Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Freiburg University

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 May 1998:
Vol. 280. no. 5366, pp. 1069 - 1072
DOI: 10.1126/science.280.5366.1069
Prev | Table of Contents | Next

Reports

Inhibitory Function of p21Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control

Ferdinando Di Cunto, Gabrielle Topley, Enzo Calautti, Jimmy Hsiao, Lydia Ong, Prem K. Seth, G. Paolo Dotto *

The cyclin-dependent kinase inhibitor p21Cip1/WAF1 has been implicated as an inducer of differentiation. However, although expression of p21 is increased in postmitotic cells immediately adjacent to the proliferative compartment, its expression is decreased in cells further along the differentiation program. Expression of the p21 protein was decreased in terminally differentiated primary keratinocytes of mice, and this occurred by a proteasome-dependent pathway. Forced expression of p21 in these cells inhibited the expression of markers of terminal differentiation at both the protein and messenger RNA levels. These inhibitory effects on differentiation were not observed with a carboxyl-terminal truncation mutant or with the unrelated cyclin-dependent kinase inhibitor p16INK4a, although all these molecules exerted similar inhibition of cell growth. These findings reveal an inhibitory role of p21 in the late stages of differentiation that does not result from the effects of p21 on the cell cycle.

F. Di Cunto, Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA, and Department of Biology, Genetics and Medical Chemistry, University of Torino, Via Santena 5 bis, Torino, Italy.
G. Topley, E. Calautti, J. Hsiao, L. Ong, G. P. Dotto, Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA.
P. K. Seth, Breast Cancer Section, Medicine Branch, National Cancer Institute, Building 10, Bethesda, MD 20892, USA.
*   To whom correspondence should be addressed. E-mail: Paolo_Dotto{at}cbrc.mgh.harvard.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Circadian Clock Component BMAL1 Is a Critical Regulator of p21WAF1/CIP1 Expression and Hepatocyte Proliferation.
A. Grechez-Cassiau, B. Rayet, F. Guillaumond, M. Teboul, and F. Delaunay (2008)
J. Biol. Chem. 283, 4535-4542
   Abstract »    Full Text »    PDF »
GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression.
M. F. Crook, M. Olive, H.-H. Xue, T. H. Langenickel, M. Boehm, W. J. Leonard, and E. G. Nabel (2008)
FASEB J 22, 225-235
   Abstract »    Full Text »    PDF »
Genetic Ablation of CCAAT/Enhancer Binding Protein {alpha} in Epidermis Reveals Its Role in Suppression of Epithelial Tumorigenesis.
K. D. Loomis, S. Zhu, K. Yoon, P. F. Johnson, and R. C. Smart (2007)
Cancer Res. 67, 6768-6776
   Abstract »    Full Text »    PDF »
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCK{alpha} kinases.
K. Lefort, A. Mandinova, P. Ostano, V. Kolev, V. Calpini, I. Kolfschoten, V. Devgan, J. Lieb, W. Raffoul, D. Hohl, et al. (2007)
Genes & Dev. 21, 562-577
   Abstract »    Full Text »    PDF »
p21WAF1/Cip1 Suppresses Keratinocyte Differentiation Independently of the Cell Cycle through Transcriptional Up-regulation of the IGF-I Gene.
V. Devgan, B.-C. Nguyen, H. Oh, and G. P. Dotto (2006)
J. Biol. Chem. 281, 30463-30470
   Abstract »    Full Text »    PDF »
Glucocorticoid-induced Tumor Necrosis Factor Receptor Is a p21Cip1/WAF1 Transcriptional Target Conferring Resistance of Keratinocytes to UV Light-induced Apoptosis.
J. Wang, V. Devgan, M. Corrado, N. S. Prabhu, W. S. El-Deiry, C. Riccardi, P. P. Pandolfi, C. Missero, and G. P. Dotto (2005)
J. Biol. Chem. 280, 37725-37731
   Abstract »    Full Text »    PDF »
p300 Regulates p63 Transcriptional Activity.
