. Bonanno, S. Rutella, I. Durelli, et al. (2007)
Blood 109, 2871-2877
   Abstract »    Full Text »    PDF »
Maternal Acceptance of the Fetus: True Human Tolerance.
I. Guleria and M. H. Sayegh (2007)
J. Immunol. 178, 3345-3351
   Abstract »    Full Text »    PDF »
Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses.
D.-Y. Hou, A. J. Muller, M. D. Sharma, J. DuHadaway, T. Banerjee, M. Johnson, A. L. Mellor, G. C. Prendergast, and D. H. Munn (2007)
Cancer Res. 67, 792-801
   Abstract »    Full Text »    PDF »
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.
F. Forouhar, J. L. R. Anderson, C. G. Mowat, S. M. Vorobiev, A. Hussain, M. Abashidze, C. Bruckmann, S. J. Thackray, J. Seetharaman, T. Tucker, et al. (2007)
PNAS 104, 473-478
   Abstract »    Full Text »    PDF »
A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells.
W-H Zhu, C-Z Lu, Y-M Huang, H Link, and B-G Xiao (2007)
Multiple Sclerosis 13, 33-40
   Abstract »    PDF »
Kinetics of murine decidual dendritic cells.
A.-H. Zarnani, S.-M. Moazzeni, F. Shokri, M. Salehnia, and M. Jeddi-Tehrani (2007)
Reproduction 133, 275-283
   Abstract »    Full Text »    PDF »
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.
M. D. Chiesa, S. Carlomagno, G. Frumento, M. Balsamo, C. Cantoni, R. Conte, L. Moretta, A. Moretta, and M. Vitale (2006)
Blood 108, 4118-4125
   Abstract »    Full Text »    PDF »
A high-affinity, tryptophan-selective amino acid transport system in human macrophages.
R. L. Seymour, V. Ganapathy, A. L. Mellor, and D. H. Munn (2006)
J. Leukoc. Biol. 80, 1320-1327
   Abstract »    Full Text »    PDF »
Placenta-Derived Multipotent Cells Exhibit Immunosuppressive Properties That Are Enhanced in the Presence of Interferon-{gamma}.
C.-J. Chang, M.-L. Yen, Y.-C. Chen, C.-C. Chien, H.-I. Huang, C.-H. Bai, and B. L. Yen (2006)
Stem Cells 24, 2466-2477
   Abstract »    Full Text »    PDF »
Reinstalling Antitumor Immunity by Inhibiting Tumor-Derived Immunosuppressive Molecule IDO through RNA Interference.
X. Zheng, J. Koropatnick, M. Li, X. Zhang, F. Ling, X. Ren, X. Hao, H. Sun, C. Vladau, J. A. Franek, et al. (2006)
J. Immunol. 177, 5639-5646
   Abstract »    Full Text »    PDF »
Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C).
V. M. Abrahams, T. M. Schaefer, J. V. Fahey, I. Visintin, J. A. Wright, P. B. Aldo, R. Romero, C. R. Wira, and G. Mor (2006)
Hum. Reprod. 21, 2432-2439
   Abstract »    Full Text »    PDF »
In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes.
K.-D. Park, L. Marti, J. Kurtzberg, and P. Szabolcs (2006)
Blood 108, 1770-1773
   Abstract »    Full Text »    PDF »
Suppression of T-cell functions by human granulocyte arginase.
M. Munder, H. Schneider, C. Luckner, T. Giese, C.-D. Langhans, J. M. Fuentes, P. Kropf, I. Mueller, A. Kolb, M. Modolell, et al. (2006)
Blood 108, 1627-1634
   Abstract »    Full Text »    PDF »
1-Methyl-Tryptophan Can Interfere with TLR Signaling in Dendritic Cells Independently of IDO Activity.
S. Agaugue, L. Perrin-Cocon, F. Coutant, P. Andre, and V. Lotteau (2006)
J. Immunol. 177, 2061-2071
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2 Inhibitor Enhances the Efficacy of a Breast Cancer Vaccine: Role of IDO.
G. D. Basu, T. L. Tinder, J. M. Bradley, T. Tu, C. L. Hattrup, B. A. Pockaj, and P. Mukherjee (2006)
J. Immunol. 177, 2391-2402
   Abstract »    Full Text »    PDF »
Kynurenine Pathway Enzymes in Dendritic Cells Initiate Tolerogenesis in the Absence of Functional IDO.
M. L. Belladonna, U. Grohmann, P. Guidetti, C. Volpi, R. Bianchi, M. C. Fioretti, R. Schwarcz, F. Fallarino, and P. Puccetti (2006)
J. Immunol. 177, 130-137
   Abstract »    Full Text »    PDF »
CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
M. S. von Bergwelt-Baildon, A. Popov, T. Saric, J. Chemnitz, S. Classen, M. S. Stoffel, F. Fiore, U. Roth, M. Beyer, S. Debey, et al. (2006)
Blood 108, 228-237
   Abstract »    Full Text »    PDF »
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor {zeta}-Chain and Induce a Regulatory Phenotype in Naive T Cells..
