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Science 17 April 1998:
Vol. 280. no. 5362, pp. 438 - 440
DOI: 10.1126/science.280.5362.438
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Reports

Autoinducer of Virulence As a Target for Vaccine and Therapy Against Staphylococcus aureus

Naomi Balaban, * Tzipora Goldkorn, Rachael T. Nhan, Luong B. Dang, Steven Scott, Rose M. Ridgley, Avraham Rasooly, Susan C. Wright, James W. Larrick, Reuven Rasooly, James R. Carlson

Staphylococcus aureus causes pathologies ranging from minor skin infections to life-threatening diseases. Pathogenic effects are largely due to production of bacterial toxin, which is regulated by an RNA molecule, RNAIII. The S. aureus protein called RAP (RNAIII activating protein) activates RNAIII, and a peptide called RIP (RNAIII inhibiting peptide), produced by a nonpathogenic bacteria, inhibits RNAIII. Mice vaccinated with RAP or treated with purified or synthetic RIP were protected from S. aureus pathology. Thus, these two molecules may provide useful approaches for the prevention and treatment of diseases caused by S. aureus.

N. Balaban, R. T. Nhan, S. Scott, R. M. Ridgley, R. Rasooly, J. R. Carlson, Department of Medical Pathology, University of California, Davis, CA 95616, USA.
T. Goldkorn and L. B. Dang, Department of Internal Medicine, University of California, Davis Medical Center, Davis, CA 95616, USA.
A. Rasooly, Department of Microbiology, University of Maryland, College Park, MD 20742, USA.
S. C. Wright and J. W. Larrick, Palo Alto Research Institute of Molecular Medicine, Mountain View, CA 94043, USA.
*   To whom correspondence should be addressed. E-mail: nbalaban{at}ucdavis.edu

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