M. MacPartlin, S. Zeng, H. Lee, D. Stauffer, Y. Jin, M. Thayer, and H. Lu (2005)
J. Biol. Chem. 280, 30604-30610
   Abstract »    Full Text »    PDF »
Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression.
M. Grossi, A. Hiou-Feige, A. T. Di Vignano, E. Calautti, P. Ostano, S. Lee, G. Chiorino, and G. P. Dotto (2005)
PNAS 102, 11313-11318
   Abstract »    Full Text »    PDF »
Noncalcemic Actions of Vitamin D Receptor Ligands.
S. Nagpal, S. Na, and R. Rathnachalam (2005)
Endocr. Rev. 26, 662-687
   Abstract »    Full Text »    PDF »
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.
V. Devgan, C. Mammucari, S. E. Millar, C. Brisken, and G. P. Dotto (2005)
Genes & Dev. 19, 1485-1495
   Abstract »    Full Text »    PDF »
Role of Podocytes for Reversal of Glomerulosclerosis and Proteinuria in the Aging Kidney After Endothelin Inhibition.
J. Ortmann, K. Amann, R. P. Brandes, M. Kretzler, K. Munter, N. Parekh, T. Traupe, M. Lange, T. Lattmann, and M. Barton (2004)
Hypertension 44, 974-981
   Abstract »    Full Text »    PDF »
Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis.
S. Ruiz, M. Santos, C. Segrelles, H. Leis, J. L. Jorcano, A. Berns, J. M. Paramio, and M. Vooijs (2004)
Development 131, 2737-2748
   Abstract »    Full Text »    PDF »
UCN-01-Induced Cell Cycle Arrest Requires the Transcriptional Induction of p21waf1/cip1 by Activation of Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway.
M. M. Facchinetti, A. De Siervi, D. Toskos, and A. M. Senderowicz (2004)
Cancer Res. 64, 3629-3637
   Abstract »    Full Text »    PDF »
Immunohistochemical Expression of p27 and p21 in Canine Cutaneous Mast Cell Tumors and Histiocytomas.
H. Wu, T. Hayashi, and M. Inoue (2004)
Vet. Pathol. 41, 296-299
   Abstract »    Full Text »    PDF »
Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block.
V. Gottifredi, K. McKinney, M. V. Poyurovsky, and C. Prives (2004)
J. Biol. Chem. 279, 5802-5810
   Abstract »    Full Text »    PDF »
Efficient Down-Regulation of Cyclin A-Associated Activity and Expression in Suspended Primary Keratinocytes Requires p21Cip1.
P. Hauser, L. Ma, D. Agrawal, E. Haura, W. D. Cress, and W. J. Pledger (2004)
Mol. Cancer Res. 2, 96-104
   Abstract »    Full Text »    PDF »
Transcriptional Activation of p21waf1/cip1 by Alkylphospholipids: Role of the Mitogen-Activated Protein Kinase Pathway in the Transactivation of the Human p21waf1/cip1 Promoter by Sp1.
A. De Siervi, M. Marinissen, J. Diggs, X.-F. Wang, G. Pages, and A. Senderowicz (2004)
Cancer Res. 64, 743-750
   Abstract »    Full Text »    PDF »
S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes.
M. Sakaguchi, M. Miyazaki, M. Takaishi, Y. Sakaguchi, E. Makino, N. Kataoka, H. Yamada, M. Namba, and N.-h. Huh (2003)
J. Cell Biol. 163, 825-835
   Abstract »    Full Text »    PDF »
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.
C. Yu, M. Rahmani, D. Conrad, M. Subler, P. Dent, and S. Grant (2003)
Blood 102, 3765-3774
   Abstract »    Full Text »    PDF »
The Cyclin-dependent Kinase Inhibitor p21CIP/WAF Is a Positive Regulator of Insulin-like Growth Factor I-induced Cell Proliferation in MCF-7 Human Breast Cancer Cells.
J. Dupont, M. Karas, and D. LeRoith (2003)
J. Biol. Chem. 278, 37256-37264
   Abstract »    Full Text »    PDF »
E2F Modulates Keratinocyte Squamous Differentiation: IMPLICATIONS FOR E2F INHIBITION IN SQUAMOUS CELL CARCINOMA.
