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Science 20 March 1998:
Vol. 279. no. 5358, pp. 1954 - 1958
DOI: 10.1126/science.279.5358.1954
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Reports

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

Wen-Chen Yeh, José Luis de la Pompa, Mila E. McCurrach, Hong-Bing Shu, Andrew J. Elia, Arda Shahinian, Michelle Ng, Andrew Wakeham, Wilson Khoo, Kyran Mitchell, Wafik S. El-Deiry, Scott W. Lowe, David V. Goeddel, Tak W. Mak *

FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c-myc, and chemotherapeutic agent adriamycin did. Mice with a deletion in the FADD gene did not survive beyond day 11.5 of embryogenesis; these mice showed signs of cardiac failure and abdominal hemorrhage. Chimeric embryos showing a high contribution of FADD null mutant cells to the heart reproduce the phenotype of FADD-deficient mutants. Thus, not only death receptors, but also receptors that couple to developmental programs, may use FADD for signaling.

W.-C. Yeh, J. L. de la Pompa, A. J. Elia, A. Shahinian, M. Ng, A. Wakeham, W. Khoo, T. W. Mak, Amgen Institute, Departments of Medical Biophysics and Immunology, University of Toronto, and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2C1, Canada.
M. E. McCurrach and S. W. Lowe, Cold Spring Harbor Laboratories, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
H.-B. Shu and D. V. Goeddel, Tularik, 2 Corporate Drive, South San Francisco, CA 94080, USA.
K. Mitchell and W. S. El-Deiry, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine CRB 437A, Philadelphia, PA 19104, USA.
*   To whom correspondence should be addressed. E-mail: t.mak{at}oci.utoronto.ca

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   Abstract »    Full Text »    PDF »
Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system.
K. Newton and A. Strasser (2003)
Genes & Dev. 17, 819-825
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Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation.
M. C. Marchetti, B. Di Marco, G. Cifone, G. Migliorati, and C. Riccardi (2003)
Blood 101, 585-593
   Abstract »    Full Text »    PDF »
LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level.
P. Ducoroy, O. Micheau, S. Perruche, L. Dubrez-Daloz, D. de Fornel, P. Dutartre, P. Saas, and E. Solary (2003)
Blood 101, 194-201
   Abstract »    Full Text »    PDF »
Hepatocyte Fas-associating Death Domain Protein/Mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli.
P. K. M. Kim, Y. Wang, A. Gambotto, Y.-M. Kim, R. Weller, B. S. Zuckerbraun, Y. Hua, S. C. Watkins, and T. R. Billiar (2002)
J. Biol. Chem. 277, 38855-38862
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Induces Apoptosis in Hepatoma Cells by Increasing Ca2+ Release from the Endoplasmic Reticulum and Suppressing Bcl-2 Expression.
B.-C. Kim, H.-T. Kim, M. Mamura, I. S. Ambudkar, K.-S. Choi, and S.-J. Kim (2002)
J. Biol. Chem. 277, 31381-31389
   Abstract »    Full Text »    PDF »
Resistance to Fas-mediated apoptosis in human lung fibroblast.
T. Tanaka, M. Yoshimi, T. Maeyama, N. Hagimoto, K. Kuwano, and N. Hara (2002)
Eur. Respir. J. 20, 359-368
   Abstract »    Full Text »    PDF »
c-Myc Controls Proliferation Versus Differentiation in Human Pancreatic Endocrine Cells.
C. Demeterco, P. Itkin-Ansari, B. Tyrberg, L. P. Ford, R. A. Jarvis, and F. Levine (2002)
J. Clin. Endocrinol. Metab. 87, 3475-3485
   Abstract »    Full Text »    PDF »
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms.
M. Morgan, J. Thorburn, P. P. Pandolfi, and A. Thorburn (2002)
J. Cell Biol. 157, 975-984
   Abstract »    Full Text »    PDF »
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.
M. S. Shin, H. S. Kim, C. S. Kang, W. S. Park, S. Y. Kim, S. N. Lee, J. H. Lee, J. Y. Park, J. J. Jang, C. W. Kim, et al. (2002)
Blood 99, 4094-4099
   Abstract »    Full Text »    PDF »
A Novel Zinc Finger Protein Interacts with Receptor-interacting Protein (RIP) and Inhibits Tumor Necrosis Factor (TNF)- and IL1-induced NF-kappa B Activation.
D. Chen, X. Li, Z. Zhai, and H.-B. Shu (2002)
J. Biol. Chem. 277, 15985-15991
   Abstract »    Full Text »    PDF »
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum.
D. G. Breckenridge, M. Nguyen, S. Kuppig, M. Reth, and G. C. Shore (2002)
PNAS 99, 4331-4336
   Abstract »    Full Text »    PDF »
Paclitaxel Triggers Cell Death Primarily via Caspase-independent Routes in the Non-Small Cell Lung Cancer Cell Line NCI-H460.
C. Huisman, C. G. Ferreira, L. E. Broker, J. A. Rodriguez, E. F. Smit, P. E. Postmus, F. A. E. Kruyt, and G. Giaccone (2002)
Clin. Cancer Res. 8, 596-606
   Abstract »    Full Text »    PDF »
Binding of FADD and Caspase-8 to Molluscum Contagiosum Virus MC159 v-FLIP Is Not Sufficient for Its Antiapoptotic Function.
T. L. Garvey, J. Bertin, R. M. Siegel, G.-h. Wang, M. J. Lenardo, and J. I. Cohen (2002)
J. Virol. 76, 697-706
   Abstract »    Full Text »    PDF »
Molecular Cross-talk between the TRAIL and Interferon Signaling Pathways.
C. Kumar-Sinha, S. Varambally, A. Sreekumar, and A. M. Chinnaiyan (2002)
J. Biol. Chem. 277, 575-585
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FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis.
A. Krueger, S. Baumann, P. H. Krammer, and S. Kirchhoff (2001)
Mol. Cell. Biol. 21, 8247-8254
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Fas Ligand Engagement of Resident Peritoneal Macrophages In Vivo Induces Apoptosis and the Production of Neutrophil Chemotactic Factors.
A. M. Hohlbaum, M. S. Gregory, S.-T. Ju, and A. Marshak-Rothstein (2001)
J. Immunol. 167, 6217-6224
   Abstract »    Full Text »    PDF »


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