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Science 20 March 1998:
Vol. 279. no. 5358, pp. 1882 - 1886
DOI: 10.1126/science.279.5358.1882
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Articles

Gas-Phase Ionic Reactions: Dynamics and Mechanism of Nucleophilic Displacements

Michael L. Chabinyc, Stephen L. Craig, Colleen K. Regan, John I. Brauman *

Nucleophilic displacement reactions (the SN2 reaction) of ions in the gas phase are a prototypical reaction system that allows a study of dynamics, mechanisms, and structure-energy relations. This article reviews aspects of the kinetics (especially the applicability of statistical reaction rate theory), the relation of structure and reactivity, and the effects of small numbers of solvent molecules on the reaction and compares the behavior of the ionic reaction in the gas phase with that in solution.

M. L. Chabinyc, C. K. Regan, and J. I. Brauman are in the Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA. S. L. Craig is in the Central Research and Development Department, E. I. DuPont de Nemours and Company, Incorporated, Wilmington, DE 19880-0328, USA.
*   To whom correspondence should be addressed. E-mail: brauman{at}stanford.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Imaging Nucleophilic Substitution Dynamics.
J. Mikosch, S. Trippel, C. Eichhorn, R. Otto, U. Lourderaj, J. X. Zhang, W. L. Hase, M. Weidemuller, and R. Wester (2008)
Science 319, 183-186
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Water Catalysis of a Radical-Molecule Gas-Phase Reaction.
E. Vohringer-Martinez, B. Hansmann, H. Hernandez, J. S. Francisco, J. Troe, and B. Abel (2007)
Science 315, 497-501
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A SN2 Reaction That Avoids Its Deep Potential Energy Minimum.
L. Sun, K. Song, and W. L. Hase (2002)
Science 296, 875-878
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Steric Effects and Solvent Effects in Ionic Reactions.
C. K. Regan, S. L. Craig, and J. I. Brauman (2002)
Science 295, 2245-2247
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Solvation, Reorganization Energy, and Biological Catalysis.
W. R. Cannon and S. J. Benkovic (1998)
J. Biol. Chem. 273, 26257-26260
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