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Science 13 March 1998:
Vol. 279. no. 5357, pp. 1729 - 1733
DOI: 10.1126/science.279.5357.1729
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Reports

Conservation of T Cell Receptor Conformation in Epidermal gamma &dgr; Cells with Disrupted Primary Vgamma Gene Usage

Caroline A. Mallick-Wood, Julia M. Lewis, Lauren I. Richie, Michael J. Owen, Robert E. Tigelaar, * Adrian C. Hayday *dagger

A feature that distinguishes gamma delta T cell subsets from most alpha beta T cells and B cells is the association of expression of single T cell receptor (TCR) gamma  and delta  variable (V) region gene segments with specific anatomic sites. Mice lacking the TCR Vgamma 5 chain normally expressed by most dendritic epidermal T cells were shown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vgamma 5+ cells. Conservation by shuffled gamma delta TCR chains of an idiotype associated with a specific anatomic site indicates that for TCRgamma delta , as for immunoglobulin, conformation is associated to a greater extent with the function or development of lymphocyte repertoires than is the use of particular gene segments.

C. A. Mallick-Wood, L. I. Richie, A. C. Hayday, Department of Molecular, Cell, and Developmental Biology and Section of Immunobiology, Yale University, New Haven, CT 06520, USA.
J. M. Lewis and R. E. Tigelaar, Department of Dermatology and Section of Immunobiology, Yale University, New Haven, CT 06511, USA.
M. J. Owen, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK.
*   These authors contributed equally to this report.

dagger    To whom correspondence should be addressed. E-mail: adrian.hayday{at}yale.edu

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