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Science 23 January 1998:
Vol. 279. no. 5350, pp. 527 - 533
DOI: 10.1126/science.279.5350.527
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Articles

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

Valerie Mermall, Penny L. Post, Mark S. Mooseker *

In the past few years genetic, biochemical, and cytolocalization data have implicated members of the myosin superfamily of actin-based molecular motors in a variety of cellular functions including membrane trafficking, cell movements, and signal transduction. The importance of myosins is illustrated by the identification of myosin genes as targets for disease-causing mutations. The task at hand is to decipher how the multitude of myosins function at both the molecular and cellular level--a task facilitated by our understanding of myosin structure and function in muscle.

The authors are in the Departments of Biology, Cell Biology, and Pathology, Yale University 342 KBT, New Haven, CT 06520, USA.
*   To whom correspondence should be addressed. E-mail: mark.mooseker{at}yale.edu

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J. Cell Sci. 114, 69-79
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The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a.
J. M. Jones, J.-D. Huang, V. Mermall, B. A. Hamilton, M. S. Mooseker, A. Escayg, N. G. Copeland, N. A. Jenkins, and M. H. Meisler (2000)
Hum. Mol. Genet. 9, 821-828
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Effect of ADP and Ionic Strength on the Kinetic and Motile Properties of Recombinant Mouse Myosin V.
F. Wang, L. Chen, O. Arcucci, E. V. Harvey, B. Bowers, Y. Xu, J. A. Hammer III, and J. R. Sellers (2000)
J. Biol. Chem. 275, 4329-4335
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Rab7: A Key to Lysosome Biogenesis.
C. Bucci, P. Thomsen, P. Nicoziani, J. McCarthy, and B. van Deurs (2000)
Mol. Biol. Cell 11, 467-480
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A Role for Myosin-I in Actin Assembly through Interactions with Vrp1p, Bee1p, and the Arp2/3 Complex.
M. Evangelista, B. M. Klebl, A. H.Y. Tong, B. A. Webb, T. Leeuw, E. Leberer, M. Whiteway, D. Y. Thomas, and C. Boone (2000)
J. Cell Biol. 148, 353-362
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Myosin light chain kinase plays an essential role in S. flexneri dissemination.
M Rathman, P de Lanerolle, H Ohayon, P Gounon, and P Sansonetti (2000)
J. Cell Sci. 113, 3375-3386
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Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.
J. Berg, B. Derfler, C. Pennisi, D. Corey, and R. Cheney (2000)
J. Cell Sci. 113, 3439-3451
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Talin controls the exit of the integrin alpha 5 beta 1 from an early compartment of the secretory pathway.
V Martel, L Vignoud, S Dupe, P Frachet, M. Block, and C Albiges-Rizo (2000)
J. Cell Sci. 113, 1951-1961
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Dictyostelium myosin IK is involved in the maintenance of cortical tension and affects motility and phagocytosis.
E. Schwarz, E. Neuhaus, C Kistler, A. Henkel, and T Soldati (2000)
J. Cell Sci. 113, 621-633
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The cytoskeleton of digestive epithelia in health and disease.
N.-O. Ku, X. Zhou, D. M. Toivola, and M. B. Omary (1999)
Am J Physiol Gastrointest Liver Physiol 277, G1108-G1137
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