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Science 27 February 1998:
Vol. 279. no. 5355, pp. 1371 - 1373
DOI: 10.1126/science.279.5355.1371
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Reports

Changes in Auxin Response from Mutations in an AUX/IAA Gene

Dean Rouse, Pamela Mackay, Petra Stirnberg, Mark Estelle, Ottoline Leyser *

Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin, but evidence that AUX/IAA genes mediate further responses to auxin has been elusive. Changes in diverse auxin responses result from mutations in the Arabidopsis AXR3 gene. AXR3 was shown to be a member of the AUX/IAA family, providing direct evidence that AUX/IAA genes are central in auxin signaling. Molecular characterization of axr3 gain-of-function and loss-of-function mutations established the functional importance of domains conserved among AUX/IAA proteins.

D. Rouse, P. Mackay, P. Stirnberg, O. Leyser, Department of Biology, University of York, York YO1 5YW, UK.
M. Estelle, Department of Biology, Indiana University, Bloomington, IN 47405, USA.
*   To whom correspondence should be addressed. E-mail: hmol1{at}york.ac.uk

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