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Science 23 January 1998:
Vol. 279. no. 5350, pp. 519 - 526
DOI: 10.1126/science.279.5350.519
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Articles

Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

Nobutaka Hirokawa

Cells transport and sort proteins and lipids, after their synthesis, to various destinations at appropriate velocities in membranous organelles and protein complexes. Intracellular transport is thus fundamental to cellular morphogenesis and functioning. Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.

The author is in the Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Tokyo, Japan. E-mail: hirokawa{at}m.u-tokyo.ac.jp

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{beta}-Dystrobrevin interacts directly with kinesin heavy chain in brain.
P. Macioce, G. Gambara, M. Bernassola, L. Gaddini, P. Torreri, G. Macchia, C. Ramoni, M. Ceccarini, and T. C. Petrucci (2003)
J. Cell Sci. 116, 4847-4856
   Abstract »    Full Text »    PDF »
Synaptophysin I Controls the Targeting of VAMP2/Synaptobrevin II to Synaptic Vesicles.
M. Pennuto, D. Bonanomi, F. Benfenati, and F. Valtorta (2003)
Mol. Biol. Cell 14, 4909-4919
   Abstract »    Full Text »    PDF »
Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice.
J. L. Hallows, K. Chen, R. A. DePinho, and I. Vincent (2003)
J. Neurosci. 23, 10633-10644
   Abstract »    Full Text »    PDF »
Cytoplasmic dynein in fungi: insights from nuclear migration.
A. Yamamoto and Y. Hiraoka (2003)
J. Cell Sci. 116, 4501-4512
   Abstract »    Full Text »    PDF »
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
G. Lalli, S. Gschmeissner, and G. Schiavo (2003)
J. Cell Sci. 116, 4639-4650
   Abstract »    Full Text »    PDF »
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line.
G. Goshima and R. D. Vale (2003)
J. Cell Biol. 162, 1003-1016
   Abstract »    Full Text »    PDF »
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head.
T. Nakata and N. Hirokawa (2003)
J. Cell Biol. 162, 1045-1055
   Abstract »    Full Text »    PDF »
Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent process.
S. S. Grieshaber, N. A. Grieshaber, and T. Hackstadt (2003)
J. Cell Sci. 116, 3793-3802
   Abstract »    Full Text »    PDF »
The Kinesin-associated Protein UNC-76 Is Required for Axonal Transport in the Drosophila Nervous System.
J. G. Gindhart, J. Chen, M. Faulkner, R. Gandhi, K. Doerner, T. Wisniewski, and A. Nandlestadt (2003)
Mol. Biol. Cell 14, 3356-3365
   Abstract »    Full Text »    PDF »
From Lysosomes to the Plasma Membrane: LOCALIZATION OF VACUOLAR TYPE H+-ATPase WITH THE a3 ISOFORM DURING OSTEOCLAST DIFFERENTIATION.
T. Toyomura, Y. Murata, A. Yamamoto, T. Oka, G.-H. Sun-Wada, Y. Wada, and M. Futai (2003)
J. Biol. Chem. 278, 22023-22030
   Abstract »    Full Text »    PDF »


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