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Science 5 June 1998:
Vol. 280. no. 5369, pp. 1596 - 1599
DOI: 10.1126/science.280.5369.1596
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Reports

The Tetrameric Structure of a Glutamate Receptor Channel

Christian Rosenmund, Yael Stern-Bach, Charles F. Stevens *

The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

C. Rosenmund, Workgroup Cellular Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
Y. Stern-Bach, The Hebrew University-Hadassah Dental School, Department of Anatomy and Embryology, Post Office Box 12272, Jerusalem, Israel.
C. F. Stevens, Howard Hughes Medical Institute, The Salk Institute, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed. E-mail: cfs{at}salk.edu

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K. S. Jones, H. M. A. VanDongen, and A. M. J. VanDongen (2002)
J. Neurosci. 22, 2044-2053
   Abstract »    Full Text »    PDF »
Estimating Transmitter Release Rates from Postsynaptic Current Fluctuations.
E. Neher and T. Sakaba (2001)
J. Neurosci. 21, 9638-9654
   Abstract »    Full Text »    PDF »
Mathematical modelling of non-stationary fluctuation analysis for studying channel properties of synaptic AMPA receptors.
T. A Benke, A. Luthi, M. J Palmer, M. A Wikstrom, W. W Anderson, J. T R Isaac, and G. L Collingridge (2001)
J. Physiol. 537, 407-420
   Abstract »    Full Text »    PDF »
An Evaluation of Synapse Independence.
B. Barbour (2001)
J. Neurosci. 21, 7969-7984
   Abstract »    Full Text »    PDF »
Open probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancy.
D. D Mott, K. Erreger, T. G Banke, and S. F Traynelis (2001)
J. Physiol. 535, 427-443
   Abstract »    Full Text »    PDF »
Subunit Interactions and AMPA Receptor Desensitization.
A. Robert, S. N. Irizarry, T. E. Hughes, and J. R. Howe (2001)
J. Neurosci. 21, 5574-5586
   Abstract »    Full Text »    PDF »
Molecular Physiology of Kainate Receptors.
J. Lerma, A. V. Paternain, A. Rodriguez-Moreno, and J. C. Lopez-Garcia (2001)
Physiol Rev 81, 971-998
   Abstract »    Full Text »    PDF »
Identification of Amino Acid Residues in GluR1 Responsible for Ligand Binding and Desensitization.
T. G. Banke, J. R. Greenwood, J. K. Christensen, T. Liljefors, S. F. Traynelis, A. Schousboe, and D. S. Pickering (2001)
J. Neurosci. 21, 3052-3062
   Abstract »    Full Text »    PDF »
Theta-Frequency Facilitation of AMPA Receptor-Mediated Synaptic Currents in the Principal Cells of the Medial Septum.
J. N. Armstrong and B. A. MacVicar (2001)
J Neurophysiol 85, 1709-1718
   Abstract »    Full Text »    PDF »


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