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Science 29 May 1998:
Vol. 280. no. 5368, pp. 1378 - 1383
DOI: 10.1126/science.280.5368.1378
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Articles

Signals That Regulate Food Intake and Energy Homeostasis

Stephen C. Woods, * Randy J. Seeley, Daniel Porte Jr., Michael W. Schwartz

Feeding behavior is critical for survival. In addition to providing all of the body's macronutrients (carbohydrates, lipids, and proteins) and most micronutrients (minerals and vitamins), feeding behavior is a fundamental aspect of energy homeostasis, the process by which body fuel stored in the form of adipose tissue is held constant over long intervals. For this process to occur, the amount of energy consumed must match precisely the amount of energy expended. This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs.

S. C. Woods and R. J. Seeley are in the Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267-0559, USA. D. Porte Jr. and M. W. Schwartz are in the Department of Medicine, University of Washington and Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA.
*   To whom correspondence should be addressed. E-mail: swoods{at}uc.campus.mci.net

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