Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 January 1998:
Vol. 279. no. 5350, pp. 570 - 573
DOI: 10.1126/science.279.5350.570
Prev | Table of Contents | Next

Reports

Inhibitory Cerebello-Olivary Projections and Blocking Effect in Classical Conditioning

Jeansok J. Kim, *dagger David J. Krupa, Richard F. Thompson

The behavioral phenomenon of blocking indicates that the informational relationship between the conditioned stimulus and the unconditioned stimulus is essential in classical conditioning. The eyeblink conditioning paradigm is used to describe a neural mechanism that mediates blocking. Disrupting inhibition of the inferior olive, a structure that conveys unconditioned stimulus information (airpuff) to the cerebellum prevented blocking in rabbits. Recordings of cerebellar neuronal activity show that the inferior olive input to the cerebellum becomes suppressed as learning occurs. These results suggest that the inferior olive becomes functionally inhibited by the cerebellum during conditioning, and that this negative feedback process might be the neural mechanism mediating blocking.

Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA.
*   To whom correspondence should be addressed. E-mail: jeansok.kim{at}yale.edu

dagger    Present address: Department of Psychology, 2 Hillhouse Avenue, Yale University, New Haven, CT 06520-8205, USA.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Extinction of a Classically Conditioned Response: Red Nucleus and Interpositus.
K. Robleto and R. F. Thompson (2008)
J. Neurosci. 28, 2651-2658
   Abstract »    Full Text »    PDF »
Impaired Motor Learning in the Vestibulo-Ocular Reflex in Mice with Multiple Climbing Fiber Input to Cerebellar Purkinje Cells.
R. R. Kimpo and J. L. Raymond (2007)
J. Neurosci. 27, 5672-5682
   Abstract »    Full Text »    PDF »
Adaptation in the Auditory Space Map of the Barn Owl.
Y. Gutfreund and E. I. Knudsen (2006)
J Neurophysiol 96, 813-825
   Abstract »    Full Text »    PDF »
Predicting danger: The nature, consequences, and neural mechanisms of predictive fear learning..
G. P. McNally and R. F. Westbrook (2006)
Learn. Mem. 13, 245-253
   Abstract »    Full Text »    PDF »
Motor Coding in Floccular Climbing Fibers.
B. Winkelman and M. Frens (2006)
J Neurophysiol 95, 2342-2351
   Abstract »    Full Text »    PDF »
Pontine stimulation overcomes developmental limitations in the neural mechanisms of eyeblink conditioning.
J. H. Freeman Jr., C. A. Rabinak, and M. M. Campolattaro (2005)
Learn. Mem. 12, 255-259
   Abstract »    Full Text »    PDF »
Brain Mechanisms of Extinction of the Classically Conditioned Eyeblink Response.
K. Robleto, A. M. Poulos, and R. F. Thompson (2004)
Learn. Mem. 11, 517-524
   Abstract »    Full Text »    PDF »
Opioid Receptors in the Midbrain Periaqueductal Gray Regulate Extinction of Pavlovian Fear Conditioning.
G. P. McNally, M. Pigg, and G. Weidemann (2004)
J. Neurosci. 24, 6912-6919
   Abstract »    Full Text »    PDF »
Extending In Vitro Conditioning in Aplysia to Analyze Operant and Classical Processes in the Same Preparation.
B. Brembs, D. A. Baxter, and J. H. Byrne (2004)
Learn. Mem. 11, 412-420
   Abstract »    Full Text »    PDF »
Response to Comment on "Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses".
C. I. De Zeeuw, Y. Elgersma, H. C. Hulscher, B. R. Dortland, R. A. Hensbroek, T. J. H. Ruigrok, and S. K. E. Koekkoek (2004)
Science 304, 211c
   Full Text »    PDF »
Developmental Changes in the Neural Mechanisms of Eyeblink Conditioning.
J. H. Freeman Jr. and D. A. Nicholson (2004)
Behav Cogn Neurosci Rev 3, 3-13
   Abstract »    PDF »
Inhibiting the Expression of a Classically Conditioned Behavior Prevents Its Extinction.
D. J. Krupa and R. F. Thompson (2003)
J. Neurosci. 23, 10577-10584
   Abstract »    Full Text »    PDF »
Neural Substrates of Eyeblink Conditioning: Acquisition and Retention.
K. M. Christian and R. F. Thompson (2003)
Learn. Mem. 10, 427-455
   Abstract »    Full Text »    PDF »
Developmental Changes in Eyeblink Conditioning and Neuronal Activity in the Pontine Nuclei.
J. H. Freeman Jr. and A. S. Muckler (2003)
Learn. Mem. 10, 337-345
   Abstract »    Full Text »    PDF »
Gated Visual Input to the Central Auditory System.
Y. Gutfreund, W. Zheng, and E. I. Knudsen (2002)
Science 297, 1556-1559
   Abstract »    Full Text »    PDF »
Operant Reward Learning in Aplysia: Neuronal Correlates and Mechanisms.
B. Brembs, F. D. Lorenzetti, F. D. Reyes, D. A. Baxter, and J. H. Byrne (2002)
Science 296, 1706-1709
   Abstract »    Full Text »    PDF »
Central regulation of cerebellar climbing fibre input during motor learning.
R. Apps and S. Lee (2002)
J. Physiol. 541, 301-317
   Abstract »    Full Text »    PDF »
Mapping Pavlovian Conditioning Effects on the Brain: Blocking, Contiguity, and Excitatory Effects.
D. Jones and F. Gonzalez-Lima (2001)
J Neurophysiol 86, 809-823
   Abstract »    Full Text »    PDF »
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles.
M. Ito (2001)
Physiol Rev 81, 1143-1195
   Abstract »    Full Text »    PDF »
Changes in the Responses of Purkinje Cells in the Floccular Complex of Monkeys After Motor Learning in Smooth Pursuit Eye Movements.
M. Kahlon and S. G. Lisberger (2000)
J Neurophysiol 84, 2945-2960
   Abstract »    Full Text »    PDF »
Effects of Nucleus Prepositus Hypoglossi Lesions on Visual Climbing Fiber Activity in the Rabbit Flocculus.
M. P. Arts, C. I. De Zeeuw, J. Lips, E. Rosbak, and J. I. Simpson (2000)
J Neurophysiol 84, 2552-2563
   Abstract »    Full Text »    PDF »
Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Inferior Olive.
D. A. Nicholson and J. H. Freeman Jr (2000)
J. Neurosci. 20, 8218-8226
   Abstract »    Full Text »    PDF »
Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation.
J. F. Medina, K. S. Garcia, W. L. Nores, N. M. Taylor, and M. D. Mauk (2000)
J. Neurosci. 20, 5516-5525
   Abstract »    Full Text »    PDF »
The Operant and the Classical in Conditioned Orientation of Drosophila melanogaster at the Flight Simulator.
B. Brembs and M. Heisenberg (2000)
Learn. Mem. 7, 104-115
   Abstract »    Full Text »
No evidence for olfactory blocking in honeybee classical conditioning.
B Gerber and J Ullrich (1999)
J. Exp. Biol. 202, 1839-1854
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)