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Science 7 August 1998:
Vol. 281. no. 5378, pp. 814 - 818
DOI: 10.1126/science.281.5378.814
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Reports

Callosal Window Between Prefrontal Cortices: Cognitive Interaction to Retrieve Long-Term Memory

Isao Hasegawa, * Tetsuya Fukushima, Takeshi Ihara, Yasushi Miyashita

A perceptual image can be recalled from memory without sensory stimulation. However, the neural origin of memory retrieval remains unsettled. To examine whether memory retrieval can be regulated by top-down processes originating from the prefrontal cortex, a visual associative memory task was introduced into the partial split-brain paradigm in monkeys. Long-term memory acquired through stimulus-stimulus association did not transfer via the anterior corpus callosum, a key part interconnecting prefrontal cortices. Nonetheless, when a visual cue was presented to one hemisphere, the anterior callosum could instruct the other hemisphere to retrieve the correct stimulus specified by the cue. Thus, although visual long-term memory is stored in the temporal cortex, memory retrieval is under the executive control of the prefrontal cortex.

I. Hasegawa, Department of Physiology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, and Mind Articulation Project, ICORP, Japan Science and Technology Corporation, Yushima, Bunkyo-ku, Tokyo 113, Japan. T. Fukushima and T. Ihara, Department of Physiology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. Y. Miyashita, Department of Physiology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113; Mind Articulation Project, ICORP, Japan Science and Technology Corporation, Yushima, Bunkyo-ku, Tokyo 113; and National Institute for Physiological Sciences, Myodaiji, Okazaki, 444, Japan.
*   To whom correspondence should be addressed. E-mail: hasegawa{at}m.u-tokyo.ac.jp

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