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Science 13 February 1998:
Vol. 279. no. 5353, pp. 1054 - 1057
DOI: 10.1126/science.279.5353.1054
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Reports

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

Joke M. M. den Haan, * Leslie M. Meadows, * Wei Wang, * Jos Pool, * Els Blokland, Tracie L. Bishop, Carla Reinhardus, Jeffrey Shabanowitz, Rienk Offringa, Donald F. Hunt, Victor H. Engelhard, Els Goulmy dagger

The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development.

J. M. M. den Haan, J. Pool, E. Blokland, C. Reinhardus, R. Offringa, E. Goulmy, Department of Immunohematology and Bloodbank, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
L. M. Meadows, T. L. Bishop, J. Shabanowitz, Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.
W. Wang and V. H. Engelhard, Department of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.
D. F. Hunt, Departments of Chemistry and Pathology, University of Virginia, Charlottesville, VA 22901, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: ihbsecr{at}euronet.nl

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