C. F. Wong, L. M. Barnes, A. L. Dahler, L. Smith, M. M. Serewko-Auret, C. Popa, I. Abdul-Jabbar, and N. A. Saunders (2003)
J. Biol. Chem. 278, 28516-28522
   Abstract »    Full Text »    PDF »
Expression of Cyclin-Dependent Kinase 6, but not Cyclin-Dependent Kinase 4, Alters Morphology of Cultured Mouse Astrocytes.
K. K. Ericson, D. Krull, P. Slomiany, and M. J. Grossel (2003)
Mol. Cancer Res. 1, 654-664
   Abstract »    Full Text »    PDF »
Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.
S. Ruiz, C. Segrelles, A. Bravo, M. Santos, P. Perez, H. Leis, J. L. Jorcano, and J. M. Paramio (2003)
Development 130, 2341-2353
   Abstract »    Full Text »    PDF »
Parathyroid cell growth in patients with advanced secondary hyperparathyroidism: vitamin D receptor and cyclin-dependent kinase inhibitors, p21 and p27.
M. Tokumoto, K. Tsuruya, K. Fukuda, H. Kanai, S. Kuroki, H. Hirakata, and M. Iida (2003)
Nephrol. Dial. Transplant. 18, iii9-12
   Abstract »    Full Text »    PDF »
Oxygen Sensing by Primary Cardiac Fibroblasts: A Key Role of p21Waf1/Cip1/Sdi1.
S. Roy, S. Khanna, A. A. Bickerstaff, S. V. Subramanian, M. Atalay, M. Bierl, S. Pendyala, D. Levy, N. Sharma, M. Venojarvi, et al. (2003)
Circ. Res. 92, 264-271
   Abstract »    Full Text »    PDF »
NF-{kappa}B-Mediated Induction of p21Cip1/Waf1 by Tumor Necrosis Factor {alpha} Induces Growth Arrest and Cytoprotection in Normal Human Keratinocytes.
J. R. Basile, A. Eichten, V. Zacny, and K. Munger (2003)
Mol. Cancer Res. 1, 262-270
   Abstract »    Full Text »    PDF »
p21CIP1 Controls Proliferating Cell Nuclear Antigen Level in Adult Cardiomyocytes.
F. B. Engel, L. Hauck, M. Boehm, E. G. Nabel, R. Dietz, and R. von Harsdorf (2003)
Mol. Cell. Biol. 23, 555-565
   Abstract »    Full Text »    PDF »
The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus.
A. E. Vernon, C. Devine, and A. Philpott (2003)
Development 130, 85-92
   Abstract »    Full Text »    PDF »
P21WAF1 CONTROL OF EPITHELIAL CELL CYCLE AND CELL FATE.
W. C. Weinberg and M. F. Denning (2002)
Crit. Rev. Oral. Biol. Med. 13, 453-464
   Abstract »    Full Text »    PDF »
Identification of differentially expressed genes in subcutaneous adipose tissue from subjects with familial combined hyperlipidemia.
P. M. H. Eurlings, C. J. H. van der Kallen, J. M. W. Geurts, P. Kouwenberg, W. D. Boeckx, and T. W. A. de Bruin (2002)
J. Lipid Res. 43, 930-935
   Abstract »    Full Text »    PDF »
Molecular Signaling in Bioengineered Tissue Microenvironments.
D. P. BOTTARO, A. LIEBMANN-VINSON, and M. A. HEIDARAN (2002)
Ann. N.Y. Acad. Sci. 961, 143-153
   Abstract »    Full Text »    PDF »
Negative regulation of cell growth and differentiation by TSG101 through association with p21Cip1/WAF1.
H. Oh, C. Mammucari, A. Nenci, S. Cabodi, S. N. Cohen, and G. P. Dotto (2002)
PNAS 99, 5430-5435
   Abstract »    Full Text »    PDF »
Enhanced Growth Inhibition by Combination Differentiation Therapy with Ligands of Peroxisome Proliferator-activated Receptor-{gamma} and Inhibitors of Histone Deacetylase in Adenocarcinoma of the Lung.
