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Science 31 July 1998:
Vol. 281. no. 5377, pp. 703 - 706
DOI: 10.1126/science.281.5377.703
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Reports

Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

Dawn M. Gross, Thomas Forsthuber, Magdalena Tary-Lehmann, Carey Etling, Kouichi Ito, Zoltan A. Nagy, Jodie A. Field, Allen C. Steere, Brigitte T. Huber

Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.

D. M. Gross and B. T. Huber, Department of Pathology, Tufts University, Boston, MA 02111 USA. T. Forsthuber, M. Tary-Lehmann, C. Etling, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4943, USA. K. Ito and Z. A. Nagy, Department of Immunology, Hoffmann-La Roche, Nutley, NJ 07110, USA. J. A. Field and A. C. Steere, Department of Rheumatology, New England Medical Center, Boston, MA 02111, USA.

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The Immunoglobulin (IgG) Antibody Response to OspA and OspB Correlates with Severe and Prolonged Lyme Arthritis and the IgG Response to P35 Correlates with Mild and Brief Arthritis.
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Possible Cause of Treatment-Resistant Lyme Arthritis.
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Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers.
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PNAS 97, 11433-11438
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