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Science 10 April 1998:
Vol. 280. no. 5361, pp. 243 - 248
DOI: 10.1126/science.280.5361.243
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Articles

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

Luk Van Parijs, * Abul K. Abbas

The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.

The authors are in the Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
*   Present address: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Responding naive T cells differ in their sensitivity to Fas engagement: early death of many T cells is compensated by costimulation of surviving T cells.
M. Maksimow, M. Santanen, S. Jalkanen, and A. Hanninen (2003)
Blood 101, 4022-4028
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Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.
M. Krampera, S. Glennie, J. Dyson, D. Scott, R. Laylor, E. Simpson, and F. Dazzi (2003)
Blood 101, 3722-3729
   Abstract »    Full Text »    PDF »
Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor {kappa}B in Regulating Mature T Cell Survival and In Vivo Function.
Y. Zheng, M. Vig, J. Lyons, L. Van Parijs, and A. A. Beg (2003)
J. Exp. Med. 197, 861-874
   Abstract »    Full Text »    PDF »
Display of Fas Ligand Protein on Cardiac Vasculature as a Novel Means of Regulating Allograft Rejection.
N. Askenasy, E. S. Yolcu, Z. Wang, and H. Shirwan (2003)
Circulation 107, 1525-1531
   Abstract »    Full Text »    PDF »
Anti-apoptotic Signaling by the Interleukin-2 Receptor Reveals a Function for Cytoplasmic Tyrosine Residues within the Common gamma (gamma c) Receptor Subunit.
M. J. Lindemann, M. Benczik, and S. L. Gaffen (2003)
J. Biol. Chem. 278, 10239-10249
   Abstract »    Full Text »    PDF »
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
S. Hori, T. Nomura, and S. Sakaguchi (2003)
Science 299, 1057-1061
   Abstract »    Full Text »    PDF »
Analysis of gamma c-Family Cytokine Target Genes. IDENTIFICATION OF DUAL-SPECIFICITY PHOSPHATASE 5 (DUSP5) AS A REGULATOR OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN INTERLEUKIN-2 SIGNALING.
P. E. Kovanen, A. Rosenwald, J. Fu, E. M. Hurt, L. T. Lam, J. M. Giltnane, G. Wright, L. M. Staudt, and W. J. Leonard (2003)
J. Biol. Chem. 278, 5205-5213
   Abstract »    Full Text »    PDF »
Tumour necrosis factor alpha in systemic lupus erythematosus and anti-DNA autoantibody production.
R A Mageed and D A Isenberg (2002)
Lupus 11, 850-855
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Engagement of Na,K-ATPase {beta}3 subunit by a specific mAb suppresses T and B lymphocyte activation.
S. Chiampanichayakul, A. Szekeres, P. Khunkaewla, S. Moonsom, V. Leksa, K. Drbal, G. J. Zlabinger, R. Hofer-Warbinek, H. Stockinger, and W. Kasinrerk (2002)
Int. Immunol. 14, 1407-1414
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Reversibility with Interleukin-2 Suggests that T Cell Anergy Contributes to Donor-Specific Hyporesponsiveness in Renal Transplant Patients.
W. F. Ng, M. Hernandez-Fuentes, R. Baker, A. Chaudhry, and R. I. Lechler (2002)
J. Am. Soc. Nephrol. 13, 2983-2989
   Abstract »    Full Text »    PDF »
Systemic Administration of IL-15 Augments the Antigen-Specific Primary CD8+ T Cell Response Following Vaccination with Peptide-Pulsed Dendritic Cells.
M. P. Rubinstein, A. N. Kadima, M. L. Salem, C. L. Nguyen, W. E. Gillanders, and D. J. Cole (2002)
J. Immunol. 169, 4928-4935
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Selective Delivery of Augmented IL-2 Receptor Signals to Responding CD8+ T Cells Increases the Size of the Acute Antiviral Response and of the Resulting Memory T Cell Pool.
L. E. Cheng and P. D. Greenberg (2002)
J. Immunol. 169, 4990-4997
   Abstract »    Full Text »    PDF »


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