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Science 3 July 1998:
Vol. 281. no. 5373, pp. 96 - 99
DOI: 10.1126/science.281.5373.96
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Reports

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

Paul Garside, * Elizabeth Ingulli, * Rebecca R. Merica, Julia G. Johnson, Randolph J. Noelle, Marc K. Jenkins dagger

Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.

P. Garside, University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom. E. Ingulli, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA. R. R. Merica, J. G. Johnson, M. K. Jenkins, Department of Microbiology and the Center for Immunology at the University of Minneota Medical School, Minneapolis, MN 55455, USA. R. J. Noelle, Dartmouth Medical College, Department of Microbiology, Lebanon, NH, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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Cytokine Control of Memory B Cell Homing Machinery.
M. P. Roy, C. H. Kim, and E. C. Butcher (2002)
J. Immunol. 169, 1676-1682
   Abstract »    Full Text »    PDF »
A Role for Tumor Necrosis Factor-{alpha} in Remodeling the Splenic Marginal Zone during Leishmania donovani Infection.
C. R. Engwerda, M. Ato, S. E. J. Cotterell, T. L. Mynott, A. Tschannerl, P. M. A. Gorak-Stolinska, and P. M. Kaye (2002)
Am. J. Pathol. 161, 429-437
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Bound to B Cells: Relationship to Virus Replicating in CD4+ T Cells and Circulating in Plasma.
A. Malaspina, S. Moir, D. C. Nickle, E. T. Donoghue, K. M. Ogwaro, L. A. Ehler, S. Liu, J. A. M. Mican, M. Dybul, T.-W. Chun, et al. (2002)
J. Virol. 76, 8855-8863
   Abstract »    Full Text »    PDF »
Pivotal Role of Dendritic Cell-derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes.
H. Yoneyama, S. Narumi, Y. Zhang, M. Murai, M. Baggiolini, A. Lanzavecchia, T. Ichida, H. Asakura, and K. Matsushima (2002)
J. Exp. Med. 195, 1257-1266
   Abstract »    Full Text »    PDF »
B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion.
P. Yu, Y. Wang, R. K. Chin, L. Martinez-Pomares, S. Gordon, M. H. Kosco-Vibois, J. Cyster, and Y.-X. Fu (2002)
J. Immunol. 168, 5117-5123
   Abstract »    Full Text »    PDF »
Orally Tolerized T Cells Are Only Able to Enter B Cell Follicles Following Challenge with Antigen in Adjuvant, but They Remain Unable to Provide B Cell Help.
K. M. Smith, F. McAskill, and P. Garside (2002)
J. Immunol. 168, 4318-4325
   Abstract »    Full Text »    PDF »
Germinal Center B Cells Constitute a Predominant Physiological Source of IL-4: Implication for Th2 Development In Vivo.
B. Johansson-Lindbom and C. A. K. Borrebaeck (2002)
J. Immunol. 168, 3165-3172
   Abstract »    Full Text »    PDF »
Autoreactive T Cells Revealed in the Normal Repertoire: Escape from Negative Selection and Peripheral Tolerance.
J. Yan and M. J. Mamula (2002)
J. Immunol. 168, 3188-3194
   Abstract »    Full Text »    PDF »
Modeling the presentation of C3d-coated antigen by B lymphocytes: enhancement by CR1/2-BCR co-ligation is selective for the co-ligating antigen.
J. Prechl, D. C. Baiu, A. Horvath, and A. Erdei (2002)
Int. Immunol. 14, 241-247
   Abstract »    Full Text »    PDF »
CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals.
J. B. Chung, R. A. Sater, M. L. Fields, J. Erikson, and J. G. Monroe (2002)
Int. Immunol. 14, 157-166
   Abstract »    Full Text »    PDF »
Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State.
A. Bar-Or, E. M. L Oliveira, D. E. Anderson, J. I. Krieger, M. Duddy, K. C. O'Connor, and D. A. Hafler (2001)
J. Immunol. 167, 5669-5677
   Abstract »    Full Text »    PDF »
Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes"".
M. A. C. de Lafaille, S. Muriglan, M.-J. Sunshine, Y. Lei, N. Kutchukhidze, G. C. Furtado, A. K. Wensky, D. Olivares-Villagomez, and J. J. Lafaille (2001)
J. Exp. Med. 194, 1349-1360
   Abstract »    Full Text »    PDF »


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