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Science 20 March 1998:
Vol. 279. no. 5358, pp. 1922 - 1925
DOI: 10.1126/science.279.5358.1922
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Reports

Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

Jianming Xu, Yuhong Qiu, Francesco J. DeMayo, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley *

The in vivo biological function of a steroid receptor coactivator was assessed in mice in which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the homozygous mutants were viable and fertile, target organs such as uterus, prostate, testis, and mammary gland exhibited decreased growth and development in response to steroid hormones. Expression of RNA encoding TIF2, a member of the SRC-1 family, was increased in the SRC-1 null mutant, perhaps compensating partially for the loss of SRC-1 function in target tissues. The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone.

Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
*   To whom correspondence should be addressed. E-mail: berto{at}bcm.tmc.edu

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   Abstract »    Full Text »    PDF »
Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice.
U. I. L. Modder, A. Sanyal, A. E. Kearns, J. D. Sibonga, E. Nishihara, J. Xu, B. W. O'Malley, E. L. Ritman, B. L. Riggs, T. C. Spelsberg, et al. (2004)
Endocrinology 145, 913-921
   Abstract »    Full Text »    PDF »
Expression of Androgen Receptor Coregulators in Prostate Cancer.
M. J. Linja, K. P. Porkka, Z. Kang, K. J. Savinainen, O. A. Janne, T. L. J. Tammela, R. L. Vessella, J. J. Palvimo, and T. Visakorpi (2004)
Clin. Cancer Res. 10, 1032-1040
   Abstract »    Full Text »    PDF »
Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins.
D. M. Lonard, S. Y. Tsai, and B. W. O'Malley (2004)
Mol. Cell. Biol. 24, 14-24
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NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the {alpha}-Helical Region of the STAT5 Transactivation Domain.
C. M. Litterst, S. Kliem, D. Marilley, and E. Pfitzner (2003)
J. Biol. Chem. 278, 45340-45351
   Abstract »    Full Text »    PDF »
Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth.
G. Zhou, Y. Hashimoto, I. Kwak, S. Y. Tsai, and M.-J. Tsai (2003)
Mol. Cell. Biol. 23, 7742-7755
   Abstract »    Full Text »    PDF »
Nuclear Receptor Coactivator Function in Reproductive Physiology and Behavior.
H. A. Molenda, C. P. Kilts, R. L. Allen, and M. J. Tetel (2003)
Biol Reprod 69, 1449-1457
   Abstract »    Full Text »    PDF »
Unfolding the Action of Progesterone Receptors.
X. Li and B. W. O'Malley (2003)
J. Biol. Chem. 278, 39261-39264
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Review of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family.
J. Xu and Q. Li (2003)
Mol. Endocrinol. 17, 1681-1692
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Modulation by Steroid Receptor Coactivator-1 of Target-Tissue Responsiveness in Resistance to Thyroid Hormone.
Y. Kamiya, X.-Y. Zhang, H. Ying, Y. Kato, M. C. Willingham, J. Xu, B. W. O'Malley, and S.-Y. Cheng (2003)
Endocrinology 144, 4144-4153
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A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition.
J. C. Condon, P. Jeyasuria, J. M. Faust, J. W. Wilson, and C. R. Mendelson (2003)
PNAS 100, 9518-9523
   Abstract »    Full Text »    PDF »
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression.
K. De Bosscher, W. Vanden Berghe, and G. Haegeman (2003)
Endocr. Rev. 24, 488-522
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Is the Achilles' Heel for Prostate Cancer Therapy a Gain of Function in Androgen Receptor Signaling?.
I. V. Litvinov, A. M. De Marzo, and J. T. Isaacs (2003)
J. Clin. Endocrinol. Metab. 88, 2972-2982
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Progesterone and Glucocorticoid Receptors Recruit Distinct Coactivator Complexes and Promote Distinct Patterns of Local Chromatin Modification.
X. Li, J. Wong, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley (2003)
Mol. Cell. Biol. 23, 3763-3773
   Abstract »    Full Text »    PDF »
SAFB2, a New Scaffold Attachment Factor Homolog and Estrogen Receptor Corepressor.
S. M. Townson, K. M. Dobrzycka, A. V. Lee, M. Air, W. Deng, K. Kang, S. Jiang, N. Kioka, K. Michaelis, and S. Oesterreich (2003)
J. Biol. Chem. 278, 20059-20068
   Abstract »    Full Text »    PDF »
Involvement of Histone Acetylation in Ovarian Steroid-induced Decidualization of Human Endometrial Stromal Cells.
N. Sakai, T. Maruyama, R. Sakurai, H. Masuda, Y. Yamamoto, A. Shimizu, I. Kishi, H. Asada, S. Yamagoe, and Y. Yoshimura (2003)
J. Biol. Chem. 278, 16675-16682
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Thyroid Hormone Receptor-Specific Interactions with Steroid Receptor Coactivator-1 in the Pituitary.
P. M. Sadow, E. Koo, O. Chassande, K. Gauthier, J. Samarut, J. Xu, B. W. O'Malley, H. Seo, Y. Murata, and R. E. Weiss (2003)
Mol. Endocrinol. 17, 882-894
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Vitamin D: More Than a "Bone-a-Fide" Hormone.
A. L. M. Sutton and P. N. MacDonald (2003)
Mol. Endocrinol. 17, 777-791
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Spatial Distribution of the Messenger Ribonucleic Acid and Protein of the Nuclear Receptor Coactivator, Amplified in Breast Cancer-3, in Mice.
H. Zhang, L. Liao, S.-Q. Kuang, and J. Xu (2003)
Endocrinology 144, 1435-1443
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Inactivation of the Nuclear Receptor Coactivator RAP250 in Mice Results in Placental Vascular Dysfunction.
P. Antonson, G. U. Schuster, L. Wang, B. Rozell, E. Holter, P. Flodby, E. Treuter, L. Holmgren, and J.-A. Gustafsson (2003)
Mol. Cell. Biol. 23, 1260-1268
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Coactivator PRIP, the Peroxisome Proliferator-activated Receptor-interacting Protein, Is a Modulator of Placental, Cardiac, Hepatic, and Embryonic Development.
Y.-J. Zhu, S. E. Crawford, V. Stellmach, R. S. Dwivedi, M. S. Rao, F. J. Gonzalez, C. Qi, and J. K. Reddy (2003)
J. Biol. Chem. 278, 1986-1990
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SRC-1 Null Mice Exhibit Moderate Motor Dysfunction and Delayed Development of Cerebellar Purkinje Cells.
E. Nishihara, H. Yoshida-Komiya, C.-S. Chan, L. Liao, R. L. Davis, B. W. O'Malley, and J. Xu (2003)
J. Neurosci. 23, 213-222
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