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Science 29 May 1998:
Vol. 280. no. 5368, pp. 1455 - 1457
DOI: 10.1126/science.280.5368.1455
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Reports

Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton

Lisa J. Brunet, Jill A. McMahon, Andrew P. McMahon, Richard M. Harland *

Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs. In mice lacking Noggin, cartilage condensations initiated normally but developed hyperplasia, and initiation of joint development failed as measured by the expression of growth and differentiation factor-5. The maturation of cartilage and Hoxd expression were unaffected. Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues.

L. J. Brunet and R. M. Harland, Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720-3204, USA.
J. A. McMahon and A. P. McMahon, Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, MA 02138, USA.
*   To whom correspondence should be addressed. E-mail: harland{at}socrates.berkeley.edu

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   Abstract »    Full Text »
Regulation of Osteogenesis by Fetuin.
C. Binkert, M. Demetriou, B. Sukhu, M. Szweras, H. C. Tenenbaum, and J. W. Dennis (1999)
J. Biol. Chem. 274, 28514-28520
   Abstract »    Full Text »    PDF »
Type IIA Procollagen Containing the Cysteine-rich Amino Propeptide Is Deposited in the Extracellular Matrix of Prechondrogenic Tissue and Binds to TGF-beta 1 and BMP-2.
Y. Zhu, A. Oganesian, D. R. Keene, and L. J. Sandell (1999)
J. Cell Biol. 144, 1069-1080
   Abstract »    Full Text »    PDF »
Skeletal Bone Morphogenetic Proteins Suppress the Expression of Collagenase-3 by Rat Osteoblasts.
E. Gazzerro, S. Rydziel, and E. Canalis (1999)
Endocrinology 140, 562-567
   Abstract »    Full Text »
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling.
L. C. Murtaugh, J. H. Chyung, and A. B. Lassar (1999)
Genes & Dev. 13, 225-237
   Abstract »    Full Text »
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb.
R Merino, J Rodriguez-Leon, D Macias, Y Ganan, A. Economides, and J. Hurle (1999)
Development 126, 5515-5522
   Abstract »    PDF »
Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development.
M Weaver, J. Yingling, N. Dunn, S Bellusci, and B. Hogan (1999)
Development 126, 4005-4015
   Abstract »    PDF »
Control of digit formation by activin signalling.
R Merino, D Macias, Y Ganan, J Rodriguez-Leon, A. Economides, C Rodriguez-Esteban, J. Izpisua-Belmonte, and J. Hurle (1999)
Development 126, 2161-2170
   Abstract »    PDF »
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.
T. Yamaguchi, A Bradley, A. McMahon, and S Jones (1999)
Development 126, 1211-1223
   Abstract »    PDF »
Mechanisms of GDF-5 action during skeletal development.
P. Francis-West, A Abdelfattah, P Chen, C Allen, J Parish, R Ladher, S Allen, S MacPherson, F. Luyten, and C. Archer (1999)
Development 126, 1305-1315
   Abstract »    PDF »
BMPs negatively regulate structure and function of the limb apical ectodermal ridge.
S Pizette and L Niswander (1999)
Development 126, 883-894
   Abstract »    PDF »
Matrix GLA Protein Modulates Differentiation Induced by Bone Morphogenetic Protein-2 in C3H10T1/2 Cells.
K. Bostrom, D. Tsao, S. Shen, Y. Wang, and L. L. Demer (2001)
J. Biol. Chem. 276, 14044-14052
   Abstract »    Full Text »    PDF »
Indian hedgehog Is an Essential Component of Mechanotransduction Complex to Stimulate Chondrocyte Proliferation.
Q.-q. Wu, Y. Zhang, and Q. Chen (2001)
J. Biol. Chem. 276, 35290-35296
   Abstract »    Full Text »    PDF »
Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding.
J. Marcelino, C. M. Sciortino, M. F. Romero, L. M. Ulatowski, R. T. Ballock, A. N. Economides, P. M. Eimon, R. M. Harland, and M. L. Warman (2001)
PNAS 98, 11353-11358
   Abstract »    Full Text »    PDF »


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