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Science 13 March 1998:
Vol. 279. no. 5357, pp. 1737 - 1740
DOI: 10.1126/science.279.5357.1737
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Reports

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial gamma &dgr; T Cells

Veronika Groh, * Alexander Steinle, Stefan Bauer, Thomas Spies *

T cells with variable region Vdelta 1 gamma delta T cell receptors (TCRs) are distributed throughout the human intestinal epithelium and may function as sentinels that respond to self antigens. The expression of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization. MICA and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vdelta 1 gamma delta TCRs. These interactions involved the alpha 1alpha 2 domains of MICA and MICB but were independent of antigen processing. With intestinal epithelial cell lines, the expression and recognition of MICA and MICB could be stress-induced. Thus, these molecules may broadly regulate protective responses by the Vdelta 1 gamma delta T cells in the epithelium of the intestinal tract.

Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
*   To whom correspondence should be addressed. E-mail: vgroh{at}fred.fhcrc.org, tspies{at}fred.fhcrc.org

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Structural Studies of Allelic Diversity of the MHC Class I Homolog MIC-B, a Stress-Inducible Ligand for the Activating Immunoreceptor NKG2D.
M. A. Holmes, P. Li, E. W. Petersdorf, and R. K. Strong (2002)
J. Immunol. 169, 1395-1400
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T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping.
W. Holtmeier, A. Hennemann, E. May, R. Duchmann, and W. F. Caspary (2002)
Am J Physiol Gastrointest Liver Physiol 282, G1024-G1034
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Patterns of Chemokine Receptor Expression on Peripheral Blood {gamma}{delta} T Lymphocytes: Strong Expression of CCR5 Is a Selective Feature of V{delta}2/V{gamma}9 {gamma}{delta} T Cells.
A. Glatzel, D. Wesch, F. Schiemann, E. Brandt, O. Janssen, and D. Kabelitz (2002)
J. Immunol. 168, 4920-4929
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CD8{alpha}-Deficient Mice Are Highly Susceptible to 5-Fluorouracil-Induced Lethality.
N. Itoh, H. Nishimura, T. Matsuguchi, T. Yajima, Y. Mokuno, T. Hiromatsu, Y. Nimura, and Y. Yoshikai (2002)
Clin. Vaccine Immunol. 9, 550-557
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Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28.
L. L. Molinero, M. B. Fuertes, G. A. Rabinovich, L. Fainboim, and N. W. Zwirner (2002)
J. Leukoc. Biol. 71, 791-797
   Abstract »    Full Text »    PDF »
The Danger Model: A Renewed Sense of Self.
P. Matzinger (2002)
Science 296, 301-305
   Abstract »    Full Text »    PDF »
Induction of T cell alertness by bacterial colonization of intestinal epithelium.
T. Spies (2002)
PNAS 99, 2584-2586
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MHC class I chain related gene A (MICA) modulates the development of coeliac disease in patients with the high risk heterodimer DQA1*0501/DQB1*0201.
A Lopez-Vazquez, L Rodrigo, D Fuentes, S Riestra, C Bousono, S Garcia-Fernandez, J Martinez-Borra, S Gonzalez, and C Lopez-Larrea (2002)
Gut 50, 336-340
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A basolateral sorting motif in the MICA cytoplasmic tail.
H. Suemizu, M. Radosavljevic, M. Kimura, S. Sadahiro, S. Yoshimura, S. Bahram, and H. Inoko (2002)
PNAS
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Essential Contribution of Germline-Encoded Lysine Residues in J{gamma}1.2 Segment to the Recognition of Nonpeptide Antigens by Human {gamma}{delta} T Cells.
F. Miyagawa, Y. Tanaka, S. Yamashita, B. Mikami, K. Danno, M. Uehara, and N. Minato (2001)
J. Immunol. 167, 6773-6779
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Targeting of Tumor Cells for Human {gamma}{delta} T Cells by Nonpeptide Antigens.
Y. Kato, Y. Tanaka, F. Miyagawa, S. Yamashita, and N. Minato (2001)
J. Immunol. 167, 5092-5098
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Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens.
N. Kadowaki, S. Ho, S. Antonenko, R. de Waal Malefyt, R. A. Kastelein, F. Bazan, and Y.-J. Liu (2001)
J. Exp. Med. 194, 863-870
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Curcumin Inhibits Activation of V{gamma}9V{delta}2 T Cells by Phosphoantigens and Induces Apoptosis Involving Apoptosis-Inducing Factor and Large Scale DNA Fragmentation.
B. Cipriani, G. Borsellino, H. Knowles, D. Tramonti, F. Cavaliere, G. Bernardi, L. Battistini, and C. F. Brosnan (2001)
J. Immunol. 167, 3454-3462
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Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema.
J. Majo, H. Ghezzo, and M.G. Cosio (2001)
Eur. Respir. J. 17, 946-953
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Perturbation and Proinflammatory Type Activation of V{delta}1+ {gamma}{delta} T Cells in African Children with Plasmodium falciparum Malaria.
L. Hviid, J. A. L. Kurtzhals, V. Adabayeri, S. Loizon, K. Kemp, B. Q. Goka, A. Lim, O. Mercereau-Puijalon, B. D. Akanmori, and C. Behr (2001)
Infect. Immun. 69, 3190-3196
   Abstract »    Full Text »    PDF »
Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism.
A. Takagi, T. Matsuzaki, M. Sato, K. Nomoto, M. Morotomi, and T. Yokokura (2001)
Carcinogenesis 22, 599-605
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The Restricted Expression of Granzyme M in Human Lymphocytes.
T. J. Sayers, A. D. Brooks, J. M. Ward, T. Hoshino, W. E. Bere, G. W. Wiegand, J. M. Kelley, and M. J. Smyth (2001)
J. Immunol. 166, 765-771
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MICA Polymorphism Is Associated With Type 1 Diabetes in the Korean Population.
Y. Park, H. Lee, C. B. Sanjeevi, and G. S. Eisenbarth (2001)
Diabetes Care 24, 33-38
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Localization of the Pathogenic Gene of Behcet's Disease by Microsatellite Analysis of Three Different Populations.
N. Mizuki, M. Ota, K. Yabuki, Y. Katsuyama, H. Ando, G. D. Palimeris, E. Kaklamani, M. Accorinti, P. Pivetti-Pezzi, S. Ohno, et al. (2000)
Invest. Ophthalmol. Vis. Sci. 41, 3702-3708
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The Ins and Outs of Body Surface Immunology.
A. Hayday and J. L. Viney (2000)
Science 290, 97-100
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DAP10 and DAP12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells.
J. Wu, H. Cherwinski, T. Spies, J. H. Phillips, and L. L. Lanier (2000)
J. Exp. Med. 192, 1059-1068
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gamma delta Cells and the Regulation of Mucosal Immune Responses.
A. C. HAYDAY, S. ROBERTS, and E. RAMSBURG (2000)
Am. J. Respir. Crit. Care Med. 162, S161-163
   Abstract »    Full Text »    PDF »


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