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Science 19 June 1998:
Vol. 280. no. 5371, pp. 1868 - 1871
DOI: 10.1126/science.280.5371.1868
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Limitations of a Molecular Clock Applied to Considerations of the Origin of HIV-1

Bette Korber, James Theiler, Steven Wolinsky *

A recent report has provided information that helps to determine the age of a common viral ancestor of the AIDS epidemic. Korber et al. examine the strengths as well as limitations of molecular clock analysis and the implications of the findings for planning vaccines and forecasting the future of the epidemic.

B. Korber is in the Theoretical Division (T-10), Los Alamos National Laboratory, Los Alamos, NM 87545, USA, and is a visiting faculty member at the Santa Fe Institute, Santa Fe, NM 87501, USA. J. Theiler is in the Space and Remote Sensing Sciences Group (NIS-2), Los Alamos National Laboratory, Los Alamos, NM 87545, USA. S. Wolinsky is in the Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
*   To whom correspondence should be addressed.

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