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Science 30 January 1998:
Vol. 279. no. 5351, pp. 700 - 703
DOI: 10.1126/science.279.5351.700
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Reports

Differential Use of CREB Binding Protein-Coactivator Complexes

Riki Kurokawa, Daniel Kalafus, Marie-Hélène Ogliastro, Chrissa Kioussi, Lan Xu, Joseph Torchia, Michael G. Rosenfeld, Christopher K. Glass

CREB binding protein (CBP) functions as an essential coactivator of transcription factors that are inhibited by the adenovirus early gene product E1A. Transcriptional activation by the signal transducer and activator of transcription-1 (STAT1) protein requires the C/H3 domain in CBP, which is the primary target of E1A inhibition. Here it was found that the C/H3 domain is not required for retinoic acid receptor (RAR) function, nor is it involved in E1A inhibition. Instead, E1A inhibits RAR function by preventing the assembly of CBP-nuclear receptor coactivator complexes, revealing differences in required CBP domains for transcriptional activation by RAR and STAT1.

R. Kurokawa, M.-H. Ogliastro, C. K. Glass, Divisions of Cellular and Molecular Medicine and Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.
D. Kalafus, Divisions of Cellular and Molecular Medicine and Endocrinology and Metabolism and Biomedical Sciences Graduate Program, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.
C. Kioussi, J. Torchia, M. G. Rosenfeld, Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.
L. Xu, Biomedical Sciences Graduate Program, and Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA.
*   To whom correspondence should be addressed. E-mail: cglass{at}ucsd.edu

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   Abstract »    Full Text »
Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins.
P. Webb, P. Nguyen, J. Shinsako, C. Anderson, W. Feng, M. P. Nguyen, D. Chen, S.-M. Huang, S. Subramanian, E. McKinerney, et al. (1998)
Mol. Endocrinol. 12, 1605-1618
   Abstract »    Full Text »
Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro.
A. M. Näär, P. A. Beaurang, K. M. Robinson, J. D. Oliner, D. Avizonis, S. Scheek, J. Zwicker, J. T. Kadonaga, and R. Tjian (1998)
Genes & Dev. 12, 3020-3031
   Abstract »    Full Text »
Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.
Y.-T. Juang, W. Lowther, M. Kellum, W.-C. Au, R. Lin, J. Hiscott, and P. M. Pitha (1998)
PNAS 95, 9837-9842
   Abstract »    Full Text »    PDF »
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta  transcriptional responses in endothelial cells.
J. N. Topper, M. R. DiChiara, J. D. Brown, A. J. Williams, D. Falb, T. Collins, and M. A. Gimbrone Jr. (1998)
PNAS 95, 9506-9511
   Abstract »    Full Text »    PDF »
Transactivation by Retinoid X Receptor-Peroxisome Proliferator-Activated Receptor gamma  (PPARgamma ) Heterodimers: Intermolecular Synergy Requires Only the PPARgamma Hormone-Dependent Activation Function.
I. G. Schulman, G. Shao, and R. A. Heyman (1998)
Mol. Cell. Biol. 18, 3483-3494
   Abstract »    Full Text »
Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions.
E. Korzus, J. Torchia, D. W. Rose, L. Xu, R. Kurokawa, E. M. McInerney, T. Mullen, C. K. Glass, and M. G. Rosenfeld (1998)
Science 279, 703-707
   Abstract »    Full Text »
Insulin Responsiveness of the Glucagon Gene Conferred by Interactions between Proximal Promoter and More Distal Enhancer-like Elements Involving the Paired-domain Transcription Factor Pax6.
R. Grzeskowiak, J. Amin, E. Oetjen, and W. Knepel (2000)
J. Biol. Chem. 275, 30037-30045
   Abstract »    Full Text »    PDF »
Adenovirus E1A Down-regulates LMP2 Transcription by Interfering with the Binding of Stat1 to IRF1.
M. Chatterjee-Kishore, F. van den Akker, and G. R. Stark (2000)
J. Biol. Chem. 275, 20406-20411
   Abstract »    Full Text »    PDF »
E1A12S-mediated Activation of the Adenovirus Type 12 E2 Promoter Depends on the Histone Acetyltransferase Activity of p300/CBP.
P. Fax, O. Lehmkuhler, C. Kuhn, H. Esche, and D. Brockmann (2000)
J. Biol. Chem. 275, 40554-40560
   Abstract »    Full Text »    PDF »
Calcium and cAMP Signals Differentially Regulate cAMP-responsive Element-binding Protein Function via a Rap1-Extracellular Signal-regulated Kinase Pathway.
S. S. Grewal, D. M. Fass, H. Yao, C. L. Ellig, R. H. Goodman, and P. J. S. Stork (2000)
J. Biol. Chem. 275, 34433-34441
   Abstract »    Full Text »    PDF »
Evidence for a Common Step in Three Different Processes for Modulating the Kinetic Properties of Glucocorticoid Receptor-induced Gene Transcription.
S. Chen, N. J. Sarlis, and S. S. Simons Jr. (2000)
J. Biol. Chem. 275, 30106-30117
   Abstract »    Full Text »    PDF »
Synergistic, p160 Coactivator-dependent Enhancement of Estrogen Receptor Function by CARM1 and p300.
D. Chen, S.-M. Huang, and M. R. Stallcup (2000)
J. Biol. Chem. 275, 40810-40816
   Abstract »    Full Text »    PDF »
Stimulation of p300-mediated Transcription by the Kinase MEKK1.
R. H. See, D. Calvo, Y. Shi, H. Kawa, M. P.-S. Luke, Z. Yuan, and Y. Shi (2001)
J. Biol. Chem. 276, 16310-16317
   Abstract »    Full Text »    PDF »
Binding of p300/CBP Co-activators by Polyoma Large T Antigen.
S. Cho, Y. Tian, and T. L. Benjamin (2001)
J. Biol. Chem. 276, 33533-33539
   Abstract »    Full Text »    PDF »
The POU Domain Factor Skin-1a Represses the Keratin 14 Promoter Independent of DNA Binding. A POSSIBLE ROLE FOR INTERACTIONS BETWEEN Skn-1a AND CREB-BINDING PROTEIN/p300.
T. M. Sugihara, E. I. Kudryavtseva, V. Kumar, J. J. Horridge, and B. Andersen (2001)
J. Biol. Chem. 276, 33036-33044
   Abstract »    Full Text »    PDF »
Role of CBP/p300 and SRC-1 in Transcriptional Regulation of the Pulmonary Surfactant Protein-A (SP-A) Gene by Thyroid Transcription Factor-1 (TTF-1).
M. Yi, G.-X. Tong, B. Murry, and C. R. Mendelson (2002)
J. Biol. Chem. 277, 2997-3005
   Abstract »    Full Text »    PDF »
Coregulator Codes of Transcriptional Regulation by Nuclear Receptors.
M. G. Rosenfeld and C. K. Glass (2001)
J. Biol. Chem. 276, 36865-36868
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