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Science 7 August 1998:
Vol. 281. no. 5378, pp. 835 - 838
DOI: 10.1126/science.281.5378.835
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Reports

Positive Selection Through a Motif in the alpha beta T Cell Receptor

B. Thomas Bäckström, * Urs Müller, Barbara Hausmann, Ed Palmer dagger

The two lineages of T cells, alpha beta and gamma delta , differ in their developmental requirements: only alpha beta T cells require major histocompatibility complex recognition, a process known as positive selection. The alpha beta T cell receptor (TCR), but not its gamma delta counterpart, contains a motif within the alpha -chain connecting peptide domain (alpha -CPM) that has been conserved over the last 500 million years. In transgenic mice expressing an alpha beta TCR lacking the alpha -CPM, thymocytes were blocked in positive selection but could undergo negative selection. Thus, the alpha -CPM seems to participate in the generation of signals required for positive selection.

Basel Institute for Immunology, CH-4005 Basel, Switzerland.
*   Present address: Malaghan Institute of Medical Research, Post Office Box 7060, Wellington South, New Zealand.

dagger    To whom correspondence should be addressed. E-mail: palmer{at}bii.ch

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