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Science 24 April 1998:
Vol. 280. no. 5363, pp. 547 - 553
DOI: 10.1126/science.280.5363.547
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Review

Structure and Function in the Nucleus

Angus I. Lamond, * William C. Earnshaw

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

A. I. Lamond is in the Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, UK. W. C. Earnshaw is in the Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK.
*   To whom correspondence should be addressed. E-mail: a.i.lamond{at}dundee.ac.uk

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S. Garagna, M. Zuccotti, A. Thornhill, R. Fernandez-Donoso, S. Berrios, E. Capanna, and C. A. Redi (2002)
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   Abstract »    Full Text »    PDF »
Distinct changes in intranuclear lamin A/C organization during myoblast differentiation.
Bh. Muralikrishna, J. Dhawan, N. Rangaraj, and V. K. Parnaik (2002)
J. Cell Sci. 114, 4001-4011
   Abstract »    Full Text »    PDF »
Nuclear domains.
D. L. Spector (2002)
J. Cell Sci. 114, 2891-2893
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Modifiers of Terminal Deficiency-Associated Position Effect Variegation in Drosophila.
K. M. Donaldson, A. Lui, and G. H. Karpen (2002)
Genetics 160, 995-1009
   Abstract »    Full Text »    PDF »
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing.
P. Sacco-Bubulya and D. L. Spector (2002)
J. Cell Biol. 156, 425-436
   Abstract »    Full Text »    PDF »
The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells.
D. S. Dimitrova and R. Berezney (2002)
J. Cell Sci. 115, 4037-4051
   Abstract »    Full Text »    PDF »
Nuclear organization in differentiating oligodendrocytes.
J. A. Nielsen, L. D. Hudson, and R. C. Armstrong (2002)
J. Cell Sci. 115, 4071-4079
   Abstract »    Full Text »    PDF »
Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains.
K. S. Harrington, A. Javed, H. Drissi, S. McNeil, J. B. Lian, J. L. Stein, A. J. van Wijnen, Y.-L. Wang, and G. S. Stein (2002)
J. Cell Sci. 115, 4167-4176
   Abstract »    Full Text »    PDF »


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