T.-H. Chang and E. Szabo (2002)
Clin. Cancer Res. 8, 1206-1212
   Abstract »    Full Text »    PDF »
Perifosine, a Novel Alkylphospholipid, Induces p21WAF1 Expression in Squamous Carcinoma Cells through a p53-independent Pathway, Leading to Loss in Cyclin-dependent Kinase Activity and Cell Cycle Arrest.
V. Patel, T. Lahusen, T. Sy, E. A. Sausville, J. S. Gutkind, and A. M. Senderowicz (2002)
Cancer Res. 62, 1401-1409
   Abstract »    Full Text »    PDF »
Increased p50/p50 NF-{kappa}B Activation in Human Papillomavirus Type 6- or Type 11-Induced Laryngeal Papilloma Tissue.
I. Vancurova, R. Wu, V. Miskolci, and S. Sun (2002)
J. Virol. 76, 1533-1536
   Abstract »    Full Text »    PDF »
Human Papillomavirus Type 16 E7 Maintains Elevated Levels of the cdc25A Tyrosine Phosphatase during Deregulation of Cell Cycle Arrest.
D. X. Nguyen, T. F. Westbrook, and D. J. McCance (2002)
J. Virol. 76, 619-632
   Abstract »    Full Text »    PDF »
Regulation of Cyclin D1 and p16INK4A Is Critical for Growth Arrest during Mammary Involution.
M. Gadd, C. Pisc, J. Branda, V. Ionescu-Tiba, Z. Nikolic, C. Yang, T. Wang, G. M. Shackleford, R. D. Cardiff, and E. V. Schmidt (2001)
Cancer Res. 61, 8811-8819
   Abstract »    Full Text »    PDF »
The ink4a/arf Tumor Suppressors Cooperate with p21cip1/waf in the Processes of Mouse Epidermal Differentiation, Senescence, and Carcinogenesis.
J. M. Paramio, C. Segrelles, S. Ruiz, J. Martin-Caballero, A. Page, J. Martinez, M. Serrano, and J. L. Jorcano (2001)
J. Biol. Chem. 276, 44203-44211
   Abstract »    Full Text »    PDF »
Patterns of p21waf1/cip1 expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas.
M J Schwerer, A Sailer, K Kraft, K Baczako, and H Maier (2001)
J. Clin. Pathol. 54, 871-876
   Abstract »    Full Text »    PDF »
ER{beta} Inhibits Proliferation and Invasion of Breast Cancer Cells.
G. Lazennec, D. Bresson, A. Lucas, C. Chauveau, and F. Vignon (2001)
Endocrinology 142, 4120-4130
   Abstract »    Full Text »    PDF »
Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.
L. J. Wainwright, A. Lasorella, and A. Iavarone (2001)
PNAS 98, 9396-9400
   Abstract »    Full Text »    PDF »
p21cip1 Degradation in Differentiated Keratinocytes Is Abrogated by Costabilization with Cyclin E Induced by Human Papillomavirus E7.
F. Noya, W.-M. Chien, T. R. Broker, and L. T. Chow (2001)
J. Virol. 75, 6121-6134
   Abstract »    Full Text »    PDF »
Interferon-gamma downregulates ion transport in murine small intestine cultured in vitro.
D. Yoo, W. Lo, S. Goodman, W. Ali, C. Semrad, and M. Field (2000)
Am J Physiol Gastrointest Liver Physiol 279, G1323-G1332
   Abstract »    Full Text »    PDF »
Protein Kinase C Signaling Mediates a Program of Cell Cycle Withdrawal in the Intestinal Epithelium.
M. R. Frey, J. A. Clark, O. Leontieva, J. M. Uronis, A. R. Black, and J. D. Black (2000)
J. Cell Biol. 151, 763-778
   Abstract »    Full Text »    PDF »
Id Proteins Are Dynamically Expressed in Normal Epidermis and Dysregulated in Squamous Cell Carcinoma.
