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Science 6 March 1998:
Vol. 279. no. 5356, pp. 1528 - 1530
DOI: 10.1126/science.279.5356.1528
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Reports

Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

Giuliana Ferrari, Gabriella Cusella-, De Angelis, Marcello Coletta, Egle Paolucci, Anna Stornaiuolo, Giulio Cossu, * Fulvio Mavilio *

Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies.

G. Ferrari, E. Paolucci, A. Stornaiuolo, F. Mavilio, H. San Raffaele-Telethon Institute for Gene Therapy (TIGET), 20132 Milan, Italy.
G. Cusella-De Angelis, Istituto di Anatomia Umana Normale, University of Pavia, 27100 Pavia, Italy.
M. Coletta and G. Cossu, Istituto Pasteur-Fondazione Cenci-Bolognetti,Dipartimento di Istologia ed Embriologia Medica, University of Rome "La Sapienza", 00161 Rome, Italy.
*   To whom correspondence should be addressed. E-mail: cossu{at}axrma.uniroma1.it (G.C.) or mavilio{at}tigem.it (F.M.).

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Pituitary Transcription Factor-1 Induces Transient Differentiation of Adult Hepatic Stem Cells into Prolactin-Producing Cells in Vivo.
E. J. Lee, T. Russell, L. Hurley, and J. L. Jameson (2005)
Mol. Endocrinol. 19, 964-971
   Abstract »    Full Text »    PDF »
From The Cover: Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells.
T. Kondo, S. A. Johnson, M. C. Yoder, R. Romand, and E. Hashino (2005)
PNAS 102, 4789-4794
   Abstract »    Full Text »    PDF »
Can stem cells mend a broken heart?.
S. Davani, F. Deschaseaux, D. Chalmers, P. Tiberghien, and J.-P. Kantelip (2005)
Cardiovasc Res 65, 305-316
   Abstract »    Full Text »    PDF »
HSCs for muscular dystrophy: a paradigm shift, back.
J. F. Tisdale (2004)
Blood 104, 3847-3848
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Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs.
C. Dell'Agnola, Z. Wang, R. Storb, S. J. Tapscott, C. S. Kuhr, S. D. Hauschka, R. S. Lee, G. E. Sale, E. Zellmer, S. Gisburne, et al. (2004)
Blood 104, 4311-4318
   Abstract »    Full Text »    PDF »
Transplanted human bone marrow contributes to vascular endothelium.
S. Jiang, L. Walker, M. Afentoulis, D. A. Anderson, L. Jauron-Mills, C. L. Corless, and W. H. Fleming (2004)
PNAS 101, 16891-16896
   Abstract »    Full Text »    PDF »
Differentiation of Bone Marrow Stromal Cells Into the Cardiac Phenotype Requires Intercellular Communication With Myocytes.
M. Xu, M. Wani, Y.-S. Dai, J. Wang, M. Yan, A. Ayub, and M. Ashraf (2004)
Circulation 110, 2658-2665
   Abstract »    Full Text »    PDF »
Proteomic Profiling of Bone Marrow Mesenchymal Stem Cells upon Transforming Growth Factor {beta}1 Stimulation.
D. Wang, J. S. Park, J. S. F. Chu, A. Krakowski, K. Luo, D. J. Chen, and S. Li (2004)
J. Biol. Chem. 279, 43725-43734
   Abstract »    Full Text »    PDF »
Fusion-independent expression of functional ACh receptors in mouse mesoangioblast stem cells contacting muscle cells.
F. Grassi, F. Pagani, G. Spinelli, L. De Angelis, G. Cossu, and F. Eusebi (2004)
J. Physiol. 560, 479-489
   Abstract »    Full Text »    PDF »
Mesenchymal Stem Cells and the Artery Wall.
M. Abedin, Y. Tintut, and L. L. Demer (2004)
Circ. Res. 95, 671-676
   Abstract »    Full Text »    PDF »
Hemodynamic Regulation of CD34+ Cell Localization and Differentiation in Experimental Aneurysms.
E. Sho, M. Sho, H. Nanjo, K. Kawamura, H. Masuda, and R. L. Dalman (2004)
Arterioscler Thromb Vasc Biol 24, 1916-1921
   Abstract »    Full Text »    PDF »
Regenerative capacity of the dystrophic (mdx) diaphragm after induced injury.
S. Matecki, G. H. Guibinga, and B. J. Petrof (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R961-R968
   Abstract »    Full Text »    PDF »
Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors.
R. Doyonnas, M. A. LaBarge, A. Sacco, C. Charlton, and H. M. Blau (2004)
PNAS 101, 13507-13512
   Abstract »    Full Text »    PDF »
Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells.
A. Hermann, R. Gastl, S. Liebau, M. O. Popa, J. Fiedler, B. O. Boehm, M. Maisel, H. Lerche, J. Schwarz, R. Brenner, et al. (2004)
J. Cell Sci. 117, 4411-4422
   Abstract »    Full Text »    PDF »


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