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Science 24 July 1998:
Vol. 281. no. 5376, pp. 568 - 572
DOI: 10.1126/science.281.5376.568
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Reports

An Unusual Mechanism for Ligand Antagonism

Chikako Torigoe, John K. Inman, Henry Metzger

The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand could hoard a critical initiating kinase, they prevented the outnumbered clusters engendered by the high-affinity ligands from launching the more complete cascade. A similar mechanism could explain the antagonistic action of some peptides on the activation of T cells.

C. Torigoe and H. Metzger, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA. J. K. Inman, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA.

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