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Science 23 January 1998:
Vol. 279. no. 5350, pp. 519 - 526
DOI: 10.1126/science.279.5350.519
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Articles

Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

Nobutaka Hirokawa

Cells transport and sort proteins and lipids, after their synthesis, to various destinations at appropriate velocities in membranous organelles and protein complexes. Intracellular transport is thus fundamental to cellular morphogenesis and functioning. Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.

The author is in the Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Tokyo, Japan. E-mail: hirokawa{at}m.u-tokyo.ac.jp

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Cytoplasmic dynein in fungi: insights from nuclear migration.
A. Yamamoto and Y. Hiraoka (2003)
J. Cell Sci. 116, 4501-4512
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Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
G. Lalli, S. Gschmeissner, and G. Schiavo (2003)
J. Cell Sci. 116, 4639-4650
   Abstract »    Full Text »    PDF »
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line.
G. Goshima and R. D. Vale (2003)
J. Cell Biol. 162, 1003-1016
   Abstract »    Full Text »    PDF »
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head.
T. Nakata and N. Hirokawa (2003)
J. Cell Biol. 162, 1045-1055
   Abstract »    Full Text »    PDF »
Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent process.
S. S. Grieshaber, N. A. Grieshaber, and T. Hackstadt (2003)
J. Cell Sci. 116, 3793-3802
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The Kinesin-associated Protein UNC-76 Is Required for Axonal Transport in the Drosophila Nervous System.
J. G. Gindhart, J. Chen, M. Faulkner, R. Gandhi, K. Doerner, T. Wisniewski, and A. Nandlestadt (2003)
Mol. Biol. Cell 14, 3356-3365
   Abstract »    Full Text »    PDF »
From Lysosomes to the Plasma Membrane: LOCALIZATION OF VACUOLAR TYPE H+-ATPase WITH THE a3 ISOFORM DURING OSTEOCLAST DIFFERENTIATION.
T. Toyomura, Y. Murata, A. Yamamoto, T. Oka, G.-H. Sun-Wada, Y. Wada, and M. Futai (2003)
J. Biol. Chem. 278, 22023-22030
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Doublecortin Functions at the Extremities of Growing Neuronal Processes.
G. Friocourt, A. Koulakoff, P. Chafey, D. Boucher, F. Fauchereau, J. Chelly, and F. Francis (2003)
Cereb Cortex 13, 620-626
   Abstract »    Full Text »    PDF »
Kinesin Superfamily Proteins (KIFs) in the Mouse Transcriptome.
H. Miki, M. Setou, RIKEN GER Group, GSL Members, and N. Hirokawa (2003)
Genome Res. 13, 1455-1465
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Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells.
Y. Wang, G. Jerdeva, F. A. Yarber, S. R. da Costa, J. Xie, L. Qian, C. M. Rose, C. Mazurek, N. Kasahara, A. K. Mircheff, et al. (2003)
J. Cell Sci. 116, 2051-2065
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Neural cell adhesion molecule (NCAM) association with PKC{beta}2 via {beta}I spectrin is implicated in NCAM-mediated neurite outgrowth.
I. Leshchyns'ka, V. Sytnyk, J. S. Morrow, and M. Schachner (2003)
J. Cell Biol. 161, 625-639
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