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Science 23 January 1998:
Vol. 279. no. 5350, pp. 580 - 585
DOI: 10.1126/science.279.5350.580
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Reports

Interaction of a Golgi-Associated Kinesin-Like Protein with Rab6

Arnaud Echard, Florence Jollivet, Olivier Martinez, Jean-Jacques Lacapère, Annie Rousselet, Isabelle Janoueix-Lerosey, Bruno Goud *

Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.

A. Echard, F. Jollivet, O. Martinez, J.-J. Lacapère, A. Rousselet, B. Goud, Unité Mixte de Recherche CNRS 144 et 168, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
I. Janoueix-Lerosey, INSERM U 248, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
*   To whom correspondence should be addressed. E-mail: bgoud{at}curie.fr

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   Abstract »    Full Text »    PDF »
Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase.
J. G. Duman, K. Tyagarajan, M. S. Kolsi, H.-P. H. Moore, and J. G. Forte (1999)
Am J Physiol Cell Physiol 277, C361-C372
   Abstract »    Full Text »    PDF »
The Developmental Role of warthog, the Notch Modifier Encoding Drab6.
K. Purcell and S. Artavanis-Tsakonas (1999)
J. Cell Biol. 146, 731-740
   Abstract »    Full Text »    PDF »
Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport.
C. Dumanchin, C. Czech, D. Campion, M. H. Cuif, T. Poyot, C. Martin, F. Charbonnier, B. Goud, L. Pradier, and T. Frebourg (1999)
Hum. Mol. Genet. 8, 1263-1269
   Abstract »    Full Text »    PDF »
Vascular Endothelial Genes That Are Responsive to Tumor Necrosis Factor-{alpha} In Vitro Are Expressed in Atherosclerotic Lesions, Including Inhibitor of Apoptosis Protein-1, Stannin, and Two Novel Genes.
A. J.G. Horrevoets, R. D. Fontijn, A. J. van Zonneveld, C. J.M. de Vries, J. W. ten Cate, and H. Pannekoek (1999)
Blood 93, 3418-3431
   Abstract »    Full Text »    PDF »
Specific Isoforms of Actin-binding Proteins on Distinct Populations of Golgi-derived Vesicles.
K. Heimann, J. M. Percival, R. Weinberger, P. Gunning, and J. L. Stow (1999)
J. Biol. Chem. 274, 10743-10750
   Abstract »    Full Text »    PDF »
Identification of a putative effector protein for rab11 that participates in transferrin recycling.
J. Zeng, M. Ren, D. Gravotta, C. De Lemos-Chiarandini, M. Lui, H. Erdjument-Bromage, P. Tempst, G. Xu, T. H. Shen, T. Morimoto, et al. (1999)
PNAS 96, 2840-2845
   Abstract »    Full Text »    PDF »
Dynamic association of cytoplasmic dynein heavy chain 1a with the Golgi apparatus and intermediate compartment.
C Roghi and V. Allan (1999)
J. Cell Sci. 112, 4673-4685
   Abstract »    PDF »
The Golgi-targeting sequence of the peripheral membrane protein p230.
L Kjer-Nielsen, C van Vliet, R Erlich, B. Toh, and P. Gleeson (1999)
J. Cell Sci. 112, 1645-1654
   Abstract »    PDF »
GTP-Binding Proteins and Regulated Exocytosis.
E.L. Watson (1999)
Critical Reviews in Oral Biology & Medicine 10, 284-306
   Abstract »    Full Text »    PDF »
Association of Rab25 and Rab11a with the Apical Recycling System of Polarized Madin-Darby Canine Kidney Cells.
J. E. Casanova, X. Wang, R. Kumar, S. G. Bhartur, J. Navarre, J. E. Woodrum, Y. Altschuler, G. S. Ray, and J. R. Goldenring (1999)
Mol. Biol. Cell 10, 47-61
   Abstract »    Full Text »


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