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Science 20 March 1998:
Vol. 279. no. 5358, pp. 1961 - 1964
DOI: 10.1126/science.279.5358.1961
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Reports

Dependence of BSAP Repressor and Activator Functions on BSAP Concentration

Jeffrey J. Wallin, * Edwin R. Gackstetter, Marian Elliott Koshland dagger

During a B cell immune response, the transcription factor BSAP maintains its activator functions but is relieved of its repressor functions. This selective targeting of BSAP activities was shown to be regulated by a concentration-dependent mechanism whereby activator motifs for BSAP had a 20-fold higher binding affinity than repressor motifs. An exchange of activator and repressor motifs, however, showed that the context of the motif, rather than the affinity, determined whether BSAP operated as an activator or repressor.

Immunology Division, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
*   To whom correspondence should be addressed.

dagger    Deceased.

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