K. Langlands, G. A. Down, and T. Kealey (2000)
Cancer Res. 60, 5929-5933
   Abstract »    Full Text »
p27Kip1 is an inducer of intestinal epithelial cell differentiation.
A. Quaroni, J. Q. Tian, P. Seth, and C. Ap Rhys (2000)
Am J Physiol Cell Physiol 279, C1045-C1057
   Abstract »    Full Text »    PDF »
C/EBPalpha Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription.
B. A. Slomiany, K. L. D'Arigo, M. M. Kelly, and D. T. Kurtz (2000)
Mol. Cell. Biol. 20, 5986-5997
   Abstract »    Full Text »
Nuclear Factor {{kappa}}B Subunits Induce Epithelial Cell Growth Arrest.
C. S. Seitz, H. Deng, K. Hinata, Q. Lin, and P. A. Khavari (2000)
Cancer Res. 60, 4085-4092
   Abstract »    Full Text »
Melanin Accumulation Accelerates Melanocyte Senescence by a Mechanism Involving p16INK4a/CDK4/pRB and E2F1.
D. BANDYOPADHYAY and E. E. MEDRANO (2000)
Ann. N.Y. Acad. Sci. 908, 71-84
   Abstract »    Full Text »    PDF »
Downregulation of 14-3-3{sigma} Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes.
E. Dellambra, O. Golisano, S. Bondanza, E. Siviero, P. Lacal, M. Molinari, S. D'Atri, and M. De Luca (2000)
J. Cell Biol. 149, 1117-1130
   Abstract »    Full Text »    PDF »
Induction of Neuronal Differentiation by p73 in a Neuroblastoma Cell Line.
V. De Laurenzi, G. Raschella, D. Barcaroli, M. Annicchiarico-Petruzzelli, M. Ranalli, M. V. Catani, B. Tanno, A. Costanzo, M. Levrero, and G. Melino (2000)
J. Biol. Chem. 275, 15226-15231
   Abstract »    Full Text »    PDF »
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases.
B.-D. Chang, K. Watanabe, E. V. Broude, J. Fang, J. C. Poole, T. V. Kalinichenko, and I. B. Roninson (2000)
PNAS 97, 4291-4296
   Abstract »    Full Text »    PDF »
Hematopoietic Stem Cell Quiescence Maintained by p21cip1/waf1.
T. Cheng, N. Rodrigues, H. Shen, Y. Yang, D. Dombkowski, M. Sykes, and D. T. Scadden (2000)
Science 287, 1804-1808
   Abstract »    Full Text »
Expression of Human Papilloma Virus E7 Protein Causes Apoptosis and Inhibits DNA Synthesis in Primary Hepatocytes via Increased Expression of p21Cip-1/WAF1/MDA6.
J.-S. Park, S. Boyer, K. Mitchell, D. Gilfor, M. Birrer, G. Darlington, W. El Deiry, G. L. Firestone, K. Munger, V. Band, et al. (2000)
J. Biol. Chem. 275, 18-28
   Abstract »    Full Text »    PDF »
Induction of Differentiation-dependent Apoptosis in Human Esophageal Squamous Cell Carcinoma by Adenovirus-mediated p21sdi1 Gene Transfer.
Y. Kadowaki, T. Fujiwara, T. Fukazawa, J. Shao, T. Yasuda, T. Itoshima, S. Kagawa, L. G. Hudson, J. A. Roth, and N. Tanaka (1999)
Clin. Cancer Res. 5, 4233-4241
   Abstract »    Full Text »    PDF »
Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest.
H. Fan and P. A. Khavari (1999)
J. Cell Biol. 147, 71-76
   Abstract »    Full Text »    PDF »
C/EBPbeta Modulates the Early Events of Keratinocyte Differentiation Involving Growth Arrest and Keratin 1 and Keratin 10 Expression.
S. Zhu, H.-S. Oh, M. Shim, E. Sterneck, P. F. Johnson, and R. C. Smart (1999)
Mol. Cell. Biol. 19, 7181-7190
   Abstract »    Full Text »    PDF »
E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation.