F. Fallarino, U. Grohmann, S. You, B. C. McGrath, D. R. Cavener, C. Vacca, C. Orabona, R. Bianchi, M. L. Belladonna, C. Volpi, et al. (2006)
J. Immunol. 176, 6752-6761
   Abstract »    Full Text »    PDF »
Identification of Genetic Regions of Importance for Reproductive Performance in Female Mice.
M. Liljander, M.-A. Sallstrom, S. Andersson, P. Wernhoff, A. Andersson, R. Holmdahl, and R. Mattsson (2006)
Genetics 173, 901-909
   Abstract »    Full Text »    PDF »
System B0,+ amino acid transport regulates the penetration stage of blastocyst implantation with possible long-term developmental consequences through adulthood.
L. J. Van Winkle, J. K. Tesch, A. Shah, and A. L. Campione (2006)
Hum. Reprod. Update 12, 145-157
   Abstract »    Full Text »    PDF »
Novel Action of Indoleamine 2,3-Dioxygenase Attenuating Acute Lung Allograft Injury.
H. Liu, L. Liu, B. S. Fletcher, and G. A. Visner (2006)
Am. J. Respir. Crit. Care Med. 173, 566-572
   Abstract »    Full Text »    PDF »
Indoleamine 2,3-Dioxygenase Participates in the Interferon-gamma-Induced Cell Death Process in Cultured Bovine Luteal Cells.
M. J. Cannon and J. L. Pate (2006)
Biol Reprod 74, 552-559
   Abstract »    Full Text »    PDF »
Prognostic Value of Indoleamine 2,3-Dioxygenase Expression in Colorectal Cancer: Effect on Tumor-Infiltrating T Cells.
G. Brandacher, A. Perathoner, R. Ladurner, S. Schneeberger, P. Obrist, C. Winkler, E. R. Werner, G. Werner-Felmayer, H. G. Weiss, G. Gobel, et al. (2006)
Clin. Cancer Res. 12, 1144-1151
   Abstract »    Full Text »    PDF »
Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-{gamma}- and CD40L-mediated costimulation.
F. A. W. Verreck, T. de Boer, D. M. L. Langenberg, L. van der Zanden, and T. H. M. Ottenhoff (2006)
J. Leukoc. Biol. 79, 285-293
   Abstract »    Full Text »    PDF »
Estrogens and Glucocorticoids Have Opposing Effects on the Amount and Latent Activity of Complement Proteins in the Rat Uterus.
T. Rhen and J. A. Cidlowski (2006)
Biol Reprod 74, 265-274
   Abstract »    Full Text »    PDF »
Nitration and Inactivation of IDO by Peroxynitrite.
H. Fujigaki, K. Saito, F. Lin, S. Fujigaki, K. Takahashi, B. M. Martin, C. Y. Chen, J. Masuda, J. Kowalak, O. Takikawa, et al. (2006)
J. Immunol. 176, 372-379
   Abstract »    Full Text »    PDF »
Developmental factors as determinants of risk for infections and atopy in childhood.
P. G. Holt (2005)
Eur. Respir. Rev. 14, 69-73
   Abstract »    Full Text »    PDF »
The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy.
S. L. Straszewski-Chavez, V. M. Abrahams, and G. Mor (2005)
Endocr. Rev. 26, 877-897
   Abstract »    Full Text »    PDF »
IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-{gamma} increase in normal pregnancy but decrease in spontaneous abortion.
N. Miwa, S. Hayakawa, S. Miyazaki, S. Myojo, Y. Sasaki, M. Sakai, O. Takikawa, and S. Saito (2005)
Mol. Hum. Reprod. 11, 865-870
   Abstract »    Full Text »    PDF »
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite.
M. Platten, P. P. Ho, S. Youssef, P. Fontoura, H. Garren, E. M. Hur, R. Gupta, L. Y. Lee, B. A. Kidd, W. H. Robinson, et al. (2005)
Science 310, 850-855
   Abstract »    Full Text »    PDF »
Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.
F. Fallarino, C. Orabona, C. Vacca, R. Bianchi, S. Gizzi, C. Asselin-Paturel, M. C. Fioretti, G. Trinchieri, U. Grohmann, and P. Puccetti (2005)
Int. Immunol. 17, 1429-1438
   Abstract »    Full Text »    PDF »
Protection from Abortion by Heme Oxygenase-1 Up-Regulation Is Associated with Increased Levels of Bag-1 and Neuropilin-1 at the Fetal-Maternal Interface.
A. Sollwedel, A. Z. Bertoja, M. L. Zenclussen, K. Gerlof, U. Lisewski, P. Wafula, B. Sawitzki, C. Woiciechowsky, H.-D. Volk, and A. C. Zenclussen (2005)
J. Immunol. 175, 4875-4885
   Abstract »    Full Text »    PDF »
Th1 Cytokines Are Essential for Placental Immunity to Listeria monocytogenes.
E. M. Barber, M. Fazzari, and J. W. Pollard (2005)
Infect. Immun. 73, 6322-6331
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)