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Science 22 May 1998:
Vol. 280. no. 5367, pp. 1265 - 1267
DOI: 10.1126/science.280.5367.1265
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Requirement for gamma &dgr; T Cells in Allergic Airway Inflammation

Claudia Zuany-Amorim, * Claude Ruffié, Solomon Hailé, B. Boris Vargaftig, Pablo Pereira, dagger Marina Pretolani dagger ddagger

The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked gamma delta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to gamma delta T cell-deficient mice during the primary immunization. Thus, gamma delta T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.

C. Zuany-Amorim, C. Ruffié, B. B. Vargaftig, M. Pretolani, Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur/INSERM U485, Paris, France.
P. Pereira, Unité d'Immunobiologie, CNRS URA 1961, Institut Pasteur, Paris, France.
S. Hailé, Unité d'Histopathologie, Institut Pasteur, Paris, France.
*   Present address: Novartis Horsham Research Centre, Horsham, UK.

dagger    These authors contributed equally to this work.

ddagger    To whom correspondence should be addressed. E-mail: mpretol{at}pasteur.fr

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