S. P. Persengiev, I. I. Kondova, and D. L. Kilpatrick (1999)
Mol. Cell. Biol. 19, 6048-6056
   Abstract »    Full Text »    PDF »
Elevated Cyclin E Levels, Inactive Retinoblastoma Protein, and Suppression of the p27KIP1 Inhibitor Characterize Early Development of Promyeloid Cells into Macrophages.
Q. Liu, R. W. VanHoy, J. H. Zhou, R. Dantzer, G. G. Freund, and K. W. Kelley (1999)
Mol. Cell. Biol. 19, 6229-6239
   Abstract »    Full Text »    PDF »
Apoptosis in Proliferating, Senescent, and Immortalized Keratinocytes.
V. Chaturvedi, J.-Z. Qin, M. F. Denning, D. Choubey, M. O. Diaz, and B. J. Nickoloff (1999)
J. Biol. Chem. 274, 23358-23367
   Abstract »    Full Text »    PDF »
p21WAF1/Cip1 functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.
G. I. Topley, R. Okuyama, J. G. Gonzales, C. Conti, and G. P. Dotto (1999)
PNAS 96, 9089-9094
   Abstract »    Full Text »    PDF »
Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase.
S. Rao, D. C. Porter, X. Chen, T. Herliczek, M. Lowe, and K. Keyomarsi (1999)
PNAS 96, 7797-7802
   Abstract »    Full Text »    PDF »
Cyclin D1 Overexpression in Mouse Epidermis Increases Cyclin-dependent Kinase Activity and Cell Proliferation in Vivo but Does Not Affect Skin Tumor Development.
M. L. Rodriguez-Puebla, M. LaCava, and C. J. Conti (1999)
Cell Growth Differ. 10, 467-472
   Abstract »    Full Text »
Voltage-Activated K+ Channels and Membrane Depolarization Regulate Accumulation of the Cyclin-Dependent Kinase Inhibitors p27Kip1 and p21CIP1 in Glial Progenitor Cells.
C. A. Ghiani, X. Yuan, A. M. Eisen, P. L. Knutson, R. A. DePinho, C. J. McBain, and V. Gallo (1999)
J. Neurosci. 19, 5380-5392
   Abstract »    Full Text »    PDF »
Expression of p21Cip1/Waf1/Sdi1 and p27Kip1 Cyclin-Dependent Kinase Inhibitors During Human Hematopoiesis.
T. Taniguchi, H. Endo, N. Chikatsu, K. Uchimaru, S. Asano, T. Fujita, T. Nakahata, and T. Motokura (1999)
Blood 93, 4167-4178
   Abstract »    Full Text »    PDF »
Hypothesis: Progesterone Primes Breast Cancer Cells for Cross-Talk with Proliferative or Antiproliferative Signals.
C. A. Lange, J. K. Richer, and K. B. Horwitz (1999)
Mol. Endocrinol. 13, 829-836
   Full Text »
Neonatal Estrogen Exposure Alters the Transforming Growth Factor-{beta} Signaling System in the Developing Rat Prostate and Blocks the Transient p21cip1/waf1 Expression Associated with Epithelial Differentiation.
W. Y. Chang, L. Birch, C. Woodham, L. I. Gold, and G. S. Prins (1999)
Endocrinology 140, 2801-2813
   Abstract »    Full Text »
1,25-Dihydroxycholecalciferol (1,25-D3) Inhibits the Growth of Squamous Cell Carcinoma and Down-Modulates p21Waf1/Cip1 in Vitro and in Vivo.
P. A. Hershberger, R. A. Modzelewski, Z. R. Shurin, R. M. Rueger, D. L. Trump, and C. S. Johnson (1999)
Cancer Res. 59, 2644-2649
   Abstract »    Full Text »    PDF »
Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation.
J. Q. Tian and A. Quaroni (1999)
Am J Physiol Cell Physiol 276, C1245-C1258
   Abstract »    Full Text »    PDF »
Genetic Deletion of p21WAF1 Enhances Papilloma Formation but not Malignant Conversion in Experimental Mouse Skin Carcinogenesis.
