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Science 10 April 1998:
Vol. 280. no. 5361, pp. 237 - 243
DOI: 10.1126/science.280.5361.237
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Articles

Natural and Engineered Disorders of Lymphocyte Development

Alain Fischer, Bernard Malissen *

Mammals have evolved complex developmental pathways to generate a large repertoire of B and T lymphocytes capable of mounting effective immune responses. Analysis of natural and engineered immunodeficiencies constitutes a powerful approach to delineating these pathways and identifying the molecular sensors that couple the survival of developing lymphocytes to the achievement of successful gene rearrangements at the loci coding for B and T cell antigen receptors. Besides identifying cytokines, growth factors, and transcription factors involved in lymphocyte development, genetic analysis also makes it possible to organize most of these protagonists into gene networks that control critical events in the life of developing lymphocytes.

A. Fischer is at Unité INSERM U.429, Hôpital Necker-Enfants Malades 149, Rue de Sèvres, 75743, Paris Cedex 15, France. B. Malissen is at the Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, 13288 Marseille Cedex 9, France.
*   To whom correspondence should be addressed.

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