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Science 10 April 1998:
Vol. 280. no. 5361, pp. 295 - 298
DOI: 10.1126/science.280.5361.295
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Reports

The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm

David G. Davies, Matthew R. Parsek, James P. Pearson, Barbara H. Iglewski, J. W. Costerton, E. P. Greenberg *

Bacteria in nature often exist as sessile communities called biofilms. These communities develop structures that are morphologically and physiologically differentiated from free-living bacteria. A cell-to-cell signal is involved in the development of Pseudomonas aeruginosa biofilms. A specific signaling mutant, a lasI mutant, forms flat, undifferentiated biofilms that unlike wild-type biofilms are sensitive to the biocide sodium dodecyl sulfate. Mutant biofilms appeared normal when grown in the presence of a synthetic signal molecule. The involvement of an intercellular signal molecule in the development of P. aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aeruginosa biofilms are a persistent problem.

D. G. Davies and J. W. Costerton, Center for Biofilm Engineering, Montana State University, Bozeman, MT 59717-3980, USA.
M. R. Parsek and E. P. Greenberg, Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
J. P. Pearson and B. H. Iglewski, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.
*   To whom correspondence should be addressed. E-mail: epgreen{at}blue.weeg.uiowa.edu

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V. V. Kravchenko, G. F. Kaufmann, J. C. Mathison, D. A. Scott, A. Z. Katz, M. R. Wood, A. P. Brogan, M. Lehmann, J. M. Mee, K. Iwata, et al. (2006)
J. Biol. Chem. 281, 28822-28830
   Abstract »    Full Text »    PDF »
LuxS Involvement in the Regulation of Genes Coding for Hemin and Iron Acquisition Systems in Porphyromonas gingivalis.
C. E. James, Y. Hasegawa, Y. Park, V. Yeung, G. D. Tribble, M. Kuboniwa, D. R. Demuth, and R. J. Lamont (2006)
Infect. Immun. 74, 3834-3844
   Abstract »    Full Text »    PDF »
Bundle-Forming Pili and EspA Are Involved in Biofilm Formation by Enteropathogenic Escherichia coli.
C. G. Moreira, K. Palmer, M. Whiteley, M. P. Sircili, L. R. Trabulsi, A. F. P. Castro, and V. Sperandio (2006)
J. Bacteriol. 188, 3952-3961
   Abstract »    Full Text »    PDF »
Quorum-Sensing Antagonistic Activities of Azithromycin in Pseudomonas aeruginosa PAO1: a Global Approach..
Y. Nalca, L. Jansch, F. Bredenbruch, R. Geffers, J. Buer, and S. Haussler (2006)
Antimicrob. Agents Chemother. 50, 1680-1688
   Abstract »    Full Text »    PDF »
A Distinct QscR Regulon in the Pseudomonas aeruginosa Quorum-Sensing Circuit.
Y. Lequette, J.-H. Lee, F. Ledgham, A. Lazdunski, and E. P. Greenberg (2006)
J. Bacteriol. 188, 3365-3370
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Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii.
M. D. Koutsoudis, D. Tsaltas, T. D. Minogue, and S. B. von Bodman (2006)
PNAS 103, 5983-5988
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YliH (BssR) and YceP (BssS) Regulate Escherichia coli K-12 Biofilm Formation by Influencing Cell Signaling.
J. Domka, J. Lee, and T. K. Wood (2006)
Appl. Envir. Microbiol. 72, 2449-2459
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Characterization of Biofilm Formation by Clinically Relevant Serotypes of Group A Streptococci.
C. Lembke, A. Podbielski, C. Hidalgo-Grass, L. Jonas, E. Hanski, and B. Kreikemeyer (2006)
Appl. Envir. Microbiol. 72, 2864-2875
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Dual Control of Quorum Sensing by Two TraM-Type Antiactivators in Agrobacterium tumefaciens Octopine Strain A6..
C. Wang, H.-B. Zhang, G. Chen, L. Chen, and L.-H. Zhang (2006)
J. Bacteriol. 188, 2435-2445
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A Database of Bacterial Lipoproteins (DOLOP) with Functional Assignments to Predicted Lipoproteins..
M. M. Babu, M. L. Priya, A. T. Selvan, M. Madera, J. Gough, L. Aravind, and K. Sankaran (2006)
J. Bacteriol. 188, 2761-2773
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The ppuI-rsaL-ppuR Quorum-Sensing System Regulates Biofilm Formation of Pseudomonas putida PCL1445 by Controlling Biosynthesis of the Cyclic Lipopeptides Putisolvins I and II..
J.-F. Dubern, B. J. J. Lugtenberg, and G. V. Bloemberg (2006)
J. Bacteriol. 188, 2898-2906
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Quorum sensing inhibitors: a bargain of effects..
T. B. Rasmussen and M. Givskov (2006)
Microbiology 152, 895-904
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Chelator-Induced Dispersal and Killing of Pseudomonas aeruginosa Cells in a Biofilm..
E. Banin, K. M. Brady, and E. P. Greenberg (2006)
Appl. Envir. Microbiol. 72, 2064-2069
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Identification of QuiP, the Product of Gene PA1032, as the Second Acyl-Homoserine Lactone Acylase of Pseudomonas aeruginosa PAO1.
J. J. Huang, A. Petersen, M. Whiteley, and J. R. Leadbetter (2006)
Appl. Envir. Microbiol. 72, 1190-1197
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Enhanced Benzaldehyde Tolerance in Zymomonas mobilis Biofilms and the Potential of Biofilm Applications in Fine-Chemical Production.
X. Z. Li, J. S. Webb, S. Kjelleberg, and B. Rosche (2006)
Appl. Envir. Microbiol. 72, 1639-1644
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