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Science 19 June 1998:
Vol. 280. no. 5371, pp. 1880 - 1884
DOI: 10.1126/science.280.5371.1880
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Articles

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

Michael Emerman, * Michael H. Malim *

Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the intracellular trafficking of viral and host cell proteins. Detailed analysis of the interplay between these viral proteins and normal cellular activities has provided new insights into central questions of virology and host cell biology.

M. Emerman is in the Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North-Mailstop C2-023, Seattle, Washington 98109-1024, USA. E-mail: memerman{at}fhcrc.org. M. H. Malim is in the Department of Microbiology, Howard Hughes Medical Institute, University of Pennsylvania, 415 Curie Boulevard, Room 347B, Philadelphia, PA 19104-6148, USA. E-mail: malim{at}hhmi.upenn.edu
*   Address correspondence to either author.

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