W. C. Weinberg, E. Fernandez-Salas, D. L. Morgan, A. Shalizi, E. Mirosh, E. Stanulis, C. Deng, H. Hennings, and S. H. Yuspa (1999)
Cancer Res. 59, 2050-2054
   Abstract »    Full Text »    PDF »
Subcellular and Cell-Cycle Expression Profiles of CDK-Inhibitors in Normal Differentiating Myeloid Cells.
B. Yaroslavskiy, S. Watkins, A.D. Donnenberg, T.J. Patton, and R.A. Steinman (1999)
Blood 93, 2907-2917
   Abstract »    Full Text »    PDF »
Induced Differentiation of U937 Cells by 1,25-dihydroxyvitamin D3 Involves Cell Cycle Arrest in G1 That Is Preceded by a Transient Proliferative Burst and an Increase in Cyclin Expression.
N. Y. Rots, A. Iavarone, V. Bromleigh, and L. P. Freedman (1999)
Blood 93, 2721-2729
   Abstract »    Full Text »    PDF »
Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts.
G. H. Stein, L. F. Drullinger, A. Soulard, and V. Dulic (1999)
Mol. Cell. Biol. 19, 2109-2117
   Abstract »    Full Text »    PDF »
Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth.
M. K. Abe, W.-L. Kuo, M. B. Hershenson, and M. R. Rosner (1999)
Mol. Cell. Biol. 19, 1301-1312
   Abstract »    Full Text »    PDF »
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti.
P Chen and N Segil (1999)
Development 126, 1581-1590
   Abstract »    PDF »
Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer. POTENTIATION OF MITOGEN-ACTIVATED PROTEIN KINASE PATHWAYS.
C. A. Lange, J. K. Richer, T. Shen, and K. B. Horwitz (1998)
J. Biol. Chem. 273, 31308-31316
   Abstract »    Full Text »    PDF »
Down-Regulation of p27 Is Associated with Development of Colorectal Adenocarcinoma Metastases.
G. V. Thomas, K. Szigeti, M. Murphy, G. Draetta, M. Pagano, and M. Loda (1998)
Am. J. Pathol. 153, 681-687
   Abstract »    Full Text »    PDF »
Functional Interaction of STAT3 Transcription Factor with the Cell Cycle Inhibitor p21WAF1/CIP1/SDI1.
O. Coqueret and H. Gascan (2000)
J. Biol. Chem. 275, 18794-18800
   Abstract »    Full Text »    PDF »
Rapid Induction of Histone Hyperacetylation and Cellular Differentiation in Human Breast Tumor Cell Lines following Degradation of Histone Deacetylase-1.
Q. Zhou, Z. K. Melkoumian, A. Lucktong, M. Moniwa, J. R. Davie, and J. S. Strobl (2000)
J. Biol. Chem. 275, 35256-35263
   Abstract »    Full Text »    PDF »
Apoptosis Signal-regulating Kinase 1 (ASK1) Is an Intracellular Inducer of Keratinocyte Differentiation.
K. Sayama, Y. Hanakawa, Y. Shirakata, K. Yamasaki, Y. Sawada, L. Sun, K. Yamanishi, H. Ichijo, and K. Hashimoto (2001)
J. Biol. Chem. 276, 999-1004
   Abstract »    Full Text »    PDF »
p21Cip-1/SDI-1/WAF-1 Gene Is Involved in Chondrogenic Differentiation of ATDC5 Cells in Vitro.
Y. Negishi, N. Ui, M. Nakajima, K. Kawashima, K. Maruyama, T. Takizawa, and H. Endo (2001)
J. Biol. Chem. 276, 33249-33256
   Abstract »    Full Text »    PDF »
Negative regulation of cell growth and differentiation by TSG101 through association with p21Cip1/WAF1.
H. Oh, C. Mammucari, A. Nenci, S. Cabodi, S. N. Cohen, and G. P. Dotto (2002)
PNAS 99, 5430-5435
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT