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Science 13 March 1998:
Vol. 279. no. 5357, pp. 1725 - 1729
DOI: 10.1126/science.279.5357.1725
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Reports

Hyperinnervation of Neuromuscular Junctions Caused by GDNF Overexpression in Muscle

Quyen T. Nguyen, * Alexander Sh. Parsadanian, * William D. Snider, Jeff W. Lichtman dagger

Overexpression of glial cell line-derived neurotrophic factor (GDNF) by muscle greatly increased the number of motor axons innervating neuromuscular junctions in neonatal mice. The extent of hyperinnervation correlated with the amount of GDNF expressed in four transgenic lines. Overexpression of GDNF by glia and overexpression of neurotrophin-3 and neurotrophin-4 in muscle did not cause hyperinnervation. Thus, increased amounts of GDNF in postsynaptic target cells can regulate the number of innervating axons.

Q. T. Nguyen and J. W. Lichtman, Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
A. Sh. Parsadanian and W. D. Snider, Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
*   These authors contributed equally to this report.

dagger    To whom correspondence should be addressed. E-mail: jeff{at}thalamus.wustl.edu

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