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Science 24 April 1998:
Vol. 280. no. 5363, pp. 596 - 599
DOI: 10.1126/science.280.5363.596
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Reports

Functional Interaction of an Axin Homolog, Conductin, with beta -Catenin, APC, and GSK3beta

Jürgen Behrens, Boris-Alexander Jerchow, Martin Würtele, Jan Grimm, Christian Asbrand, Ralph Wirtz, Michael Kühl, Doris Wedlich, Walter Birchmeier *

Control of stability of beta -catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta -catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta -catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta -catenin. Fragments of APC that contained a conductin-binding domain also blocked beta -catenin degradation. Thus, conductin is a component of the multiprotein complex that directs beta -catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.

J. Behrens, B.-A. Jerchow, M. Würtele, J. Grimm, C. Asbrand, R. Wirtz, W. Birchmeier, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13122 Berlin, Germany.
M. Kühl and D. Wedlich, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
*   To whom correspondence should be addressed. E-mail: wbirch{at}mdc-berlin.de

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   Abstract »    Full Text »    PDF »
Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer.
K. Teye, M. Tsuneoka, N. Arima, Y. Koda, Y. Nakamura, Y. Ueta, K. Shirouzu, and H. Kimura (2004)
Am. J. Pathol. 164, 205-216
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Activation of the Canonical {beta}-Catenin Pathway by Histamine.
S. H. Diks, J. C. Hardwick, R. M. Diab, M. M. van Santen, H. H. Versteeg, S. J. H. van Deventer, D. J. Richel, and M. P. Peppelenbosch (2003)
J. Biol. Chem. 278, 52491-52496
   Abstract »    Full Text »    PDF »
TIP49 Regulates {beta}-Catenin-Mediated Neoplastic Transformation and T-Cell Factor Target Gene Induction via Effects on Chromatin Remodeling.
Y. Feng, N. Lee, and E. R. Fearon (2003)
Cancer Res. 63, 8726-8734
   Abstract »    Full Text »    PDF »
Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear {beta} catenin accumulation and k-ras gene mutation.
K Yamazaki, K Hanami, T Nagao, A Asoh, I Sugano, and Y Ishida (2003)
Mol. Pathol. 56, 336-341
   Abstract »    Full Text »    PDF »
Crystal structure of a {beta}-catenin/Axin complex suggests a mechanism for the {beta}-catenin destruction complex.
Y. Xing, W. K. Clements, D. Kimelman, and W. Xu (2003)
Genes & Dev. 17, 2753-2764
   Abstract »    Full Text »    PDF »
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse.
N. F. Paoni, M. W. Feldman, L. S. Gutierrez, V. A. Ploplis, and F. J. Castellino (2003)
Physiol Genomics 15, 228-235
   Abstract »    Full Text »    PDF »
Eradication of pathogenic {beta}-catenin by Skp1/Cullin/F box ubiquitination machinery.
Y. Su, S. Ishikawa, M. Kojima, and B. Liu (2003)
PNAS 100, 12729-12734
   Abstract »    Full Text »    PDF »
Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation.
W. Luo, W. W. Ng, L.-H. Jin, Z. Ye, J. Han, and S.-C. Lin (2003)
J. Biol. Chem. 278, 37451-37458
   Abstract »    Full Text »    PDF »
Mild Heat and Proteotoxic Stress Promote Unique Subcellular Trafficking and Nucleolar Accumulation of RGS6 and Other RGS Proteins: ROLE OF THE RGS DOMAIN IN STRESS-INDUCED TRAFFICKING OF RGS PROTEINS.
T. K. Chatterjee and R. A. Fisher (2003)
J. Biol. Chem. 278, 30272-30282
   Abstract »    Full Text »    PDF »
Clusterin as a biomarker in murine and human intestinal neoplasia.
X. Chen, R. B. Halberg, W. M. Ehrhardt, J. Torrealba, and W. F. Dove (2003)
PNAS 100, 9530-9535
   Abstract »    Full Text »    PDF »
{beta}-Catenin Regulation during the Cell Cycle: Implications in G2/M and Apoptosis.
D. Olmeda, S. Castel, S. Vilaro, and A. Cano (2003)
Mol. Biol. Cell 14, 2844-2860
   Abstract »    Full Text »    PDF »
CK2 Phosphorylation of the Armadillo Repeat Region of {beta}-Catenin Potentiates Wnt Signaling.
D. H. Song, I. Dominguez, J. Mizuno, M. Kaut, S. C. Mohr, and D. C. Seldin (2003)
J. Biol. Chem. 278, 24018-24025
   Abstract »    Full Text »    PDF »
Pre-cancerous lesions for colorectal cancers in rodents: a new concept.
Y. Yamada and H. Mori (2003)
Carcinogenesis 24, 1015-1019
   Abstract »    Full Text »    PDF »
HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells.
T. Valenta, J. Lukas, and V. Korinek (2003)
Nucleic Acids Res. 31, 2369-2380
   Abstract »    Full Text »    PDF »
Casein Kinase Iepsilon Enhances the Binding of Dvl-1 to Frat-1 and Is Essential for Wnt-3a-induced Accumulation of beta -Catenin.
S.-i. Hino, T. Michiue, M. Asashima, and A. Kikuchi (2003)
J. Biol. Chem. 278, 14066-14073
   Abstract »    Full Text »    PDF »
Germline mutations in the TGF-{beta} and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype.
L Lipton, O M Sieber, H J W Thomas, S V Hodgson, I P M Tomlinson, and K Woodford-Richens (2003)
J. Med. Genet. 40, e35-35
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Protein kinase CKII regulates the interaction of {beta}-catenin with {alpha}-catenin and its protein stability.
S. Bek and R. Kemler (2003)
J. Cell Sci. 115, 4743-4753
   Abstract »    Full Text »    PDF »
Signaling of Rat Frizzled-2 Through Phosphodiesterase and Cyclic GMP.
A. Ahumada, D. C. Slusarski, X. Liu, R. T. Moon, C. C. Malbon, and H.-y. Wang (2002)
Science 298, 2006-2010
   Abstract »    Full Text »    PDF »


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