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Science 17 July 1998:
Vol. 281. no. 5375, pp. 409 - 413
DOI: 10.1126/science.281.5375.409
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Reports

Boundary Formation in Drosophila Wing: Notch Activity Attenuated by the POU Protein Nubbin

Carl J. Neumann, * Stephen M. Cohen dagger

Cell interactions mediated by Notch-family receptors have been implicated in the specification of tissue boundaries in vertebrate and insect development. Although Notch ligands are often widely expressed, tightly localized activation of Notch is critical for the formation of sharp boundaries. Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral boundary in the Drosophila wing. Nubbin represses Notch-dependent target genes and sets a threshold for Notch activity that defines the spatial domain of boundary-specific gene expression.

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
*   Present address: MPI for Developmental Biology, D-72076 Tubingen, Germany.

dagger    To whom correspondence should be addressed. E-mail: scohen{at}embl-heidelberg.de

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dynamical Analysis of the Regulatory Network Defining the Dorsal-Ventral Boundary of the Drosophila Wing Imaginal Disc.
A. Gonzalez, C. Chaouiya, and D. Thieffry (2006)
Genetics 174, 1625-1634
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Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage.
R. Grosskortenhaus, K. J. Robinson, and C. Q. Doe (2006)
Genes & Dev. 20, 2618-2627
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Hypothesis Testing in Evolutionary Developmental Biology: A Case Study from Insect Wings.
E. L. Jockusch and K. A. Ober (2004)
J. Hered. 95, 382-396
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defective proventriculus is required for pattern formation along the proximodistal axis, cell proliferation and formation of veins in the Drosophila wing.
S. Kolzer, B. Fuss, M. Hoch, and T. Klein (2003)
Development 130, 4135-4147
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Context-dependent utilization of Notch activity in Drosophila glial determination.
Y. Umesono, Y. Hiromi, and Y. Hotta (2003)
Development 129, 2391-2399
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Repression of Teashirt marks the initiation of wing development.
J. Wu and S. M. Cohen (2003)
Development 129, 2411-2418
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Genetic requirements of vestigial in the regulation of Drosophila wing development.
L. A. Baena-Lopez and A. Garcia-Bellido (2003)
Development 130, 197-208
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Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge.
D. d. A. Rodriguez, J. Terriente, M. I. Galindo, J. P. Couso, and F. J. Diaz-Benjumea (2002)
Development 129, 3995-4004
   Abstract »    Full Text »    PDF »
Temporal regulation of apterous activity during development of the Drosophila wing.
M Milan and S. Cohen (2000)
Development 127, 3069-3078
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Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila.
N Lawrence, T Klein, K Brennan, and A Martinez Arias (2000)
Development 127, 3185-3195
   Abstract »    PDF »
A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila.
F Casares and R. Mann (2000)
Development 127, 1499-1508
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Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity.
S Zaffran and M Frasch (2000)
Development 127, 1115-1130
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A Screen for Identifying Genes Interacting With Armadillo, the Drosophila Homolog of {beta}-Catenin.
S. Greaves, B. Sanson, P. White, and J.-P. Vincent (1999)
Genetics 153, 1753-1766
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Notch Signaling: Cell Fate Control and Signal Integration in Development.
S. Artavanis-Tsakonas, M. D. Rand, and R. J. Lake (1999)
Science 284, 770-776
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Sprouty is a general inhibitor of receptor tyrosine kinase signaling.
A Reich, A Sapir, and B Shilo (1999)
Development 126, 4139-4147
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