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Science 12 June 1998:
Vol. 280. no. 5370, pp. 1750 - 1752
DOI: 10.1126/science.280.5370.1750
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Reports

Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

Hong Ming Shen, Andrew Peters, Beverly Baron, Xiangdong Zhu, Ursula Storb *

Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha -fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.

H. M. Shen and U. Storb, Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60617, USA.
A. Peters, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60617, USA.
B. Baron, Department of Pathology, University of Chicago, Chicago, IL 60617, USA.
X. Zhu, Department of Medicine, University of Chicago, Chicago, IL 60617, USA.
*   To whom correspondence should be addressed.

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